XB-ART-52838
Dev Biol
January 15, 2017;
421
(2):
171-182.
Pa2G4 is a novel Six1 co-factor that is required for neural crest and otic development.
Abstract
Mutations in SIX1 and in its co-factor, EYA1, underlie Branchiootorenal Spectrum disorder (BOS), which is characterized by variable branchial arch, otic and kidney malformations. However, mutations in these two genes are identified in only half of patients. We screened for other potential co-factors, and herein characterize one of them, Pa2G4 (aka Ebp1/Plfap). In human embryonic kidney cells, Pa2G4 binds to Six1 and interferes with the Six1-Eya1 complex. In Xenopus embryos, knock-down of Pa2G4 leads to down-regulation of neural border zone, neural crest and cranial placode genes, and concomitant expansion of neural plate genes. Gain-of-function leads to a broader neural border zone, expanded neural crest and altered cranial placode domains. In loss-of-function assays, the later developing otocyst is reduced in size, which impacts gene expression. In contrast, the size of the otocyst in gain-of-function assays is not changed but the expression domains of several otocyst genes are reduced. Together these findings establish an interaction between Pa2G4 and Six1, and demonstrate that it has an important role in the development of tissues affected in BOS. Thereby, we suggest that pa2g4 is a potential candidate gene for BOS.
PubMed ID: 27940157
PMC ID: PMC5221411
Article link: Dev Biol
Grant support: [+]
R01 DE016289 NIDCR NIH HHS, R01 DE022065 NIDCR NIH HHS, R03 HD055321 NICHD NIH HHS , U54 HD090257 NICHD NIH HHS
Species referenced: Xenopus laevis
Genes referenced: ctrl dlx5 eya1 foxd3 foxd4l1.1 irx1 msx1 myc otx2 pa2g4 pax2 pax3 six1 sox11 sox2 sox9 tbx1 tfap2a zic2
GO keywords: neural crest cell development [+]
Morpholinos: pa2g4 MO3 pa2g4 MO4
Disease Ontology terms: branchiootorenal syndrome
OMIMs: BRANCHIOOTORENAL SYNDROME 1; BOR1 [+]
Article Images: [+] show captions
References [+] :
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The Drosophila Wilms׳ Tumor 1-Associating Protein (WTAP) homolog is required for eye development.
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The Drosophila Wilms׳ Tumor 1-Associating Protein (WTAP) homolog is required for eye development.
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Blanco, Genetic interactions of eyes absent, twin of eyeless and orthodenticle regulate sine oculis expression during ocellar development in Drosophila. 2010, Pubmed
Bricaud, Balancing cell numbers during organogenesis: Six1a differentially affects neurons and sensory hair cells in the inner ear. 2011, Pubmed
Bricaud, The transcription factor six1 inhibits neuronal and promotes hair cell fate in the developing zebrafish (Danio rerio) inner ear. 2006, Pubmed
Brugmann, Six1 promotes a placodal fate within the lateral neurogenic ectoderm by functioning as both a transcriptional activator and repressor. 2004, Pubmed , Xenbase
Brugmann, Induction and specification of the vertebrate ectodermal placodes: precursors of the cranial sensory organs. 2005, Pubmed , Xenbase
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Chai, Transcriptional activation of the SALL1 by the human SIX1 homeodomain during kidney development. 2006, Pubmed
Chen, Initiation of olfactory placode development and neurogenesis is blocked in mice lacking both Six1 and Six4. 2009, Pubmed
Cheyette, The Drosophila sine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system. 1994, Pubmed
Christophorou, Activation of Six1 target genes is required for sensory placode formation. 2009, Pubmed
Cox, The genetics of auricular development and malformation: new findings in model systems driving future directions for microtia research. 2014, Pubmed
Elepfandt, Hearing threshold and frequency discrimination in the purely aquatic frog Xenopus laevis (Pipidae): measurement by means of conditioning. 2001, Pubmed , Xenbase
Fekete, Developmental biology. A transition in the middle ear. 2013, Pubmed
