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Elife. September 25, 2017; 6

Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes.

Hockman D , Burns AJ , Schlosser G , Gates KP , Jevans B , Mongera A , Fisher S , Unlu G , Knapik EW , Kaufman CK , Mosimann C , Zon LI , Lancman JJ , Dong PDS , Lickert H , Tucker AS , Baker CVH .

The evolutionary origins of the hypoxia-sensitive cells that trigger amniote respiratory reflexes - carotid body glomus cells, and ''pulmonary neuroendocrine cells'' (PNECs) - are obscure. Homology has been proposed between glomus cells, which are neural crest-derived, and the hypoxia-sensitive ''neuroepithelial cells'' (NECs) of fish gills, whose embryonic origin is unknown. NECs have also been likened to PNECs, which differentiate in situ within lung airway epithelia. Using genetic lineage-tracing and neural crest-deficient mutants in zebrafish, and physical fate-mapping in frog and lamprey, we find that NECs are not neural crest-derived, but endoderm-derived, like PNECs, whose endodermal origin we confirm. We discover neural crest-derived catecholaminergic cells associated with zebrafish pharyngeal arch blood vessels, and propose a new model for amniote hypoxia-sensitive cell evolution: endoderm-derived NECs were retained as PNECs, while the carotid body evolved via the aggregation of neural crest-derived catecholaminergic (chromaffin) cells already associated with blood vessels in anamniote pharyngeal arches.

PubMed ID: 28387645
Article link: Elife.
Grant support: R01 HL092217 NHLBI NIH HHS , DP2 DK098092 NIDDK NIH HHS , R21 DE021509 NIDCR NIH HHS, R01 DE018477 NIDCR NIH HHS, Wellcome Trust

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