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Regeneration (Oxf) August 1, 2016; 3 (4): 198-208.

The cellular and molecular mechanisms of tissue repair and regeneration as revealed by studies in Xenopus.

Survival of any living organism critically depends on its ability to repair and regenerate damaged tissues and/or organs during its lifetime following injury, disease, or aging. Various animal models from invertebrates to vertebrates have been used to investigate the molecular and cellular mechanisms of wound healing and tissue regeneration. It is hoped that such studies will form the framework for identifying novel clinical treatments that will improve the healing and regenerative capacity of humans. Amongst these models, Xenopus stands out as a particularly versatile and powerful system. This review summarizes recent findings using this model, which have provided fundamental knowledge of the mechanisms responsible for efficient and perfect tissue repair and regeneration.

PubMed ID: 27800170
PMC ID: PMC5084359
Article link: Regeneration (Oxf)
Grant support: [+]
Genes referenced: abr akt1 cdc42 rac1 rho rho.2 rhoa

Article Images: [+] show captions
References [+] :
Amaya, Xenomics. 2005, Pubmed, Xenbase

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