Figeac, ErbB3 binding protein-1 (Ebp1) controls proliferation and myogenic differentiation of muscle stem cells. 2014, Pubmed
Gaur, Neural transcription factors bias cleavage stage blastomeres to give rise to neural ectoderm. 2016, Pubmed , Xenbase
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Glavic, Role of BMP signaling and the homeoprotein Iroquois in the specification of the cranial placodal field. 2004, Pubmed , Xenbase
Gray, Mouse brain organization revealed through direct genome-scale TF expression analysis. 2004, Pubmed
Grifone, Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo. 2005, Pubmed
Groves, Setting appropriate boundaries: fate, patterning and competence at the neural plate border. 2014, Pubmed , Xenbase
Hayashi, Cell-type-specific transcription of prospero is controlled by combinatorial signaling in the Drosophila eye. 2008, Pubmed
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Hilgert, Function and expression pattern of nonsyndromic deafness genes. 2009, Pubmed
Ikeda, Six1 is essential for early neurogenesis in the development of olfactory epithelium. 2007, Pubmed
Ikeda, Six1 is indispensable for production of functional progenitor cells during olfactory epithelial development. 2011, Pubmed
Karpinka, Xenbase, the Xenopus model organism database; new virtualized system, data types and genomes. 2015, Pubmed , Xenbase
Kawakami, Six family genes--structure and function as transcription factors and their roles in development. 2000, Pubmed
Kenyon, Fly SIX-type homeodomain proteins Sine oculis and Optix partner with different cofactors during eye development. 2005, Pubmed
Kim, Negative regulation of p53 by the long isoform of ErbB3 binding protein Ebp1 in brain tumors. 2010, Pubmed
Ko, Opposing roles of the two isoforms of ErbB3 binding protein 1 in human cancer cells. 2016, Pubmed
Kobayashi, The homeobox protein Six3 interacts with the Groucho corepressor and acts as a transcriptional repressor in eye and forebrain formation. 2001, Pubmed
Konishi, Six1 and Six4 promote survival of sensory neurons during early trigeminal gangliogenesis. 2006, Pubmed
Kowalinski, The crystal structure of Ebp1 reveals a methionine aminopeptidase fold as binding platform for multiple interactions. 2007, Pubmed
Laclef, Thymus, kidney and craniofacial abnormalities in Six 1 deficient mice. 2003, Pubmed
Lee, Sox9 function in craniofacial development and disease. 2011, Pubmed , Xenbase
Li, EYA1 mutations associated with the branchio-oto-renal syndrome result in defective otic development in Xenopus laevis. 2010, Pubmed , Xenbase
Liu, Ebp1 isoforms distinctively regulate cell survival and differentiation. 2006, Pubmed
Lu, The ErbB3 binding protein EBP1 regulates ErbB2 protein levels and tamoxifen sensitivity in breast cancer cells. 2011, Pubmed
Mason, STRUCTURE AND FUNCTION OF THE MIDDLE EAR APPARATUS OF THE AQUATIC FROG, XENOPUS LAEVIS. 2011, Pubmed , Xenbase
Monie, Structural insights into the transcriptional and translational roles of Ebp1. 2007, Pubmed
Moody, Segregation of fate during cleavage of frog (Xenopus laevis) blastomeres. 1991, Pubmed , Xenbase
Moody, Transcriptional regulation of cranial sensory placode development. 2015, Pubmed
Moody, Fates of the blastomeres of the 16-cell stage Xenopus embryo. 1987, Pubmed , Xenbase
Moody, Using Xenopus to discover new genes involved in branchiootorenal spectrum disorders. 2015, Pubmed , Xenbase
Neely, A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. 2010, Pubmed
Neilson, Developmental expression patterns of candidate cofactors for vertebrate six family transcription factors. 2010, Pubmed , Xenbase
Neilson, Specific domains of FoxD4/5 activate and repress neural transcription factor genes to control the progression of immature neural ectoderm to differentiating neural plate. 2012, Pubmed , Xenbase
Ohto, Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya. 2000, Pubmed
Ozaki, Impaired interactions between mouse Eyal harboring mutations found in patients with branchio-oto-renal syndrome and Six, Dach, and G proteins. 2002, Pubmed
