Zinski J , Tajer B , Mullins MC .

R01 GM056326 NIGMS NIH HHS , T32 HD083185 NICHD NIH HHS , F32 HD008318 NICHD NIH HHS

Aamar, Sox17 and chordin are required for formation of Kupffer's vesicle and left-right asymmetry determination in zebrafish. 2010, Pubmed

Aamar, Sox17 and chordin are required for formation of Kupffer's vesicle and left-right asymmetry determination in zebrafish. 2010, Pubmed
Abdollah, TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling. 1997, Pubmed
Abe, Open and closed evolutionary paths for drastic morphological changes, involving serial gene duplication, sub-functionalization, and selection. 2016, Pubmed
Abe, The origin of the bifurcated axial skeletal system in the twin-tail goldfish. 2014, Pubmed
Adachi, Determination of left/right asymmetric expression of nodal by a left side-specific enhancer with sequence similarity to a lefty-2 enhancer. 1999, Pubmed
Adams, Early, H+-V-ATPase-dependent proton flux is necessary for consistent left-right patterning of non-mammalian vertebrates. 2006, Pubmed , Xenbase
Adamska, Wnt and TGF-beta expression in the sponge Amphimedon queenslandica and the origin of metazoan embryonic patterning. 2007, Pubmed
Agathon, The molecular nature of the zebrafish tail organizer. 2003, Pubmed
Agathon, Morpholino knock-down of antivin1 and antivin2 upregulates nodal signaling. 2001, Pubmed
Agius, Endodermal Nodal-related signals and mesoderm induction in Xenopus. 2000, Pubmed , Xenbase
Albano, Expression of inhibin subunits and follistatin during postimplantation mouse development: decidual expression of activin and expression of follistatin in primitive streak, somites and hindbrain. 1994, Pubmed
Albertson, Zebrafish acvr2a and acvr2b exhibit distinct roles in craniofacial development. 2005, Pubmed
Alten, Differential regulation of node formation, nodal ciliogenesis and cilia positioning by Noto and Foxj1. 2012, Pubmed
Amaya, FGF signalling in the early specification of mesoderm in Xenopus. 1993, Pubmed , Xenbase
Amaya, Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos. 1991, Pubmed , Xenbase
Ambrosio, Crossveinless-2 Is a BMP feedback inhibitor that binds Chordin/BMP to regulate Xenopus embryonic patterning. 2008, Pubmed , Xenbase
Andersson, Synergistic interaction between Gdf1 and Nodal during anterior axis development. 2006, Pubmed
Andersson, Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development. 2007, Pubmed , Xenbase
Angerer, A BMP pathway regulates cell fate allocation along the sea urchin animal-vegetal embryonic axis. 2000, Pubmed , Xenbase
Antic, Planar cell polarity enables posterior localization of nodal cilia and left-right axis determination during mouse and Xenopus embryogenesis. 2010, Pubmed , Xenbase
Aoki, Regulation of nodal signalling and mesendoderm formation by TARAM-A, a TGFbeta-related type I receptor. 2002, Pubmed
Armes, The ALK-2 and ALK-4 activin receptors transduce distinct mesoderm-inducing signals during early Xenopus development but do not co-operate to establish thresholds. 1997, Pubmed , Xenbase
Arnold, Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo. 2009, Pubmed
Arnold, Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo. 2006, Pubmed , Xenbase
Aw, The ATP-sensitive K(+)-channel (K(ATP)) controls early left-right patterning in Xenopus and chick embryos. 2010, Pubmed , Xenbase
Aykul, New Ligand Binding Function of Human Cerberus and Role of Proteolytic Processing in Regulating Ligand-Receptor Interactions and Antagonist Activity. 2016, Pubmed
Aykul, Human Cerberus prevents nodal-receptor binding, inhibits nodal signaling, and suppresses nodal-mediated phenotypes. 2015, Pubmed
Bachiller, The role of chordin/Bmp signals in mammalian pharyngeal development and DiGeorge syndrome. 2003, Pubmed
Bachiller, The organizer factors Chordin and Noggin are required for mouse forebrain development. 2000, Pubmed
Bae, Siamois and Twin are redundant and essential in formation of the Spemann organizer. 2011, Pubmed , Xenbase
Baker, Direct and indirect roles for Nodal signaling in two axis conversions during asymmetric morphogenesis of the zebrafish heart. 2008, Pubmed
Bakkers, Zebrafish as a model to study cardiac development and human cardiac disease. 2011, Pubmed
Bakkers, Zebrafish DeltaNp63 is a direct target of Bmp signaling and encodes a transcriptional repressor blocking neural specification in the ventral ectoderm. 2002, Pubmed
Barth, fsi zebrafish show concordant reversal of laterality of viscera, neuroanatomy, and a subset of behavioral responses. 2005, Pubmed
Bassett, Understanding functional miRNA-target interactions in vivo by site-specific genome engineering. 2014, Pubmed
Basu, Cilia multifunctional organelles at the center of vertebrate left-right asymmetry. 2008, Pubmed , Xenbase
Bates, Coco regulates dorsoventral specification of germ layers via inhibition of TGFβ signalling. 2013, Pubmed , Xenbase
Bauer, The type I serine/threonine kinase receptor Alk8/Lost-a-fin is required for Bmp2b/7 signal transduction during dorsoventral patterning of the zebrafish embryo. 2001, Pubmed
Bayramov, Novel functions of Noggin proteins: inhibition of Activin/Nodal and Wnt signaling. 2011, Pubmed , Xenbase
Beck, Extraembryonic proteases regulate Nodal signalling during gastrulation. 2002, Pubmed
Beddington, Axis development and early asymmetry in mammals. 1999, Pubmed
Bell, Cell fate specification and competence by Coco, a maternal BMP, TGFbeta and Wnt inhibitor. 2003, Pubmed , Xenbase
Belo, Generating asymmetries in the early vertebrate embryo: the role of the Cerberus-like family. 2009, Pubmed , Xenbase
Belo, Cerberus-like is a secreted BMP and nodal antagonist not essential for mouse development. 2000, Pubmed , Xenbase
Belting, Pou5f1 contributes to dorsoventral patterning by positive regulation of vox and modulation of fgf8a expression. 2011, Pubmed
Ben-Haim, The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4. 2006, Pubmed
Ben-Zvi, Scaling of the BMP activation gradient in Xenopus embryos. 2008, Pubmed , Xenbase
Ben-Zvi, Scaling of dorsal-ventral patterning in the Xenopus laevis embryo. 2014, Pubmed , Xenbase
Bennett, Maternal nodal and zebrafish embryogenesis. 2007, Pubmed
Beppu, BMP type II receptor is required for gastrulation and early development of mouse embryos. 2000, Pubmed
Bertocchini, The hypoblast of the chick embryo positions the primitive streak by antagonizing nodal signaling. 2002, Pubmed , Xenbase
Biehs, The Drosophila short gastrulation gene prevents Dpp from autoactivating and suppressing neurogenesis in the neuroectoderm. 1996, Pubmed , Xenbase
Bijakowski, Sizzled is unique among secreted frizzled-related proteins for its ability to specifically inhibit bone morphogenetic protein-1 (BMP-1)/tolloid-like proteinases. 2012, Pubmed , Xenbase
Birsoy, Vg 1 is an essential signaling molecule in Xenopus development. 2006, Pubmed , Xenbase
Bisgrove, Regulation of midline development by antagonism of lefty and nodal signaling. 1999, Pubmed
Bisgrove, Polaris and Polycystin-2 in dorsal forerunner cells and Kupffer's vesicle are required for specification of the zebrafish left-right axis. 2005, Pubmed , Xenbase
Blader, Cleavage of the BMP-4 antagonist chordin by zebrafish tolloid. 1997, Pubmed , Xenbase
Blitz, Is chordin a long-range- or short-range-acting factor? Roles for BMP1-related metalloproteases in chordin and BMP4 autofeedback loop regulation. 2000, Pubmed , Xenbase
Blitz, Twisted gastrulation loss-of-function analyses support its role as a BMP inhibitor during early Xenopus embryogenesis. 2003, Pubmed , Xenbase
Blum, Ciliation and gene expression distinguish between node and posterior notochord in the mammalian embryo. 2007, Pubmed , Xenbase
Blum, Symmetry breakage in the vertebrate embryo: when does it happen and how does it work? 2014, Pubmed , Xenbase
Blum, Xenopus, an ideal model system to study vertebrate left-right asymmetry. 2009, Pubmed , Xenbase
Blum, The evolution and conservation of left-right patterning mechanisms. 2014, Pubmed , Xenbase
Borges, The BMP antagonists cerberus-like and noggin do not interact during mouse forebrain development. 2001, Pubmed
Borges, Goosecoid and cerberus-like do not interact during mouse embryogenesis. 2002, Pubmed
Borovina, Vangl2 directs the posterior tilting and asymmetric localization of motile primary cilia. 2010, Pubmed
Bourillot, A changing morphogen gradient is interpreted by continuous transduction flow. 2002, Pubmed , Xenbase
Bouwmeester, Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer. 1996, Pubmed , Xenbase
Branam, Zebrafish chordin-like and chordin are functionally redundant in regulating patterning of the dorsoventral axis. 2010, Pubmed
Branford, Regulation of gut and heart left-right asymmetry by context-dependent interactions between xenopus lefty and BMP4 signaling. 2000, Pubmed , Xenbase
