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XB-ART-53549
Rouxs Arch Dev Biol March 1, 1990; 198 (6): 330-335.

Mesodermal induction in early amphibian embryos by activin A (erythroid differentiation factor).

Asashima M , Nakano H , Shimada K , Kinoshita K , Ishii K , Shibai H , Ueno N .


Abstract
Recently the mesoderm-inducing effects of the transforming growth factor β (TGF-β) family of proteins have been widely examined. In an attemt to elucidate the functions of these proteins, porcine inhibin A and activin A (erythroid differentiation factor; EDF) were examined. Treatment of explants with activin A led to differentiation of mesodermal derivatives such as mesenchyme, notochord, blood cells and muscle, but inhibin A had a much lesser effect. The mesodermal differentiation induced by activin A was also comfirmed by analyses using a polyclonal antibody against muscle myosin. By indirect immunofluorescence analysis, the differentiation of muscle blocks was observed in the activin-A-treated explants, whereas no differentiation was observed in inhibin-A-treated and control explants. These findings confirm that this protein of the TGF-β family has mesoderm-inducing ability.

PubMed ID: 28305412
Article link: Rouxs Arch Dev Biol


Species referenced: Xenopus
Genes referenced: inhbb

References [+] :
Asashima, Inducing effects of the grey crescent region of early developmental stages of ambystoma mexicanum. 2017, Pubmed