Ozaki, Six1 controls patterning of the mouse otic vesicle. 2004, Pubmed
Pandur, Xenopus Six1 gene is expressed in neurogenic cranial placodes and maintained in the differentiating lateral lines. 2000, Pubmed , Xenbase
Park, Long-term consequences of Sox9 depletion on inner ear development. 2010, Pubmed , Xenbase
Patrick, Biochemical and functional characterization of six SIX1 Branchio-oto-renal syndrome mutations. 2009, Pubmed
Patrick, Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome. 2013, Pubmed
Pauli, Identification of functional sine oculis motifs in the autoregulatory element of its own gene, in the eyeless enhancer and in the signalling gene hedgehog. 2005, Pubmed
Pearl, Development of Xenopus resource centers: the National Xenopus Resource and the European Xenopus Resource Center. 2012, Pubmed , Xenbase
Pignoni, The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye development. 1998, Pubmed
Piñeiro, A conserved transcriptional network regulates lamina development in the Drosophila visual system. 2014, Pubmed
Powers, Probing the Xenopus laevis inner ear transcriptome for biological function. 2012, Pubmed , Xenbase
Pudney, Establishment of a cell line (XTC-2) from the South African clawed toad, Xenopus laevis. 1973, Pubmed , Xenbase
Quick, Inner ear formation during the early larval development of Xenopus laevis. 2005, Pubmed , Xenbase
Ruf, SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes. 2004, Pubmed
Saint-Jeannet, Establishing the pre-placodal region and breaking it into placodes with distinct identities. 2014, Pubmed , Xenbase
Sanggaard, Branchio-oto-renal syndrome: detection of EYA1 and SIX1 mutations in five out of six Danish families by combining linkage, MLPA and sequencing analyses. 2007, Pubmed
Schlosser, Eya1 and Six1 promote neurogenesis in the cranial placodes in a SoxB1-dependent fashion. 2008, Pubmed , Xenbase
Schoffelen, Mechanics of the exceptional anuran ear. 2008, Pubmed
Serikaku, sine oculis is a homeobox gene required for Drosophila visual system development. 1995, Pubmed
Silver, Functional dissection of eyes absent reveals new modes of regulation within the retinal determination gene network. 2003, Pubmed
Smith, Xenopus cell lines. 1992, Pubmed , Xenbase
Squatrito, EBP1 is a nucleolar growth-regulating protein that is part of pre-ribosomal ribonucleoprotein complexes. 2004, Pubmed
Thompson, Dual origin of the epithelium of the mammalian middle ear. 2013, Pubmed
Van Dijk, Mechanics of the frog ear. 2011, Pubmed
Vize, Xenopus genomic data and browser resources. 2016, Pubmed , Xenbase
Xia, Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb transcriptional regulation. 2001, Pubmed
Xia, Analysis of the expression pattern of Ebp1, an ErbB-3-binding protein. 2001, Pubmed
Yajima, Six family genes control the proliferation and differentiation of muscle satellite cells. 2010, Pubmed
Yan, A transcriptional chain linking eye specification to terminal determination of cone cells in the Drosophila eye. 2003, Pubmed
Yan, foxD5 plays a critical upstream role in regulating neural ectodermal fate and the onset of neural differentiation. 2009, Pubmed , Xenbase
Yang, Transcriptomes of lineage-specific Drosophila neuroblasts profiled by genetic targeting and robotic sorting. 2016, Pubmed
Yoo, Interaction of the PA2G4 (EBP1) protein with ErbB-3 and regulation of this binding by heregulin. 2000, Pubmed
Zaghloul, Alterations of rx1 and pax6 expression levels at neural plate stages differentially affect the production of retinal cell types and maintenance of retinal stem cell qualities. 2007, Pubmed , Xenbase
Zhang, Direct control of neurogenesis by selector factors in the fly eye: regulation of atonal by Ey and So. 2006, Pubmed
Zhang, The ErbB3 binding protein Ebp1 interacts with Sin3A to repress E2F1 and AR-mediated transcription. 2005, Pubmed
Zhang, The ErbB3-binding protein Ebp1 suppresses androgen receptor-mediated gene transcription and tumorigenesis of prostate cancer cells. 2005, Pubmed
Zhang, Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1. 2002, Pubmed