Branford, Lefty-dependent inhibition of Nodal- and Wnt-responsive organizer gene expression is essential for normal gastrulation. 2002, Pubmed , Xenbase
Branney, Characterisation of the fibroblast growth factor dependent transcriptome in early development. 2009, Pubmed , Xenbase
Brennan, Nodal activity in the node governs left-right asymmetry. 2002, Pubmed
Brennan, Nodal signalling in the epiblast patterns the early mouse embryo. 2001, Pubmed
Brody, Ciliogenesis and left-right axis defects in forkhead factor HFH-4-null mice. 2000, Pubmed
Burdine, Antagonistic interactions in the zebrafish midline prior to the emergence of asymmetric gene expression are important for left-right patterning. 2016, Pubmed
Campione, The homeobox gene Pitx2: mediator of asymmetric left-right signaling in vertebrate heart and gut looping. 1999, Pubmed , Xenbase
Canty, A complete domain structure of Drosophila tolloid is required for cleavage of short gastrulation. 2006, Pubmed
Cao, fgf17b, a novel member of Fgf family, helps patterning zebrafish embryos. 2004, Pubmed
Carmany-Rampey, Single-cell internalization during zebrafish gastrulation. 2001, Pubmed
Carnac, The homeobox gene Siamois is a target of the Wnt dorsalisation pathway and triggers organiser activity in the absence of mesoderm. 1996, Pubmed , Xenbase
Carron, Specification of anteroposterior axis by combinatorial signaling during Xenopus development. 2016, Pubmed , Xenbase
Cha, Wnt5a and Wnt11 interact in a maternal Dkk1-regulated fashion to activate both canonical and non-canonical signaling in Xenopus axis formation. 2008, Pubmed , Xenbase
Cha, Cooperative non-cell and cell autonomous regulation of Nodal gene expression and signaling by Lefty/Antivin and Brachyury in Xenopus. 2006, Pubmed , Xenbase
Chamorro, FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development. 2005, Pubmed , Xenbase
Chang, Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects. 1999, Pubmed
Chang, Regulation of nodal and BMP signaling by tomoregulin-1 (X7365) through novel mechanisms. 2003, Pubmed , Xenbase
Chang, Xenopus GDF6, a new antagonist of noggin and a partner of BMPs. 1999, Pubmed , Xenbase
Chang, Smad5 is essential for left-right asymmetry in mice. 2000, Pubmed
Chang, Smad5 is required for mouse primordial germ cell development. 2001, Pubmed
Chang, Twisted gastrulation can function as a BMP antagonist. 2001, Pubmed , Xenbase
Chen, Two modes by which Lefty proteins inhibit nodal signaling. 2004, Pubmed , Xenbase
Chen, Generation and characterization of Tmeff2 mutant mice. 2012, Pubmed
Chen, A transcriptional partner for MAD proteins in TGF-beta signalling. 1996, Pubmed , Xenbase
Chen, Lefty proteins are long-range inhibitors of squint-mediated nodal signaling. 2002, Pubmed
Chen, The zebrafish Nodal signal Squint functions as a morphogen. 2001, Pubmed
Chen, Mutation of the mouse hepatocyte nuclear factor/forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetry. 1998, Pubmed
Cheng, Lefty blocks a subset of TGFbeta signals by antagonizing EGF-CFC coreceptors. 2004, Pubmed , Xenbase
Cheng, EGF-CFC proteins are essential coreceptors for the TGF-beta signals Vg1 and GDF1. 2003, Pubmed , Xenbase
Cheng, The lefty-related factor Xatv acts as a feedback inhibitor of nodal signaling in mesoderm induction and L-R axis development in xenopus. 2000, Pubmed , Xenbase
Cheyette, Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation. 2002, Pubmed , Xenbase
Chi, A secreted BMP antagonist, Cer1, fine tunes the spatial organization of the ureteric bud tree during mouse kidney development. 2011, Pubmed
Chiodelli, Heparan sulfate proteoglycans mediate the angiogenic activity of the vascular endothelial growth factor receptor-2 agonist gremlin. 2011, Pubmed
Chiu, Genome-wide view of TGFβ/Foxh1 regulation of the early mesendoderm program. 2014, Pubmed , Xenbase
Cho, BMP signal attenuates FGF pathway in anteroposterior neural patterning. 2013, Pubmed , Xenbase
Chocron, Zebrafish Bmp4 regulates left-right asymmetry at two distinct developmental time points. 2007, Pubmed
Choi, Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430. 2007, Pubmed
Chu, Functional redundancy of EGF-CFC genes in epiblast and extraembryonic patterning during early mouse embryogenesis. 2010, Pubmed
Church, Gremlin1 preferentially binds to bone morphogenetic protein-2 (BMP-2) and BMP-4 over BMP-7. 2015, Pubmed
Collart, The novel Smad-interacting protein Smicl regulates Chordin expression in the Xenopus embryo. 2005, Pubmed , Xenbase
Collavin, The secreted Frizzled-related protein Sizzled functions as a negative feedback regulator of extreme ventral mesoderm. 2003, Pubmed , Xenbase
Collignon, Relationship between asymmetric nodal expression and the direction of embryonic turning. 1996, Pubmed
Concha, A nodal signaling pathway regulates the laterality of neuroanatomical asymmetries in the zebrafish forebrain. 2000, Pubmed
Conlon, A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse. 1994, Pubmed
Connors, The role of tolloid/mini fin in dorsoventral pattern formation of the zebrafish embryo. 1999, Pubmed
Connors, Temporal and spatial action of tolloid (mini fin) and chordin to pattern tail tissues. 2006, Pubmed
Constam, SPC4/PACE4 regulates a TGFbeta signaling network during axis formation. 2000, Pubmed
Cooke, Dynamics of the control of body pattern in the development of Xenopus laevis. III. Timing and pattern after u.v. irradiation of the egg and after excision of presumptive head endo-mesoderm. 1985, Pubmed , Xenbase
Cooper, A cluster of noninvoluting endocytic cells at the margin of the zebrafish blastoderm marks the site of embryonic shield formation. 1996, Pubmed
Coucouvanis, BMP signaling plays a role in visceral endoderm differentiation and cavitation in the early mouse embryo. 1999, Pubmed
Cui, Synergistic effects of Vg1 and Wnt signals in the specification of dorsal mesoderm and endoderm. 1996, Pubmed , Xenbase
Cunliffe, Ectopic mesoderm formation in Xenopus embryos caused by widespread expression of a Brachyury homologue. 1992, Pubmed , Xenbase
D'Amico, Spatially distinct domains of cell behavior in the zebrafish organizer region. 1997, Pubmed , Xenbase
Dal-Pra, Noggin1 and Follistatin-like2 function redundantly to Chordin to antagonize BMP activity. 2006, Pubmed , Xenbase
Dale, Secretion and mesoderm-inducing activity of the TGF-beta-related domain of Xenopus Vg1. 1993, Pubmed , Xenbase
Dale, Xolloid-related: a novel BMP1/Tolloid-related metalloprotease is expressed during early Xenopus development. 2002, Pubmed , Xenbase
Danesh, BMP and BMP receptor expression during murine organogenesis. 2009, Pubmed
Danos, Role of notochord in specification of cardiac left-right orientation in zebrafish and Xenopus. 1996, Pubmed , Xenbase
Davidson, The node of the mouse embryo. 2000, Pubmed
Davidson, Impact of node ablation on the morphogenesis of the body axis and the lateral asymmetry of the mouse embryo during early organogenesis. 1999, Pubmed
Davis, BMP receptor IA is required in the mammalian embryo for endodermal morphogenesis and ectodermal patterning. 2004, Pubmed
Davis, The chirality of gut rotation derives from left-right asymmetric changes in the architecture of the dorsal mesentery. 2008, Pubmed
De Groot, Expression patterns of follistatin and two follistatin-related proteins during mouse development. 2000, Pubmed
De Robertis, Evo-devo: variations on ancestral themes. 2008, Pubmed
De Robertis, A common plan for dorsoventral patterning in Bilateria. 1996, Pubmed , Xenbase
De Robertis, The Chordin Morphogenetic Pathway. 2016, Pubmed , Xenbase
De Robertis, Dorsal-ventral patterning and neural induction in Xenopus embryos. 2004, Pubmed , Xenbase
Degenkolbe, A GDF5 point mutation strikes twice--causing BDA1 and SYNS2. 2013, Pubmed
Deglincerti, Coco is a dual activity modulator of TGFβ signaling. 2015, Pubmed , Xenbase
Delaune, Neural induction in Xenopus requires early FGF signalling in addition to BMP inhibition. 2005, Pubmed , Xenbase
Denes, Molecular architecture of annelid nerve cord supports common origin of nervous system centralization in bilateria. 2007, Pubmed
Dewulf, Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis. 1995, Pubmed
Di-Gregorio, BMP signalling inhibits premature neural differentiation in the mouse embryo. 2007, Pubmed
Dick, Essential role of Bmp7 (snailhouse) and its prodomain in dorsoventral patterning of the zebrafish embryo. 2000, Pubmed
Dickmeis, Expression of the anti-dorsalizing morphogenetic protein gene in the zebrafish embryo. 2001, Pubmed , Xenbase
Ding, Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo. 1998, Pubmed
Dionne, Mutation and analysis of Dan, the founding member of the Dan family of transforming growth factor beta antagonists. 2001, Pubmed , Xenbase
