XB-ART-52912Curr Top Dev Biol January 1, 2017; 122 93-115.
Eomesodermin-At Dawn of Cell Fate Decisions During Early Embryogenesis.
Proteins of the large family of T-box transcription factors are implicated in a broad spectrum of developmental processes. Loss-of-function mutations of T-box(Tbx) factors frequently cause severe embryonic phenotypes, often resulting from defects in cell fate specification and lineage differentiation. This review summarizes current knowledge on the functions of the T-box transcription factor Eomesodermin (Eomes) from postfertilization development until gastrulation stages of vertebrate embryos. Eomes exhibits evolutionary conserved functions in cell lineage specification and morphogenesis during gastrulation in all studied vertebrate model systems. In addition, during mammalian embryogenesis, Eomes is crucially required in extraembryonic tissues that are specific for intrauterine development. This chapter mainly focuses on mammalian development of mouse; however, common functions shared among other vertebrate model system, such as embryos of zebrafish and Xenopus laevis, will be compared in the context of specification cell lineages during gastrulation. Furthermore, this review recapitulates the current understanding of the molecular functions and transcriptional targets of Eomes as component of transcriptional complexes that guide cell-type specification and morphogenesis of early vertebrate embryos.
PubMed ID: 28057273
Article link: Curr Top Dev Biol
Genes referenced: cdx2 egf elf5 eomes ets2 fgf8 foxa2 foxh1 gata3 gata5 lhx1 mesp2 nodal pou5f3.1 smad2 smad3 smad4.1 smad4.2 snai1 sox2 tbr1 tbx21 tbx3 tbx6 tbxt tead4 tfap2c tgfb1 vegt wnt1 wnt3