Zhang, Alterations in cell growth and signaling in ErbB3 binding protein-1 (Ebp1) deficient mice. 2009, Pubmed
Zhang, Heregulin regulates the ability of the ErbB3-binding protein Ebp1 to bind E2F promoter elements and repress E2F-mediated transcription. 2004, Pubmed
Zheng, The role of Six1 in mammalian auditory system development. 2003, Pubmed
Zhou, Post-transcriptional regulation of androgen receptor mRNA by an ErbB3 binding protein 1 in prostate cancer. 2010, Pubmed
Zhou, Onset of atonal expression in Drosophila retinal progenitors involves redundant and synergistic contributions of Ey/Pax6 and So binding sites within two distant enhancers. 2014, Pubmed
Zhu, Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors. 2002, Pubmed
Zou, Eya1 and Six1 are essential for early steps of sensory neurogenesis in mammalian cranial placodes. 2004, Pubmed
Bajoghli, Groucho corepressor proteins regulate otic vesicle outgrowth. 2005, Pubmed
Bane, EYA1 expression in the developing inner ear. 2005, Pubmed , Xenbase
Bidet, Modifiers of muscle and heart cell fate specification identified by gain-of-function screen in Drosophila. 2003, Pubmed
Blanco, Genetic interactions of eyes absent, twin of eyeless and orthodenticle regulate sine oculis expression during ocellar development in Drosophila. 2010, Pubmed
Bricaud, Balancing cell numbers during organogenesis: Six1a differentially affects neurons and sensory hair cells in the inner ear. 2011, Pubmed
Bricaud, The transcription factor six1 inhibits neuronal and promotes hair cell fate in the developing zebrafish (Danio rerio) inner ear. 2006, Pubmed
Brugmann, Six1 promotes a placodal fate within the lateral neurogenic ectoderm by functioning as both a transcriptional activator and repressor. 2004, Pubmed , Xenbase
Brugmann, Induction and specification of the vertebrate ectodermal placodes: precursors of the cranial sensory organs. 2005, Pubmed , Xenbase
Buitrago-Delgado, NEURODEVELOPMENT. Shared regulatory programs suggest retention of blastula-stage potential in neural crest cells. 2015, Pubmed , Xenbase
Chai, Transcriptional activation of the SALL1 by the human SIX1 homeodomain during kidney development. 2006, Pubmed
Chen, Initiation of olfactory placode development and neurogenesis is blocked in mice lacking both Six1 and Six4. 2009, Pubmed
Cheyette, The Drosophila sine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system. 1994, Pubmed
Christophorou, Activation of Six1 target genes is required for sensory placode formation. 2009, Pubmed
Cox, The genetics of auricular development and malformation: new findings in model systems driving future directions for microtia research. 2014, Pubmed
Elepfandt, Hearing threshold and frequency discrimination in the purely aquatic frog Xenopus laevis (Pipidae): measurement by means of conditioning. 2001, Pubmed , Xenbase
Fekete, Developmental biology. A transition in the middle ear. 2013, Pubmed
Figeac, ErbB3 binding protein-1 (Ebp1) controls proliferation and myogenic differentiation of muscle stem cells. 2014, Pubmed
Gaur, Neural transcription factors bias cleavage stage blastomeres to give rise to neural ectoderm. 2016, Pubmed , Xenbase
Ghanbari, Molecular cloning and embryonic expression of Xenopus Six homeobox genes. 2001, Pubmed , Xenbase
Giot, A protein interaction map of Drosophila melanogaster. 2003, Pubmed
Glavic, Role of BMP signaling and the homeoprotein Iroquois in the specification of the cranial placodal field. 2004, Pubmed , Xenbase
Gray, Mouse brain organization revealed through direct genome-scale TF expression analysis. 2004, Pubmed
Grifone, Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo. 2005, Pubmed
Groves, Setting appropriate boundaries: fate, patterning and competence at the neural plate border. 2014, Pubmed , Xenbase
Hayashi, Cell-type-specific transcription of prospero is controlled by combinatorial signaling in the Drosophila eye. 2008, Pubmed
Hendzel, Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation. 1998, Pubmed