Dohrmann, Induction of axial mesoderm by zDVR-1, the zebrafish orthologue of Xenopus Vg1. 1996, Pubmed , Xenbase
Dorey, A novel Cripto-related protein reveals an essential role for EGF-CFCs in Nodal signalling in Xenopus embryos. 2006, Pubmed , Xenbase
Dosch, Requirement for anti-dorsalizing morphogenetic protein in organizer patterning. 2000, Pubmed , Xenbase
Dougan, The role of the zebrafish nodal-related genes squint and cyclops in patterning of mesendoderm. 2003, Pubmed
Duboc, Nodal and BMP2/4 signaling organizes the oral-aboral axis of the sea urchin embryo. 2004, Pubmed
Duboc, Left-right asymmetry in the sea urchin embryo is regulated by nodal signaling on the right side. 2005, Pubmed
Dubrulle, Response to Nodal morphogen gradient is determined by the kinetics of target gene induction. 2015, Pubmed
Dudley, A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. 1995, Pubmed
Dufort, The transcription factor HNF3beta is required in visceral endoderm for normal primitive streak morphogenesis. 1998, Pubmed
Dunn, Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and patterning in the mouse embryo. 2004, Pubmed
Dupont, Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. 2005, Pubmed , Xenbase
Dyson, The interpretation of position in a morphogen gradient as revealed by occupancy of activin receptors. 1998, Pubmed , Xenbase
Ecochard, A novel TGF-beta-like gene, fugacin, specifically expressed in the Spemann organizer of Xenopus. 1995, Pubmed , Xenbase
Eimon, In Xenopus embryos, BMP heterodimers are not required for mesoderm induction, but BMP activity is necessary for dorsal/ventral patterning. 1999, Pubmed , Xenbase
Eivers, Integration of BMP and Wnt signaling via vertebrate Smad1/5/8 and Drosophila Mad. 2009, Pubmed
Engert, Wnt/β-catenin signalling regulates Sox17 expression and is essential for organizer and endoderm formation in the mouse. 2013, Pubmed
Episkopou, Induction of the mammalian node requires Arkadia function in the extraembryonic lineages. 2001, Pubmed , Xenbase
Erter, Zebrafish nodal-related 2 encodes an early mesendodermal inducer signaling from the extraembryonic yolk syncytial layer. 1998, Pubmed
Erter, Wnt8 is required in lateral mesendodermal precursors for neural posteriorization in vivo. 2001, Pubmed , Xenbase
Essner, Mesendoderm and left-right brain, heart and gut development are differentially regulated by pitx2 isoforms. 2000, Pubmed , Xenbase
Essner, Conserved function for embryonic nodal cilia. 2002, Pubmed , Xenbase
Essner, Kupffer's vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut. 2005, Pubmed
Esteves, BMPs regulate msx gene expression in the dorsal neuroectoderm of Drosophila and vertebrates by distinct mechanisms. 2014, Pubmed
Fan, The evolutionary origin of nodal-related genes in teleosts. 2007, Pubmed
Fan, Nodal signals mediate interactions between the extra-embryonic and embryonic tissues in zebrafish. 2007, Pubmed
Fauny, The entire zebrafish blastula-gastrula margin acts as an organizer dependent on the ratio of Nodal to BMP activity. 2009, Pubmed
Faure, Endogenous patterns of TGFbeta superfamily signaling during early Xenopus development. 2000, Pubmed , Xenbase
Feijen, Expression of activin subunits, activin receptors and follistatin in postimplantation mouse embryos suggests specific developmental functions for different activins. 1994, Pubmed
Fekany-Lee, The homeobox gene bozozok promotes anterior neuroectoderm formation in zebrafish through negative regulation of BMP2/4 and Wnt pathways. 2000, Pubmed
Feldman, Lefty antagonism of Squint is essential for normal gastrulation. 2002, Pubmed
Feldman, Morpholino phenocopies of sqt, oep, and ntl mutations. 2001, Pubmed
Feldman, Zebrafish organizer development and germ-layer formation require nodal-related signals. 1998, Pubmed
Feldman, Nodal-related signals establish mesendodermal fate and trunk neural identity in zebrafish. 2000, Pubmed , Xenbase
Ferguson, Decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo. 1992, Pubmed
Finley, The mouse secreted frizzled-related protein 5 gene is expressed in the anterior visceral endoderm and foregut endoderm during early post-implantation development. 2003, Pubmed
Fisher, Loss of cerebum function ventralizes the zebrafish embryo. 1997, Pubmed , Xenbase
Fleming, A role for Vg1/Nodal signaling in specification of the intermediate mesoderm. 2013, Pubmed
Fletcher, The role of FGF signaling in the establishment and maintenance of mesodermal gene expression in Xenopus. 2008, Pubmed , Xenbase
Flores, Osteogenic transcription factor Runx2 is a maternal determinant of dorsoventral patterning in zebrafish. 2008, Pubmed
Francescatto, The activation of membrane targeted CaMK-II in the zebrafish Kupffer's vesicle is required for left-right asymmetry. 2010, Pubmed
Francois, Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene. 1994, Pubmed
Frisch, XBMPRII, a novel Xenopus type II receptor mediating BMP signaling in embryonic tissues. 1998, Pubmed , Xenbase
Fritz, Regulation of the mRNAs encoding proteins of the BMP signaling pathway during the maternal stages of Xenopus development. 2001, Pubmed , Xenbase
Fuerer, Nodal·Gdf1 heterodimers with bound prodomains enable serum-independent nodal signaling and endoderm differentiation. 2014, Pubmed
Fujiwara, Bone morphogenetic protein 4 in the extraembryonic mesoderm is required for allantois development and the localization and survival of primordial germ cells in the mouse. 2001, Pubmed
Fujiwara, Distinct requirements for extra-embryonic and embryonic bone morphogenetic protein 4 in the formation of the node and primitive streak and coordination of left-right asymmetry in the mouse. 2002, Pubmed
Fukumoto, Serotonin signaling is a very early step in patterning of the left-right axis in chick and frog embryos. 2005, Pubmed , Xenbase
Furtado, BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4. 2008, Pubmed
Fürthauer, Fgf signalling controls the dorsoventral patterning of the zebrafish embryo. 2004, Pubmed
Fürthauer, Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling. 2002, Pubmed
Fürthauer, sprouty4 acts in vivo as a feedback-induced antagonist of FGF signaling in zebrafish. 2001, Pubmed
Gage, Dosage requirement of Pitx2 for development of multiple organs. 1999, Pubmed
Gaio, A role of the cryptic gene in the correct establishment of the left-right axis. 1999, Pubmed
Galli, Glypican 4 modulates FGF signalling and regulates dorsoventral forebrain patterning in Xenopus embryos. 2003, Pubmed , Xenbase
Gamse, Early anteroposterior division of the presumptive neurectoderm in Xenopus. 2001, Pubmed , Xenbase
Garcia Abreu, Chordin-like CR domains and the regulation of evolutionarily conserved extracellular signaling systems. 2002, Pubmed
Garric, Pitx2c ensures habenular asymmetry by restricting parapineal cell number. 2014, Pubmed
Gawantka, Antagonizing the Spemann organizer: role of the homeobox gene Xvent-1. 1995, Pubmed , Xenbase
Geach, Molecular determinants of Xolloid action in vivo. 2008, Pubmed , Xenbase
Geng, Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development. 2011, Pubmed
Gerhart, Inversion of the chordate body axis: are there alternatives? 2000, Pubmed
Gerhart, Changing the axis changes the perspective. 2002, Pubmed , Xenbase
Gilardelli, Functional and hierarchical interactions among zebrafish vox/vent homeobox genes. 2004, Pubmed
Glavic, Xiro-1 controls mesoderm patterning by repressing bmp-4 expression in the Spemann organizer. 2001, Pubmed , Xenbase
Glinka, Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. 1998, Pubmed , Xenbase
Glister, Bone morphogenetic protein (BMP) ligands and receptors in bovine ovarian follicle cells: actions of BMP-4, -6 and -7 on granulosa cells and differential modulation of Smad-1 phosphorylation by follistatin. 2004, Pubmed
Glister, Comparison of bioactivities, binding properties and intrafollicular levels of bovine follistatins. 2015, Pubmed
Godsave, Clonal analysis of mesoderm induction in Xenopus laevis. 1989, Pubmed , Xenbase
Goodman, BMP1-related metalloproteinases promote the development of ventral mesoderm in early Xenopus embryos. 1998, Pubmed , Xenbase
Gore, The zebrafish dorsal axis is apparent at the four-cell stage. 2005, Pubmed
Gourronc, Nodal activity around Kupffer's vesicle depends on the T-box transcription factors Notail and Spadetail and on Notch signaling. 2007, Pubmed
Grande, Nodal signalling is involved in left-right asymmetry in snails. 2009, Pubmed
Granier, Nodal cis-regulatory elements reveal epiblast and primitive endoderm heterogeneity in the peri-implantation mouse embryo. 2011, Pubmed
Green, Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm. 1992, Pubmed , Xenbase
