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Dev Biol January 1, 2017; 426 (2): 165-175.

Genome-wide identification of Wnt/β-catenin transcriptional targets during Xenopus gastrulation.

Kjolby RAS , Harland RM .

The canonical Wnt/β-catenin signaling pathway plays multiple roles during Xenopus gastrulation, including posteriorization of the neural plate, patterning of the mesoderm, and induction of the neural crest. Wnt signaling stabilizes β-catenin, which then activates target genes. However, few targets of this signaling pathway that mediate early developmental processes are known. Here we sought to identify transcriptional targets of the Wnt/β-catenin signaling pathway using a genome-wide approach. We selected putative targets using the criteria of reduced expression upon zygotic Wnt knockdown, β-catenin binding within 50kb of the gene, and expression in tissues that receive Wnt signaling. Using these criteria, we found 21 novel direct transcriptional targets of Wnt/β-catenin signaling during gastrulation and in addition have identified putative regulatory elements for further characterization in future studies.

PubMed ID: 27091726
Article link: Dev Biol
Grant support: R01 GM042341 NIGMS NIH HHS , R01 GM086321 NIGMS NIH HHS , R01 HD065705 NICHD NIH HHS

Genes referenced: cdx1 ctnnb1 dkk1 gnao1 irx3 neurog2 pnhd wnt1 wnt8a

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