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Sci Rep. September 28, 2016; 6 20974.

Quantifying the cooperative subunit action in a multimeric membrane receptor.

Wongsamitkul N , Nache V , Eick T , Hummert S , Schulz E , Schmauder R , Schirmeyer J , Zimmer T , Benndorf K .

In multimeric membrane receptors the cooperative action of the subunits prevents exact knowledge about the operation and the interaction of the individual subunits. We propose a method that permits quantification of ligand binding to and activation effects of the individual binding sites in a multimeric membrane receptor. The power of this method is demonstrated by gaining detailed insight into the subunit action in olfactory cyclic nucleotide-gated CNGA2 ion channels.

PubMed ID: 26858151
PMC ID: PMC4746656
Article link: Sci Rep.

Genes referenced: cnga2

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