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Elife. March 28, 2016; 5

Ciliary transcription factors and miRNAs precisely regulate Cp110 levels required for ciliary adhesions and ciliogenesis.

Walentek P , Quigley IK , Sun DI , Sajjan UK , Kintner C , Harland RM .

Upon cell cycle exit, centriole-to-basal body transition facilitates cilia formation. The centriolar protein Cp110 is a regulator of this process and cilia inhibitor, but its positive roles in ciliogenesis remain poorly understood. Using Xenopus we show that Cp110 inhibits cilia formation at high levels, while optimal levels promote ciliogenesis. Cp110 localizes to cilia-forming basal bodies and rootlets, and is required for ciliary adhesion complexes that facilitate Actin interactions. The opposing roles of Cp110 in ciliation are generated in part by coiled-coil domains that mediate preferential binding to centrioles over rootlets. Because of its dual role in ciliogenesis, Cp110 levels must be precisely controlled. In multiciliated cells, this is achieved by both transcriptional and post-transcriptional regulation through ciliary transcription factors and microRNAs, which activate and repress cp110 to produce optimal Cp110 levels during ciliogenesis. Our data provide novel insights into how Cp110 and its regulation contribute to development and cell function.

PubMed ID: 27623009
PMC ID: PMC5045295
Article link: Elife.
Grant support: K99 HL127275 NHLBI NIH HHS , R01 GM042341 NIGMS NIH HHS , R01 GM076507 NIGMS NIH HHS , S10 OD018136 NIH HHS , P30 DK072517 NIDDK NIH HHS , P30 CA014195 NCI NIH HHS

Genes referenced: ccp110 cfp foxj1.2 gnl3 herpud1 nkx2-2 pax6 pitx2 pxn tub

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Antoniades, 2014, Pubmed [+]

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