Green, Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate. 1990, Pubmed , Xenbase
Gritsman, The EGF-CFC protein one-eyed pinhead is essential for nodal signaling. 1999, Pubmed , Xenbase
Gritsman, Nodal signaling patterns the organizer. 2000, Pubmed , Xenbase
Groppe, Biochemical and biophysical characterization of refolded Drosophila DPP, a homolog of bone morphogenetic proteins 2 and 4. 1998, Pubmed
Groppe, Structural basis of BMP signaling inhibition by Noggin, a novel twelve-membered cystine knot protein. 2003, Pubmed
Groppe, Structural basis of BMP signalling inhibition by the cystine knot protein Noggin. 2002, Pubmed
Gros, Cell movements at Hensen's node establish left/right asymmetric gene expression in the chick. 2009, Pubmed , Xenbase
Gu, The type I activin receptor ActRIB is required for egg cylinder organization and gastrulation in the mouse. 1998, Pubmed
Gu, The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo. 1999, Pubmed
Gurdon, Direct and continuous assessment by cells of their position in a morphogen gradient. 1995, Pubmed
Gurdon, Activin signalling and response to a morphogen gradient. 1994, Pubmed , Xenbase
Guzman-Ayala, Nodal protein processing and fibroblast growth factor 4 synergize to maintain a trophoblast stem cell microenvironment. 2004, Pubmed
Guzman-Ayala, Graded Smad2/3 activation is converted directly into levels of target gene expression in embryonic stem cells. 2009, Pubmed
Gómez-Skarmeta, The Wnt-activated Xiro1 gene encodes a repressor that is essential for neural development and downregulates Bmp4. 2001, Pubmed , Xenbase
Gönczy, Asymmetric cell division and axis formation in the embryo. 2005, Pubmed
Hagos, Time-dependent patterning of the mesoderm and endoderm by Nodal signals in zebrafish. 2007, Pubmed
Hamada, In search of Turing in vivo: understanding Nodal and Lefty behavior. 2012, Pubmed
Hammerschmidt, dino and mercedes, two genes regulating dorsal development in the zebrafish embryo. 1996, Pubmed
Hammerschmidt, Genetic analysis of dorsoventral pattern formation in the zebrafish: requirement of a BMP-like ventralizing activity and its dorsal repressor. 1996, Pubmed
Han, αE-catenin-dependent mechanotransduction is essential for proper convergent extension in zebrafish. 2016, Pubmed
Hanel, Eye and neural defects associated with loss of GDF6. 2006, Pubmed , Xenbase
Hans, Fgf-dependent otic induction requires competence provided by Foxi1 and Dlx3b. 2007, Pubmed
Hansson, A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells. 2009, Pubmed
Harms, Tomoregulin-1 (TMEFF1) inhibits nodal signaling through direct binding to the nodal coreceptor Cripto. 2003, Pubmed , Xenbase
Harvey, Visualisation and quantification of morphogen gradient formation in the zebrafish. 2009, Pubmed
Hashiguchi, Anteroposterior and dorsoventral patterning are coordinated by an identical patterning clock. 2013, Pubmed , Xenbase
Hashimoto, The Cerberus/Dan-family protein Charon is a negative regulator of Nodal signaling during left-right patterning in zebrafish. 2004, Pubmed , Xenbase
Hashimoto, Zebrafish Dkk1 functions in forebrain specification and axial mesendoderm formation. 2000, Pubmed , Xenbase
Hashimoto, Translation of anterior-posterior polarity into left-right polarity in the mouse embryo. 2010, Pubmed
Hashimoto-Partyka, Nodal signaling in Xenopus gastrulae is cell-autonomous and patterned by beta-catenin. 2003, Pubmed , Xenbase
Hata, OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways. 2000, Pubmed , Xenbase
Hatayama, IP3 signaling is required for cilia formation and left-right body axis determination in Xenopus embryos. 2011, Pubmed , Xenbase
Hatta, The cyclops mutation blocks specification of the floor plate of the zebrafish central nervous system. 1991, Pubmed
Heisenberg, The function of silberblick in the positioning of the eye anlage in the zebrafish embryo. 1997, Pubmed
Helde, The DVR-1 (Vg1) transcript of zebrafish is maternally supplied and distributed throughout the embryo. 1993, Pubmed , Xenbase
Hemmati-Brivanlou, A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos. 1992, Pubmed , Xenbase
Hemmati-Brivanlou, Ventral mesodermal patterning in Xenopus embryos: expression patterns and activities of BMP-2 and BMP-4. 1995, Pubmed , Xenbase
Henningfeld, Autoregulation of Xvent-2B; direct interaction and functional cooperation of Xvent-2 and Smad1. 2002, Pubmed , Xenbase
Heymer, The expression pattern of nodal and lefty in the mouse mutant Ft suggests a function in the establishment of handedness. 1997, Pubmed
Hikasa, Regulation of TCF3 by Wnt-dependent phosphorylation during vertebrate axis specification. 2010, Pubmed , Xenbase
Hild, The smad5 mutation somitabun blocks Bmp2b signaling during early dorsoventral patterning of the zebrafish embryo. 1999, Pubmed
Holley, A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin. 1995, Pubmed , Xenbase
Holley, Anterior-posterior differences in vertebrate segments: specification of trunk and tail somites in the zebrafish blastula. 2006, Pubmed
Holley, The Xenopus dorsalizing factor noggin ventralizes Drosophila embryos by preventing DPP from activating its receptor. 1996, Pubmed , Xenbase
Hong, Embryonic mesoderm and endoderm induction requires the actions of non-embryonic Nodal-related ligands and Mxtx2. 2011, Pubmed
Hoodless, FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse. 2001, Pubmed
Hoodless, Dominant-negative Smad2 mutants inhibit activin/Vg1 signaling and disrupt axis formation in Xenopus. 1999, Pubmed , Xenbase
Hoppler, BMP-2/-4 and Wnt-8 cooperatively pattern the Xenopus mesoderm. 1998, Pubmed , Xenbase
Horne-Badovinac, A cellular framework for gut-looping morphogenesis in zebrafish. 2003, Pubmed
Houston, Repression of organizer genes in dorsal and ventral Xenopus cells mediated by maternal XTcf3. 2002, Pubmed , Xenbase
Houston, Cortical rotation and messenger RNA localization in Xenopus axis formation. 2012, Pubmed , Xenbase
Hyatt, The left-right coordinator: the role of Vg1 in organizing left-right axis formation. 1998, Pubmed , Xenbase
Hyatt, Initiation of vertebrate left-right axis formation by maternal Vg1. 1996, Pubmed , Xenbase
Hyde, Regulation of the early expression of the Xenopus nodal-related 1 gene, Xnr1. 2000, Pubmed , Xenbase
Iemura, Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early Xenopus embryo. 1998, Pubmed , Xenbase
Ikeya, Twisted gastrulation mutation suppresses skeletal defect phenotypes in Crossveinless 2 mutant mice. 2008, Pubmed
Ikeya, Cv2, functioning as a pro-BMP factor via twisted gastrulation, is required for early development of nephron precursors. 2010, Pubmed
Ikeya, Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis. 2006, Pubmed
Imai, The homeobox genes vox and vent are redundant repressors of dorsal fates in zebrafish. 2001, Pubmed , Xenbase
Inomata, Scaling of dorsal-ventral patterning by embryo size-dependent degradation of Spemann's organizer signals. 2013, Pubmed , Xenbase
Inomata, Robust stability of the embryonic axial pattern requires a secreted scaffold for chordin degradation. 2008, Pubmed , Xenbase
Inácio, The dynamic right-to-left translocation of Cerl2 is involved in the regulation and termination of Nodal activity in the mouse node. 2013, Pubmed
Irish, The decapentaplegic gene is required for dorsal-ventral patterning of the Drosophila embryo. 1987, Pubmed
Isaacs, Expression of a novel FGF in the Xenopus embryo. A new candidate inducing factor for mesoderm formation and anteroposterior specification. 1992, Pubmed , Xenbase
Jasuja, bmp1 and mini fin are functionally redundant in regulating formation of the zebrafish dorsoventral axis. 2006, Pubmed
Jasuja, Cell-surface heparan sulfate proteoglycans potentiate chordin antagonism of bone morphogenetic protein signaling and are necessary for cellular uptake of chordin. 2004, Pubmed
Ji, Mutations in zebrafish pitx2 model congenital malformations in Axenfeld-Rieger syndrome but do not disrupt left-right placement of visceral organs. 2016, Pubmed
Jia, smad2 and smad3 are required for mesendoderm induction by transforming growth factor-beta/nodal signals in zebrafish. 2008, Pubmed
Jones, Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation. 1995, Pubmed , Xenbase
Joore, Regulation of the zebrafish goosecoid promoter by mesoderm inducing factors and Xwnt1. 1996, Pubmed
Joseph, Mutant Vg1 ligands disrupt endoderm and mesoderm formation in Xenopus embryos. 1998, Pubmed , Xenbase
Jullien, Morphogen gradient interpretation by a regulated trafficking step during ligand-receptor transduction. 2005, Pubmed , Xenbase
Jörnvall, ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in the mouse. 2004, Pubmed
Kang, Siah ubiquitin ligases modulate nodal signaling during zebrafish embryonic development. 2014, Pubmed
