XB-ART-52906Sci Rep. September 28, 2016; 6 20974.
Quantifying the cooperative subunit action in a multimeric membrane receptor.
In multimeric membrane receptors the cooperative action of the subunits prevents exact knowledge about the operation and the interaction of the individual subunits. We propose a method that permits quantification of ligand binding to and activation effects of the individual binding sites in a multimeric membrane receptor. The power of this method is demonstrated by gaining detailed insight into the subunit action in olfactory cyclic nucleotide-gated CNGA2 ion channels.
PubMed ID: 26858151
Article link: Sci Rep.
Genes referenced: cnga2