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Nat Commun September 24, 2015; 6 8388.

PTEN regulates cilia through Dishevelled.

Shnitsar I , Bashkurov M , Masson GR , Ogunjimi AA , Mosessian S , Cabeza EA , Hirsch CL , Trcka D , Gish G , Jiao J , Wu H , Winklbauer R , Williams RL , Pelletier L , Wrana JL , Barrios-Rodiles M .

Cilia are hair-like cellular protrusions important in many aspects of eukaryotic biology. For instance, motile cilia enable fluid movement over epithelial surfaces, while primary (sensory) cilia play roles in cellular signalling. The molecular events underlying cilia dynamics, and particularly their disassembly, are not well understood. Phosphatase and tensin homologue (PTEN) is an extensively studied tumour suppressor, thought to primarily act by antagonizing PI3-kinase signalling. Here we demonstrate that PTEN plays an important role in multicilia formation and cilia disassembly by controlling the phosphorylation of Dishevelled (DVL), another ciliogenesis regulator. DVL is a central component of WNT signalling that plays a role during convergent extension movements, which we show here are also regulated by PTEN. Our studies identify a novel protein substrate for PTEN that couples PTEN to regulation of cilia dynamics and WNT signalling, thus advancing our understanding of potential underlying molecular etiologies of PTEN-related pathologies.

PubMed ID: 26399523
PMC ID: PMC4598566
Article link: Nat Commun
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: dvl1 dvl2 dvl3 pcnt pten tgfbi tns1

Article Images: [+] show captions
References [+] :
Avasthi, Stages of ciliogenesis and regulation of ciliary length. 2012, Pubmed