Kapp, The integrator complex subunit 6 (Ints6) confines the dorsal organizer in vertebrate embryogenesis. 2013, Pubmed
Karaulanov, Transcriptional regulation of BMP4 synexpression in transgenic Xenopus. 2004, Pubmed , Xenbase
Karlen, A morpholino phenocopy of the cyclops mutation. 2001, Pubmed
Karsenty, BMP 7 is required for nephrogenesis, eye development, and skeletal patterning. 1996, Pubmed
Katada, cDNA cloning and distribution of XEXT1, the Xenopus homologue of EXT1. 2002, Pubmed , Xenbase
Katsu, Multi-modal effects of BMP signaling on Nodal expression in the lateral plate mesoderm during left-right axis formation in the chick embryo. 2013, Pubmed
Katsu, BMP inhibition by DAN in Hensen's node is a critical step for the establishment of left-right asymmetry in the chick embryo. 2012, Pubmed , Xenbase
Kawahara, Antagonistic role of vega1 and bozozok/dharma homeobox genes in organizer formation. 2000, Pubmed
Kawahara, Functional interaction of vega2 and goosecoid homeobox genes in zebrafish. 2000, Pubmed
Kawasumi, Left-right asymmetry in the level of active Nodal protein produced in the node is translated into left-right asymmetry in the lateral plate of mouse embryos. 2011, Pubmed
Kelley, A concentration-dependent endocytic trap and sink mechanism converts Bmper from an activator to an inhibitor of Bmp signaling. 2009, Pubmed
Kelly, Maternally controlled (beta)-catenin-mediated signaling is required for organizer formation in the zebrafish. 2000, Pubmed
Kessler, Induction of dorsal mesoderm by soluble, mature Vg1 protein. 1995, Pubmed , Xenbase
Khan, Pou2, a class V POU-type transcription factor in zebrafish, regulates dorsoventral patterning and convergent extension movement at different blastula stages. 2012, Pubmed
Khokha, Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning. 2003, Pubmed , Xenbase
Khokha, Depletion of three BMP antagonists from Spemann's organizer leads to a catastrophic loss of dorsal structures. 2005, Pubmed , Xenbase
Kim, A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction. 2000, Pubmed , Xenbase
Kim, A complex of BBS1 and NPHP7 is required for cilia motility in zebrafish. 2013, Pubmed
Kimelman, Tales of Tails (and Trunks): Forming the Posterior Body in Vertebrate Embryos. 2016, Pubmed
Kimmel, Cell lineage of zebrafish blastomeres. I. Cleavage pattern and cytoplasmic bridges between cells. 1985, Pubmed
Kimmel, Origin and organization of the zebrafish fate map. 1990, Pubmed
Kimura, Fate and plasticity of the endoderm in the early chick embryo. 2006, Pubmed
Kimura, Visceral endoderm mediates forebrain development by suppressing posteriorizing signals. 2000, Pubmed
King, BMP5 and the molecular, skeletal, and soft-tissue alterations in short ear mice. 1994, Pubmed
Kingsley, The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF beta superfamily. 1992, Pubmed
Kinoshita, The identification of two novel ligands of the FGF receptor by a yeast screening method and their activity in Xenopus development. 1995, Pubmed , Xenbase
Kishigami, BMP signaling and early embryonic patterning. 2005, Pubmed
Kishigami, BMP signaling through ACVRI is required for left-right patterning in the early mouse embryo. 2004, Pubmed
Kishimoto, The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning. 1997, Pubmed
Kitajima, Wnt signaling regulates left-right axis formation in the node of mouse embryos. 2013, Pubmed
Kišonaitė, Structure of Gremlin-1 and analysis of its interaction with BMP-2. 2016, Pubmed
Knöchel, Structure and expression of Xenopus tropicalis BMP-2 and BMP-4 genes. 2001, Pubmed , Xenbase
Kobayashi, Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction. 2009, Pubmed , Xenbase
Kofron, New roles for FoxH1 in patterning the early embryo. 2004, Pubmed , Xenbase
Kofron, Mesoderm induction in Xenopus is a zygotic event regulated by maternal VegT via TGFbeta growth factors. 1999, Pubmed , Xenbase
Koinuma, Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7. 2003, Pubmed
Kolb, Asymmetry in the cerebral hemispheres of the rat, mouse, rabbit, and cat: the right hemisphere is larger. 1982, Pubmed
Komatsu, Cell cycle arrest in node cells governs ciliogenesis at the node to break left-right symmetry. 2011, Pubmed
Koos, The nieuwkoid/dharma homeobox gene is essential for bmp2b repression in the zebrafish pregastrula. 1999, Pubmed
Kovalenko, A role for extracellular and transmembrane domains of Sef in Sef-mediated inhibition of FGF signaling. 2006, Pubmed
Kozmikova, Essential role of Bmp signaling and its positive feedback loop in the early cell fate evolution of chordates. 2013, Pubmed
Kramer, Maternally supplied Smad5 is required for ventral specification in zebrafish embryos prior to zygotic Bmp signaling. 2002, Pubmed
Kramer-Zucker, Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis. 2005, Pubmed
Krebs, Notch signaling regulates left-right asymmetry determination by inducing Nodal expression. 2003, Pubmed
Kreiling, Suppression of the endoplasmic reticulum calcium pump during zebrafish gastrulation affects left-right asymmetry of the heart and brain. 2008, Pubmed
Kudoh, Distinct roles for Fgf, Wnt and retinoic acid in posteriorizing the neural ectoderm. 2002, Pubmed
Kuo, Formation of the embryonic organizer is restricted by the competitive influences of Fgf signaling and the SoxB1 transcription factors. 2013, Pubmed
Kuraku, Genome-wide detection of gene extinction in early mammalian evolution. 2011, Pubmed
Kurata, Visualization of endogenous BMP signaling during Xenopus development. 2001, Pubmed , Xenbase
Kuroda, Neural induction in Xenopus: requirement for ectodermal and endomesodermal signals via Chordin, Noggin, beta-Catenin, and Cerberus. 2004, Pubmed , Xenbase
Kurpios, The direction of gut looping is established by changes in the extracellular matrix and in cell:cell adhesion. 2008, Pubmed
Kurth, Bottle cell formation in relation to mesodermal patterning in the Xenopus embryo. 2000, Pubmed , Xenbase
Kurth, Establishment of mesodermal gene expression patterns in early Xenopus embryos: the role of repression. 2005, Pubmed , Xenbase
LaBonne, Mesoderm induction by activin requires FGF-mediated intracellular signals. 1994, Pubmed , Xenbase
Lacalli, Dorsoventral axis inversion. 1995, Pubmed
Lana-Elola, Noggin null allele mice exhibit a microform of holoprosencephaly. 2011, Pubmed
Langdon, Maternal and zygotic control of zebrafish dorsoventral axial patterning. 2011, Pubmed
Lapraz, Patterning of the dorsal-ventral axis in echinoderms: insights into the evolution of the BMP-chordin signaling network. 2009, Pubmed
Larraín, BMP-binding modules in chordin: a model for signalling regulation in the extracellular space. 2000, Pubmed , Xenbase
Larraín, Proteolytic cleavage of Chordin as a switch for the dual activities of Twisted gastrulation in BMP signaling. 2001, Pubmed , Xenbase
Laurent, Bone morphogenetic protein antagonism of Spemann's organizer is independent of Wnt signaling. 1999, Pubmed , Xenbase
Lawson, Bmp4 is required for the generation of primordial germ cells in the mouse embryo. 1999, Pubmed
Lawson, Cell fate, morphogenetic movement and population kinetics of embryonic endoderm at the time of germ layer formation in the mouse. 1987, Pubmed
Lea, Temporal and spatial expression of FGF ligands and receptors during Xenopus development. 2009, Pubmed , Xenbase
Lee, Direct response elements of BMP within the PV.1A promoter are essential for its transcriptional regulation during early Xenopus development. 2011, Pubmed , Xenbase
Lee, Embryonic dorsal-ventral signaling: secreted frizzled-related proteins as inhibitors of tolloid proteinases. 2006, Pubmed , Xenbase
Lee, Graded Nodal/Activin signaling titrates conversion of quantitative phospho-Smad2 levels into qualitative embryonic stem cell fate decisions. 2011, Pubmed
Lee, Transcriptional regulation of Xbr-1a/Xvent-2 homeobox gene: analysis of its promoter region. 2002, Pubmed , Xenbase
Lee, Enzymatic regulation of pattern: BMP4 binds CUB domains of Tolloids and inhibits proteinase activity. 2009, Pubmed , Xenbase
Lee, Timing of endogenous activin-like signals and regional specification of the Xenopus embryo. 2001, Pubmed , Xenbase
Lee, Inhibition of FGF signaling converts dorsal mesoderm to ventral mesoderm in early Xenopus embryos. 2011, Pubmed , Xenbase
Lekven, Zebrafish wnt8 encodes two wnt8 proteins on a bicistronic transcript and is required for mesoderm and neurectoderm patterning. 2001, Pubmed
Lele, Zebrafish admp is required to restrict the size of the organizer and to promote posterior and ventral development. 2001, Pubmed
Lenhart, Two additional midline barriers function with midline lefty1 expression to maintain asymmetric Nodal signaling during left-right axis specification in zebrafish. 2011, Pubmed