Hilgert, Function and expression pattern of nonsyndromic deafness genes. 2009, Pubmed
Ikeda, Six1 is essential for early neurogenesis in the development of olfactory epithelium. 2007, Pubmed
Ikeda, Six1 is indispensable for production of functional progenitor cells during olfactory epithelial development. 2011, Pubmed
Karpinka, Xenbase, the Xenopus model organism database; new virtualized system, data types and genomes. 2015, Pubmed , Xenbase
Kawakami, Six family genes--structure and function as transcription factors and their roles in development. 2000, Pubmed
Kenyon, Fly SIX-type homeodomain proteins Sine oculis and Optix partner with different cofactors during eye development. 2005, Pubmed
Kim, Negative regulation of p53 by the long isoform of ErbB3 binding protein Ebp1 in brain tumors. 2010, Pubmed
Ko, Opposing roles of the two isoforms of ErbB3 binding protein 1 in human cancer cells. 2016, Pubmed
Kobayashi, The homeobox protein Six3 interacts with the Groucho corepressor and acts as a transcriptional repressor in eye and forebrain formation. 2001, Pubmed
Konishi, Six1 and Six4 promote survival of sensory neurons during early trigeminal gangliogenesis. 2006, Pubmed
Kowalinski, The crystal structure of Ebp1 reveals a methionine aminopeptidase fold as binding platform for multiple interactions. 2007, Pubmed
Laclef, Thymus, kidney and craniofacial abnormalities in Six 1 deficient mice. 2003, Pubmed
Lee, Sox9 function in craniofacial development and disease. 2011, Pubmed , Xenbase
Li, EYA1 mutations associated with the branchio-oto-renal syndrome result in defective otic development in Xenopus laevis. 2010, Pubmed , Xenbase
Liu, Ebp1 isoforms distinctively regulate cell survival and differentiation. 2006, Pubmed
Lu, The ErbB3 binding protein EBP1 regulates ErbB2 protein levels and tamoxifen sensitivity in breast cancer cells. 2011, Pubmed
Mason, STRUCTURE AND FUNCTION OF THE MIDDLE EAR APPARATUS OF THE AQUATIC FROG, XENOPUS LAEVIS. 2011, Pubmed , Xenbase
Monie, Structural insights into the transcriptional and translational roles of Ebp1. 2007, Pubmed
Moody, Segregation of fate during cleavage of frog (Xenopus laevis) blastomeres. 1991, Pubmed , Xenbase
Moody, Transcriptional regulation of cranial sensory placode development. 2015, Pubmed
Moody, Fates of the blastomeres of the 16-cell stage Xenopus embryo. 1987, Pubmed , Xenbase
Moody, Using Xenopus to discover new genes involved in branchiootorenal spectrum disorders. 2015, Pubmed , Xenbase
Neely, A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. 2010, Pubmed
Neilson, Developmental expression patterns of candidate cofactors for vertebrate six family transcription factors. 2010, Pubmed , Xenbase
Neilson, Specific domains of FoxD4/5 activate and repress neural transcription factor genes to control the progression of immature neural ectoderm to differentiating neural plate. 2012, Pubmed , Xenbase
Ohto, Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya. 2000, Pubmed
Ozaki, Impaired interactions between mouse Eyal harboring mutations found in patients with branchio-oto-renal syndrome and Six, Dach, and G proteins. 2002, Pubmed
Ozaki, Six1 controls patterning of the mouse otic vesicle. 2004, Pubmed
Pandur, Xenopus Six1 gene is expressed in neurogenic cranial placodes and maintained in the differentiating lateral lines. 2000, Pubmed , Xenbase
Park, Long-term consequences of Sox9 depletion on inner ear development. 2010, Pubmed , Xenbase
Patrick, Biochemical and functional characterization of six SIX1 Branchio-oto-renal syndrome mutations. 2009, Pubmed
Patrick, Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome. 2013, Pubmed
Pauli, Identification of functional sine oculis motifs in the autoregulatory element of its own gene, in the eyeless enhancer and in the signalling gene hedgehog. 2005, Pubmed
Pearl, Development of Xenopus resource centers: the National Xenopus Resource and the European Xenopus Resource Center. 2012, Pubmed , Xenbase
Pignoni, The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye development. 1998, Pubmed
