Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
J Neurol
2017 Oct 01;264Suppl 1:28-33. doi: 10.1007/s00415-017-8437-8.
Show Gene links
Show Anatomy links
Moving or being moved: that makes a difference.
Straka H
,
Chagnaud BP
.
???displayArticle.abstract???
During head/body movements, gaze stability is ensured by transformation of motion-related sensory signals into respective motor commands. Passively induced motion in all vertebrates including amphibians evokes a robust vestibulo-ocular reflex, suggesting an equally important role of this motor reaction during actively induced motion. However, during self-induced movements including locomotion, motor efference copies offer a convenient additional substrate for counteracting retinal image displacements. During such locomotor activity in Xenopus laevis tadpoles, spinal central pattern generator-derived efference copies elicit spatio-temporally specific eye movements, which are functionally appropriate to offset swimming-related retinal image displacements. In addition, passively induced horizontal semicircular canal signals are suppressed, making intrinsic spino-extraocular motor coupling the dominating mechanism for gaze stabilization during locomotion. The presence of functionally appropriate efference copy-driven eye movements in adult frogs with limb-based locomotion suggests that this mechanism might play a role for gaze stability during rhythmic locomotion also in other vertebrates.
Angelaki,
Vestibular system: the many facets of a multimodal sense.
2008, Pubmed
Angelaki,
Vestibular system: the many facets of a multimodal sense.
2008,
Pubmed
Brandt,
You are better off running than walking with acute vestibulopathy.
1999,
Pubmed
Chagnaud,
Spinal corollary discharge modulates motion sensing during vertebrate locomotion.
2015,
Pubmed
,
Xenbase
Chagnaud,
Predictability of visual perturbation during locomotion: implications for corrective efference copy signaling.
2012,
Pubmed
,
Xenbase
Combes,
An intrinsic feed-forward mechanism for vertebrate gaze stabilization.
2008,
Pubmed
,
Xenbase
Combes,
Developmental segregation of spinal networks driving axial- and hindlimb-based locomotion in metamorphosing Xenopus laevis.
2004,
Pubmed
,
Xenbase
Cullen,
The neural encoding of self-motion.
2011,
Pubmed
Cullen,
Sensory signals during active versus passive movement.
2004,
Pubmed
Cullen,
The vestibular system: multimodal integration and encoding of self-motion for motor control.
2012,
Pubmed
Dietrich,
Functional Organization of Vestibulo-Ocular Responses in Abducens Motoneurons.
2017,
Pubmed
,
Xenbase
Dietrich,
Prolonged vestibular stimulation induces homeostatic plasticity of the vestibulo-ocular reflex in larval Xenopus laevis.
2016,
Pubmed
,
Xenbase
Gensberger,
Galvanic Vestibular Stimulation: Cellular Substrates and Response Patterns of Neurons in the Vestibulo-Ocular Network.
2016,
Pubmed
,
Xenbase
Haddon,
Hyaluronan as a propellant for epithelial movement: the development of semicircular canals in the inner ear of Xenopus.
1991,
Pubmed
,
Xenbase
Lambert,
Semicircular canal size determines the developmental onset of angular vestibuloocular reflexes in larval Xenopus.
2008,
Pubmed
,
Xenbase
Lambert,
Gaze stabilization by efference copy signaling without sensory feedback during vertebrate locomotion.
2012,
Pubmed
,
Xenbase
Medrea,
Multisensory integration in early vestibular processing in mice: the encoding of passive vs. active motion.
2013,
Pubmed
SPERRY,
Neural basis of the spontaneous optokinetic response produced by visual inversion.
1950,
Pubmed
Straka,
Vestibular animal models: contributions to understanding physiology and disease.
2016,
Pubmed
Straka,
Xenopus laevis: an ideal experimental model for studying the developmental dynamics of neural network assembly and sensory-motor computations.
2012,
Pubmed
,
Xenbase
Straka,
Basic organization principles of the VOR: lessons from frogs.
2004,
Pubmed
von Uckermann,
Spinal efference copy signaling and gaze stabilization during locomotion in juvenile Xenopus frogs.
2013,
Pubmed
,
Xenbase