Leung, bozozok directly represses bmp2b transcription and mediates the earliest dorsoventral asymmetry of bmp2b expression in zebrafish. 2003, Pubmed
Levin, A molecular pathway determining left-right asymmetry in chick embryogenesis. 1995, Pubmed
Levin, Left/right patterning signals and the independent regulation of different aspects of situs in the chick embryo. 1997, Pubmed
Levine, GDF3 is a BMP inhibitor that can activate Nodal signaling only at very high doses. 2009, Pubmed , Xenbase
Levy, Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. 2007, Pubmed
Leyns, Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer. 1997, Pubmed , Xenbase
Li, Direct regulation of siamois by VegT is required for axis formation in Xenopus embryo. 2015, Pubmed , Xenbase
Li, Location of transient ectodermal progenitor potential in mouse development. 2013, Pubmed
Liang, Asymmetric nodal signaling in the zebrafish diencephalon positions the pineal organ. 2000, Pubmed
Lin, Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis. 1999, Pubmed , Xenbase
Lindsley, Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm. 2006, Pubmed
Lippok, Pou5f1 protein expression and posttranslational modification during early zebrafish development. 2014, Pubmed
Little, Twisted gastrulation promotes BMP signaling in zebrafish dorsal-ventral axial patterning. 2004, Pubmed
Little, Extracellular modulation of BMP activity in patterning the dorsoventral axis. 2006, Pubmed , Xenbase
Little, Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis. 2009, Pubmed
Liu, Regulation of left-right asymmetry by thresholds of Pitx2c activity. 2001, Pubmed
Liu, FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals. 1999, Pubmed , Xenbase
Liu, Nodal promotes mir206 expression to control convergence and extension movements during zebrafish gastrulation. 2013, Pubmed
Liu, A human Mad protein acting as a BMP-regulated transcriptional activator. 1996, Pubmed , Xenbase
Liu, MicroRNA-206 regulates cell movements during zebrafish gastrulation by targeting prickle1a and regulating c-Jun N-terminal kinase 2 phosphorylation. 2012, Pubmed
Logan, The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric signals. 1998, Pubmed
Lohr, Left-right asymmetry of a nodal-related gene is regulated by dorsoanterior midline structures during Xenopus development. 1997, Pubmed , Xenbase
Long, The zebrafish nodal-related gene southpaw is required for visceral and diencephalic left-right asymmetry. 2003, Pubmed
Loose, A genetic regulatory network for Xenopus mesendoderm formation. 2004, Pubmed , Xenbase
Lopes, Notch signalling regulates left-right asymmetry through ciliary length control. 2010, Pubmed
Lowe, Genetic dissection of nodal function in patterning the mouse embryo. 2001, Pubmed
Lu, Identification and mechanism of regulation of the zebrafish dorsal determinant. 2011, Pubmed
Lu, Multiple roles for Nodal in the epiblast of the mouse embryo in the establishment of anterior-posterior patterning. 2004, Pubmed
Lu, Function of Rieger syndrome gene in left-right asymmetry and craniofacial development. 1999, Pubmed
Luo, BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. 1995, Pubmed
Lustig, A Xenopus nodal-related gene that acts in synergy with noggin to induce complete secondary axis and notochord formation. 1996, Pubmed , Xenbase
Luu, Control of gastrula cell motility by the Goosecoid/Mix.1/ Siamois network: basic patterns and paradoxical effects. 2008, Pubmed , Xenbase
Luxardi, Distinct Xenopus Nodal ligands sequentially induce mesendoderm and control gastrulation movements in parallel to the Wnt/PCP pathway. 2010, Pubmed , Xenbase
Madabhushi, Anterior visceral endoderm directs ventral morphogenesis and placement of head and heart via BMP2 expression. 2011, Pubmed
Maeda, Xmsx-1 modifies mesodermal tissue pattern along dorsoventral axis in Xenopus laevis embryo. 1997, Pubmed , Xenbase
Maegawa, FGF signaling is required for {beta}-catenin-mediated induction of the zebrafish organizer. 2006, Pubmed
Manning, Loss of the ciliary kinase Nek8 causes left-right asymmetry defects. 2013, Pubmed
Manova, mRNAs for activin receptors II and IIB are expressed in mouse oocytes and in the epiblast of pregastrula and gastrula stage mouse embryos. 1995, Pubmed
Marcellini, Evolution of Brachyury proteins: identification of a novel regulatory domain conserved within Bilateria. 2003, Pubmed , Xenbase
Marjoram, Rapid differential transport of Nodal and Lefty on sulfated proteoglycan-rich extracellular matrix regulates left-right asymmetry in Xenopus. 2011, Pubmed , Xenbase
Marom, Temporal analysis of the early BMP functions identifies distinct anti-organizer and mesoderm patterning phases. 2005, Pubmed , Xenbase
Marom, Patterning of the mesoderm involves several threshold responses to BMP-4 and Xwnt-8. 1999, Pubmed , Xenbase
Marques, The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis. 2004, Pubmed
Marszalek, Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II. 1999, Pubmed
Martello, MicroRNA control of Nodal signalling. 2007, Pubmed , Xenbase
Mathieu, Nodal and Fgf pathways interact through a positive regulatory loop and synergize to maintain mesodermal cell populations. 2004, Pubmed
Matsui, Canopy1, a positive feedback regulator of FGF signaling, controls progenitor cell clustering during Kupffer's vesicle organogenesis. 2011, Pubmed
Matsui, Left-right asymmetry in zebrafish. 2012, Pubmed
Matzuk, Multiple defects and perinatal death in mice deficient in follistatin. 1995, Pubmed , Xenbase
Matzuk, Functional analysis of activins during mammalian development. 1995, Pubmed , Xenbase
Maves, Dynamic and sequential patterning of the zebrafish posterior hindbrain by retinoic acid. 2005, Pubmed
Mavrakis, Arkadia enhances Nodal/TGF-beta signaling by coupling phospho-Smad2/3 activity and turnover. 2007, Pubmed
May-Simera, Bbs8, together with the planar cell polarity protein Vangl2, is required to establish left-right asymmetry in zebrafish. 2010, Pubmed
McGrath, Two populations of node monocilia initiate left-right asymmetry in the mouse. 2003, Pubmed
McMahon, Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. 1998, Pubmed
Melby, Patterning the early zebrafish by the opposing actions of bozozok and vox/vent. 2000, Pubmed , Xenbase
Melby, Specification of cell fates at the dorsal margin of the zebrafish gastrula. 1996, Pubmed
Melloy, No turning, a mouse mutation causing left-right and axial patterning defects. 1998, Pubmed
Meno, Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos. 1997, Pubmed , Xenbase
Meno, Diffusion of nodal signaling activity in the absence of the feedback inhibitor Lefty2. 2001, Pubmed
Meno, Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation. 1999, Pubmed
Meno, Left-right asymmetric expression of the TGF beta-family member lefty in mouse embryos. 1996, Pubmed
Meno, lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal. 1998, Pubmed
Michos, Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis. 2004, Pubmed
Mii, Secreted Frizzled-related proteins enhance the diffusion of Wnt ligands and expand their signalling range. 2009, Pubmed , Xenbase
Miller-Bertoglio, Differential regulation of chordin expression domains in mutant zebrafish. 1997, Pubmed , Xenbase
Miller-Bertoglio, Maternal and zygotic activity of the zebrafish ogon locus antagonizes BMP signaling. 1999, Pubmed
Mine, BMP antagonism is required in both the node and lateral plate mesoderm for mammalian left-right axis establishment. 2008, Pubmed
Mishina, Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis. 1995, Pubmed
Mishina, Multiple roles for activin-like kinase-2 signaling during mouse embryogenesis. 1999, Pubmed
Mishina, Generation of Bmpr/Alk3 conditional knockout mice. 2002, Pubmed
Mitola, Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2. 2010, Pubmed
Miura, Bmpr1a is required for proper migration of the AVE through regulation of Dkk1 expression in the pre-streak mouse embryo. 2010, Pubmed
Miura, BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites. 2006, Pubmed
Miya, Functional analysis of an ascidian homologue of vertebrate Bmp-2/Bmp-4 suggests its role in the inhibition of neural fate specification. 1997, Pubmed , Xenbase
Mizoguchi, Fgf signaling negatively regulates Nodal-dependent endoderm induction in zebrafish. 2006, Pubmed
Mochizuki, Xlim-1 and LIM domain binding protein 1 cooperate with various transcription factors in the regulation of the goosecoid promoter. 2000, Pubmed , Xenbase
Molina, Noggin and noggin-like genes control dorsoventral axis regeneration in planarians. 2011, Pubmed , Xenbase
Molina, The BMP pathway is essential for re-specification and maintenance of the dorsoventral axis in regenerating and intact planarians. 2007, Pubmed
Monteiro, Two novel type II receptors mediate BMP signalling and are required to establish left-right asymmetry in zebrafish. 2008, Pubmed
