Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Nat Cell Biol
2016 May 27;186:593-4. doi: 10.1038/ncb3367.
Show Gene links
Show Anatomy links
Replicating repetitive DNA.
Tognetti S
,
Speck C
.
???displayArticle.abstract???
The function and regulation of repetitive DNA, the 'dark matter' of the genome, is still only rudimentarily understood. Now a study investigating DNA replication of repetitive centromeric chromosome segments has started to expose a fascinating replication program that involves suppression of ATR signalling, in particular during replication stress.
Aze,
Centromeric DNA replication reconstitution reveals DNA loops and ATR checkpoint suppression.
2016, Pubmed,
Xenbase
Aze,
Centromeric DNA replication reconstitution reveals DNA loops and ATR checkpoint suppression.
2016,
Pubmed
,
Xenbase
Cimprich,
ATR: an essential regulator of genome integrity.
2008,
Pubmed
Forsburg,
The CINs of the centromere.
2013,
Pubmed
Fouché,
Replication fork regression in repetitive DNAs.
2006,
Pubmed
Haye,
The Eukaryotic Mismatch Recognition Complexes Track with the Replisome during DNA Synthesis.
2015,
Pubmed
Hirano,
Condensins: universal organizers of chromosomes with diverse functions.
2012,
Pubmed
,
Xenbase
Masai,
Eukaryotic chromosome DNA replication: where, when, and how?
2010,
Pubmed
Mensenkamp,
Somatic mutations in MLH1 and MSH2 are a frequent cause of mismatch-repair deficiency in Lynch syndrome-like tumors.
2014,
Pubmed
Padeken,
Repeat DNA in genome organization and stability.
2015,
Pubmed
Palm,
How shelterin protects mammalian telomeres.
2008,
Pubmed
Tognetti,
Switch on the engine: how the eukaryotic replicative helicase MCM2-7 becomes activated.
2015,
Pubmed
Toledo,
ATR prohibits replication catastrophe by preventing global exhaustion of RPA.
2013,
Pubmed
Wang,
Condensin promotes the juxtaposition of DNA flanking its loading site in Bacillus subtilis.
2015,
Pubmed