Piñeiro, A conserved transcriptional network regulates lamina development in the Drosophila visual system. 2014, Pubmed
Powers, Probing the Xenopus laevis inner ear transcriptome for biological function. 2012, Pubmed , Xenbase
Pudney, Establishment of a cell line (XTC-2) from the South African clawed toad, Xenopus laevis. 1973, Pubmed , Xenbase
Quick, Inner ear formation during the early larval development of Xenopus laevis. 2005, Pubmed , Xenbase
Ruf, SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes. 2004, Pubmed
Saint-Jeannet, Establishing the pre-placodal region and breaking it into placodes with distinct identities. 2014, Pubmed , Xenbase
Sanggaard, Branchio-oto-renal syndrome: detection of EYA1 and SIX1 mutations in five out of six Danish families by combining linkage, MLPA and sequencing analyses. 2007, Pubmed
Schlosser, Eya1 and Six1 promote neurogenesis in the cranial placodes in a SoxB1-dependent fashion. 2008, Pubmed , Xenbase
Schoffelen, Mechanics of the exceptional anuran ear. 2008, Pubmed
Serikaku, sine oculis is a homeobox gene required for Drosophila visual system development. 1995, Pubmed
Silver, Functional dissection of eyes absent reveals new modes of regulation within the retinal determination gene network. 2003, Pubmed
Smith, Xenopus cell lines. 1992, Pubmed , Xenbase
Squatrito, EBP1 is a nucleolar growth-regulating protein that is part of pre-ribosomal ribonucleoprotein complexes. 2004, Pubmed
Thompson, Dual origin of the epithelium of the mammalian middle ear. 2013, Pubmed
Van Dijk, Mechanics of the frog ear. 2011, Pubmed
Vize, Xenopus genomic data and browser resources. 2016, Pubmed , Xenbase
Xia, Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb transcriptional regulation. 2001, Pubmed
Xia, Analysis of the expression pattern of Ebp1, an ErbB-3-binding protein. 2001, Pubmed
Yajima, Six family genes control the proliferation and differentiation of muscle satellite cells. 2010, Pubmed
Yan, A transcriptional chain linking eye specification to terminal determination of cone cells in the Drosophila eye. 2003, Pubmed
Yan, foxD5 plays a critical upstream role in regulating neural ectodermal fate and the onset of neural differentiation. 2009, Pubmed , Xenbase
Yang, Transcriptomes of lineage-specific Drosophila neuroblasts profiled by genetic targeting and robotic sorting. 2016, Pubmed
Yoo, Interaction of the PA2G4 (EBP1) protein with ErbB-3 and regulation of this binding by heregulin. 2000, Pubmed
Zaghloul, Alterations of rx1 and pax6 expression levels at neural plate stages differentially affect the production of retinal cell types and maintenance of retinal stem cell qualities. 2007, Pubmed , Xenbase
Zhang, Direct control of neurogenesis by selector factors in the fly eye: regulation of atonal by Ey and So. 2006, Pubmed
Zhang, The ErbB3 binding protein Ebp1 interacts with Sin3A to repress E2F1 and AR-mediated transcription. 2005, Pubmed
Zhang, The ErbB3-binding protein Ebp1 suppresses androgen receptor-mediated gene transcription and tumorigenesis of prostate cancer cells. 2005, Pubmed
Zhang, Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1. 2002, Pubmed
Zhang, Alterations in cell growth and signaling in ErbB3 binding protein-1 (Ebp1) deficient mice. 2009, Pubmed
Zhang, Heregulin regulates the ability of the ErbB3-binding protein Ebp1 to bind E2F promoter elements and repress E2F-mediated transcription. 2004, Pubmed
Zheng, The role of Six1 in mammalian auditory system development. 2003, Pubmed
Zhou, Post-transcriptional regulation of androgen receptor mRNA by an ErbB3 binding protein 1 in prostate cancer. 2010, Pubmed
Zhou, Onset of atonal expression in Drosophila retinal progenitors involves redundant and synergistic contributions of Ey/Pax6 and So binding sites within two distant enhancers. 2014, Pubmed
Zhu, Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors. 2002, Pubmed
Zou, Eya1 and Six1 are essential for early steps of sensory neurogenesis in mammalian cranial placodes. 2004, Pubmed