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Elife January 1, 2017; 6

Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes.

Hockman D , Burns AJ , Schlosser G , Gates KP , Jevans B , Mongera A , Fisher S , Unlu G , Knapik EW , Kaufman CK , Mosimann C , Zon LI , Lancman JJ , Dong PDS , Lickert H , Tucker AS , Baker CV .

The evolutionary origins of the hypoxia-sensitive cells that trigger amniote respiratory reflexes - carotid body glomus cells, and ''pulmonary neuroendocrine cells'' (PNECs) - are obscure. Homology has been proposed between glomus cells, which are neural crest-derived, and the hypoxia-sensitive ''neuroepithelial cells'' (NECs) of fish gills, whose embryonic origin is unknown. NECs have also been likened to PNECs, which differentiate in situ within lung airway epithelia. Using genetic lineage-tracing and neural crest-deficient mutants in zebrafish, and physical fate-mapping in frog and lamprey, we find that NECs are not neural crest-derived, but endoderm-derived, like PNECs, whose endodermal origin we confirm. We discover neural crest-derived catecholaminergic cells associated with zebrafish pharyngeal arch blood vessels, and propose a new model for amniote hypoxia-sensitive cell evolution: endoderm-derived NECs were retained as PNECs, while the carotid body evolved via the aggregation of neural crest-derived catecholaminergic (chromaffin) cells already associated with blood vessels in anamniote pharyngeal arches.

PubMed ID: 28387645
PMC ID: PMC5438250
Article link: Elife
Grant support: [+]

Species referenced: Xenopus
Genes referenced: ascl1 b3gat1l kcnt1 myh1 npat phox2b slc7a5 wnt1

Article Images: [+] show captions
References [+] :
Abo, A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1). 1981, Pubmed, Xenbase