Moos, Anti-dorsalizing morphogenetic protein is a novel TGF-beta homolog expressed in the Spemann organizer. 1995, Pubmed , Xenbase
Moreno-Ayala, PIAS-like protein Zimp7 is required for the restriction of the zebrafish organizer and mesoderm development. 2015, Pubmed
Morokuma, HrNodal, the ascidian nodal-related gene, is expressed in the left side of the epidermis, and lies upstream of HrPitx. 2002, Pubmed
Moser, BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation. 2003, Pubmed , Xenbase
Muller, Left-right asymmetric morphogenesis in the Xenopus digestive system. 2003, Pubmed , Xenbase
Mullins, Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes. 1996, Pubmed
Murakami, Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads. 2003, Pubmed , Xenbase
Muraoka, Sizzled controls dorso-ventral polarity by repressing cleavage of the Chordin protein. 2006, Pubmed
Myers, Bmp activity gradient regulates convergent extension during zebrafish gastrulation. 2002, Pubmed
Müller, Differential diffusivity of Nodal and Lefty underlies a reaction-diffusion patterning system. 2012, Pubmed
Müller, Morphogen transport. 2013, Pubmed
Müller, Direct action of the nodal-related signal cyclops in induction of sonic hedgehog in the ventral midline of the CNS. 2000, Pubmed
Nakamura, Fluid flow and interlinked feedback loops establish left-right asymmetric decay of Cerl2 mRNA. 2012, Pubmed
Nakamura, Tissue- and stage-specific Wnt target gene expression is controlled subsequent to β-catenin recruitment to cis-regulatory modules. 2016, Pubmed , Xenbase
Nakamura, Follistatin, an activin-binding protein, associates with heparan sulfate chains of proteoglycans on follicular granulosa cells. 1991, Pubmed
Nakamura, Generation of robust left-right asymmetry in the mouse embryo requires a self-enhancement and lateral-inhibition system. 2006, Pubmed
Nakayama, A novel chordin-like protein inhibitor for bone morphogenetic proteins expressed preferentially in mesenchymal cell lineages. 2001, Pubmed , Xenbase
Nakayama, A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage. 2004, Pubmed , Xenbase
Naylor, BMP and retinoic acid regulate anterior-posterior patterning of the non-axial mesoderm across the dorsal-ventral axis. 2016, Pubmed
Nesterenko, Affinity of the heparin binding motif of Noggin1 to heparan sulfate and its visualization in the embryonic tissues. , Pubmed , Xenbase
Neugebauer, FGF signalling during embryo development regulates cilia length in diverse epithelia. 2009, Pubmed , Xenbase
New, Differential effects on Xenopus development of interference with type IIA and type IIB activin receptors. 1997, Pubmed , Xenbase
Nguyen, Ventral and lateral regions of the zebrafish gastrula, including the neural crest progenitors, are established by a bmp2b/swirl pathway of genes. 1998, Pubmed , Xenbase
Nicoli, Regulated expression pattern of gremlin during zebrafish development. 2005, Pubmed , Xenbase
Niederländer, Arkadia enhances nodal-related signalling to induce mesendoderm. 2001, Pubmed , Xenbase
Niehrs, Regionally specific induction by the Spemann-Mangold organizer. 2004, Pubmed
Nieto, Reorganizing the organizer 75 years on. 1999, Pubmed , Xenbase
Nikaido, Conservation of BMP signaling in zebrafish mesoderm patterning. 1997, Pubmed , Xenbase
Nojima, Genetic evidence for involvement of maternally derived Wnt canonical signaling in dorsal determination in zebrafish. 2004, Pubmed
Nonaka, De novo formation of left-right asymmetry by posterior tilt of nodal cilia. 2005, Pubmed
Nonaka, Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein. 1998, Pubmed
Nonaka, Determination of left-right patterning of the mouse embryo by artificial nodal flow. 2002, Pubmed
Nonaka, Modification of mouse nodal flow by applying artificial flow. 2009, Pubmed
Norris, The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo. 2002, Pubmed
Norris, Asymmetric and node-specific nodal expression patterns are controlled by two distinct cis-acting regulatory elements. 1999, Pubmed
Nosaka, Mammalian twisted gastrulation is essential for skeleto-lymphogenesis. 2003, Pubmed
Noël, A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality. 2013, Pubmed
Nutt, Xenopus Sprouty2 inhibits FGF-mediated gastrulation movements but does not affect mesoderm induction and patterning. 2001, Pubmed , Xenbase
Oelgeschläger, Chordin is required for the Spemann organizer transplantation phenomenon in Xenopus embryos. 2003, Pubmed , Xenbase
Oelgeschläger, The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling. 2000, Pubmed , Xenbase
Oelgeschläger, The pro-BMP activity of Twisted gastrulation is independent of BMP binding. 2003, Pubmed , Xenbase
Oh, The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse. 1997, Pubmed , Xenbase
Ohi, Anteriorward shifting of asymmetric Xnr1 expression and contralateral communication in left-right specification in Xenopus. 2007, Pubmed , Xenbase
Ohkawara, Role of glypican 4 in the regulation of convergent extension movements during gastrulation in Xenopus laevis. 2003, Pubmed , Xenbase
Oishi, Regulation of primary cilia formation and left-right patterning in zebrafish by a noncanonical Wnt signaling mediator, duboraya. 2006, Pubmed
Okada, Mechanism of nodal flow: a conserved symmetry breaking event in left-right axis determination. 2005, Pubmed
Okada, Abnormal nodal flow precedes situs inversus in iv and inv mice. 1999, Pubmed
Oki, Reversal of left-right asymmetry induced by aberrant Nodal signaling in the node of mouse embryos. 2009, Pubmed
Oki, Sulfated glycosaminoglycans are necessary for Nodal signal transmission from the node to the left lateral plate in the mouse embryo. 2007, Pubmed
Onai, Opposing Nodal/Vg1 and BMP signals mediate axial patterning in embryos of the basal chordate amphioxus. 2010, Pubmed , Xenbase
Onichtchouk, Zebrafish Pou5f1-dependent transcriptional networks in temporal control of early development. 2010, Pubmed
Onichtchouk, The Xvent-2 homeobox gene is part of the BMP-4 signalling pathway controlling [correction of controling] dorsoventral patterning of Xenopus mesoderm. 1996, Pubmed , Xenbase
Onitsuka, Expression and Function of Xmsx-2B in Dorso-Ventral Axis Formation in Gastrula Embryos. 2000, Pubmed , Xenbase
Onuma, XCR2, one of three Xenopus EGF-CFC genes, has a distinct role in the regulation of left-right patterning. 2006, Pubmed , Xenbase
Onuma, Multiple nodal-related genes act coordinately in Xenopus embryogenesis. 2002, Pubmed , Xenbase
Osada, Activin/nodal responsiveness and asymmetric expression of a Xenopus nodal-related gene converge on a FAST-regulated module in intron 1. 2000, Pubmed , Xenbase
Osada, Xenopus nodal-related signaling is essential for mesendodermal patterning during early embryogenesis. 1999, Pubmed , Xenbase
Otsuka, Follistatin inhibits the function of the oocyte-derived factor BMP-15. 2001, Pubmed
Paine-Saunders, Heparan sulfate proteoglycans retain Noggin at the cell surface: a potential mechanism for shaping bone morphogenetic protein gradients. 2002, Pubmed
Papanayotou, A novel nodal enhancer dependent on pluripotency factors and smad2/3 signaling conditions a regulatory switch during epiblast maturation. 2014, Pubmed
Pappano, Use of Bmp1/Tll1 doubly homozygous null mice and proteomics to identify and validate in vivo substrates of bone morphogenetic protein 1/tolloid-like metalloproteinases. 2003, Pubmed
Paulsen, Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes development. 2011, Pubmed , Xenbase
Payne, The role of activin/nodal and Wnt signaling in endoderm formation. 2011, Pubmed
Pelegri, Function of zebrafish beta-catenin and TCF-3 in dorsoventral patterning. 1998, Pubmed
Peng, Lhx5 promotes forebrain development and activates transcription of secreted Wnt antagonists. 2006, Pubmed
Pera, A direct screen for secreted proteins in Xenopus embryos identifies distinct activities for the Wnt antagonists Crescent and Frzb-1. 2000, Pubmed , Xenbase
Perea-Gomez, Role of the anterior visceral endoderm in restricting posterior signals in the mouse embryo. 2001, Pubmed
Perea-Gomez, Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks. 2002, Pubmed
Peterson, Dvr1 transfers left-right asymmetric signals from Kupffer's vesicle to lateral plate mesoderm in zebrafish. 2013, Pubmed , Xenbase
Pfendler, Overexpression of Nodal promotes differentiation of mouse embryonic stem cells into mesoderm and endoderm at the expense of neuroectoderm formation. 2005, Pubmed
Pfirrmann, Molecular mechanism of CHRDL1-mediated X-linked megalocornea in humans and in Xenopus model. 2015, Pubmed , Xenbase
Pi, LRP1-dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis. 2012, Pubmed
Piccolo, Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4. 1996, Pubmed , Xenbase
