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XB-ART-52791
Biol Open November 15, 2016; 5 (11): 1631-1641.

MarvelD3 regulates the c-Jun N-terminal kinase pathway during eye development in Xenopus.

Vacca B , Sanchez-Heras E , Steed E , Balda MS , Ohnuma SI , Sasai N , Mayor R , Matter K .


Abstract
Ocular morphogenesis requires several signalling pathways controlling the expression of transcription factors and cell-cycle regulators. However, despite a well-known mechanism, the dialogue between those signals and factors remains to be unveiled. Here, we identify a requirement for MarvelD3, a tight junction transmembrane protein, in eye morphogenesis in Xenopus MarvelD3 depletion led to an abnormally pigmented eye or even an eye-less phenotype, which was rescued by ectopic MarvelD3 expression. Altering MarvelD3 expression led to deregulated expression of cell-cycle regulators and transcription factors required for eye development. The eye phenotype was rescued by increased c-Jun terminal Kinase activation. Thus, MarvelD3 links tight junctions and modulation of the JNK pathway to eye morphogenesis.

PubMed ID: 27870636
PMC ID: PMC5155527
Article link: Biol Open

Genes referenced: ccnd1 gnl3 jun marveld3 mmut otx2 pax6 rax rho
GO keywords: eye development
Morpholinos: marveld3 MO1 marveld3 MO2


Article Images: [+] show captions
References:
Auger, 2012, Pubmed, Xenbase [+]


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