Piccolo, Cleavage of Chordin by Xolloid metalloprotease suggests a role for proteolytic processing in the regulation of Spemann organizer activity. 1997, Pubmed , Xenbase
Piccolo, The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals. 1999, Pubmed , Xenbase
Piedra, BMP signaling positively regulates Nodal expression during left right specification in the chick embryo. 2002, Pubmed
Piedra, Pitx2 participates in the late phase of the pathway controlling left-right asymmetry. 1998, Pubmed
Piepenburg, Activin redux: specification of mesodermal pattern in Xenopus by graded concentrations of endogenous activin B. 2004, Pubmed , Xenbase
Pinho, Dkk3 is required for TGF-beta signaling during Xenopus mesoderm induction. 2007, Pubmed , Xenbase
Ploper, Dorsal-ventral patterning: Crescent is a dorsally secreted Frizzled-related protein that competitively inhibits Tolloid proteases. 2011, Pubmed , Xenbase
Plouhinec, Chordin forms a self-organizing morphogen gradient in the extracellular space between ectoderm and mesoderm in the Xenopus embryo. 2013, Pubmed , Xenbase
Pogoda, The zebrafish forkhead transcription factor FoxH1/Fast1 is a modulator of nodal signaling required for organizer formation. 2000, Pubmed
Poulain, Mezzo, a paired-like homeobox protein is an immediate target of Nodal signalling and regulates endoderm specification in zebrafish. 2002, Pubmed , Xenbase
Pézeron, Duplicate sfrp1 genes in zebrafish: sfrp1a is dynamically expressed in the developing central nervous system, gut and lateral line. 2006, Pubmed
Ramel, Repression of the vertebrate organizer by Wnt8 is mediated by Vent and Vox. 2004, Pubmed , Xenbase
Ramel, Spatial regulation of BMP activity. 2012, Pubmed , Xenbase
Ramel, The ventral to dorsal BMP activity gradient in the early zebrafish embryo is determined by graded expression of BMP ligands. 2013, Pubmed
Ramel, WNT8 and BMP2B co-regulate non-axial mesoderm patterning during zebrafish gastrulation. 2005, Pubmed
Ramis, Xnrs and activin regulate distinct genes during Xenopus development: activin regulates cell division. 2007, Pubmed , Xenbase
Ramsdell, Cardiac looping and the vertebrate left-right axis: antagonism of left-sided Vg1 activity by a right-sided ALK2-dependent BMP pathway. 1999, Pubmed , Xenbase
Ramsdell, Left-right asymmetry and congenital cardiac defects: getting to the heart of the matter in vertebrate left-right axis determination. 2005, Pubmed
Rana, Targeted deletion of the novel cytoplasmic dynein mD2LIC disrupts the embryonic organiser, formation of the body axes and specification of ventral cell fates. 2004, Pubmed
Range, Cis-regulatory analysis of nodal and maternal control of dorsal-ventral axis formation by Univin, a TGF-beta related to Vg1. 2007, Pubmed
Rankin, Regulation of left-right patterning in mice by growth/differentiation factor-1. 2000, Pubmed
Rankin, A gene regulatory network controlling hhex transcription in the anterior endoderm of the organizer. 2011, Pubmed , Xenbase
Rashbass, A cell autonomous function of Brachyury in T/T embryonic stem cell chimaeras. 1991, Pubmed
Raya, Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos. 2003, Pubmed
Rebagliati, cyclops encodes a nodal-related factor involved in midline signaling. 1998, Pubmed
Rebagliati, Zebrafish nodal-related genes are implicated in axial patterning and establishing left-right asymmetry. 1998, Pubmed , Xenbase
Rebbert, Transcriptional regulation of the Xlim-1 gene by activin is mediated by an element in intron I. 1997, Pubmed , Xenbase
Reid, Transcriptional integration of Wnt and Nodal pathways in establishment of the Spemann organizer. 2012, Pubmed , Xenbase
Reim, Maternal control of vertebrate dorsoventral axis formation and epiboly by the POU domain protein Spg/Pou2/Oct4. 2006, Pubmed
Reim, The POU domain protein spg (pou2/Oct4) is essential for endoderm formation in cooperation with the HMG domain protein casanova. 2004, Pubmed
Reissmann, The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development. 2001, Pubmed , Xenbase
Rentzsch, An ancient chordin-like gene in organizer formation of Hydra. 2007, Pubmed
Rentzsch, Crossveinless 2 is an essential positive feedback regulator of Bmp signaling during zebrafish gastrulation. 2006, Pubmed
Reversade, Regulation of ADMP and BMP2/4/7 at opposite embryonic poles generates a self-regulating morphogenetic field. 2005, Pubmed , Xenbase
Reversade, Depletion of Bmp2, Bmp4, Bmp7 and Spemann organizer signals induces massive brain formation in Xenopus embryos. 2005, Pubmed , Xenbase
Rex, Multiple interactions between maternally-activated signalling pathways control Xenopus nodal-related genes. 2002, Pubmed , Xenbase
Riesgo, The analysis of eight transcriptomes from all poriferan classes reveals surprising genetic complexity in sponges. 2014, Pubmed
Ro, Organizer restriction through modulation of Bozozok stability by the E3 ubiquitin ligase Lnx-like. 2009, Pubmed
Ro, Lnx-2b restricts gsc expression to the dorsal mesoderm by limiting Nodal and Bozozok activity. 2010, Pubmed
Robertson, Dose-dependent Nodal/Smad signals pattern the early mouse embryo. 2014, Pubmed
Rodaway, Induction of the mesendoderm in the zebrafish germ ring by yolk cell-derived TGF-beta family signals and discrimination of mesoderm and endoderm by FGF. 1999, Pubmed
Roelen, Expression of TGF-beta s and their receptors during implantation and organogenesis of the mouse embryo. 1994, Pubmed
Rohr, The nodal pathway acts upstream of hedgehog signaling to specify ventral telencephalic identity. 2001, Pubmed
Rosa, The miR-430/427/302 family controls mesendodermal fate specification via species-specific target selection. 2009, Pubmed , Xenbase
Rosenquist, Visceral endoderm-1 (VE-1): an antigen marker that distinguishes anterior from posterior embryonic visceral endoderm in the early post-implantation mouse embryo. 1995, Pubmed
Roszko, Regulation of convergence and extension movements during vertebrate gastrulation by the Wnt/PCP pathway. 2009, Pubmed
Rubinstein, Genes dependent on zebrafish cyclops function identified by AFLP differential gene expression screen. 2000, Pubmed
Ryan, Pitx2 determines left-right asymmetry of internal organs in vertebrates. 1998, Pubmed , Xenbase
Ryu, Regulation of dharma/bozozok by the Wnt pathway. 2001, Pubmed
Saijoh, Left-right patterning of the mouse lateral plate requires nodal produced in the node. 2003, Pubmed
Saijoh, Two nodal-responsive enhancers control left-right asymmetric expression of Nodal. 2005, Pubmed
Saijoh, Follow your gut: relaying information from the site of left-right symmetry breaking in the mouse. 2014, Pubmed
Saijoh, Left-right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2. 2000, Pubmed , Xenbase
Sako, Optogenetic Control of Nodal Signaling Reveals a Temporal Pattern of Nodal Signaling Regulating Cell Fate Specification during Gastrulation. 2016, Pubmed
Sakuma, Inhibition of Nodal signalling by Lefty mediated through interaction with common receptors and efficient diffusion. 2002, Pubmed , Xenbase
Salic, Sizzled: a secreted Xwnt8 antagonist expressed in the ventral marginal zone of Xenopus embryos. 1997, Pubmed , Xenbase
Sampath, Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling. 1998, Pubmed , Xenbase
Sampath, Functional differences among Xenopus nodal-related genes in left-right axis determination. 1997, Pubmed , Xenbase
Sander, Evo-devo aspects of classical and molecular data in a historical perspective. 2004, Pubmed
Sander, The opposing homeobox genes Goosecoid and Vent1/2 self-regulate Xenopus patterning. 2007, Pubmed , Xenbase
Sarmah, Inositol polyphosphates regulate zebrafish left-right asymmetry. 2005, Pubmed
Sasai, Xenopus chordin: a novel dorsalizing factor activated by organizer-specific homeobox genes. 1994, Pubmed , Xenbase
Sasai, Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus. 1995, Pubmed , Xenbase
Saund, Gut endoderm is involved in the transfer of left-right asymmetry from the node to the lateral plate mesoderm in the mouse embryo. 2012, Pubmed
Schier, The one-eyed pinhead gene functions in mesoderm and endoderm formation in zebrafish and interacts with no tail. 1997, Pubmed
Schier, Mutations affecting the development of the embryonic zebrafish brain. 1996, Pubmed
Schier, Nodal morphogens. 2009, Pubmed
Schier, Nodal signaling in vertebrate development. 2003, Pubmed
Schier, Molecular genetics of axis formation in zebrafish. 2005, Pubmed
Schille, Differential requirement of bone morphogenetic protein receptors Ia (ALK3) and Ib (ALK6) in early embryonic patterning and neural crest development. 2016, Pubmed , Xenbase
Schlange, BMP2 is a positive regulator of Nodal signaling during left-right axis formation in the chicken embryo. 2002, Pubmed
Schmid, Equivalent genetic roles for bmp7/snailhouse and bmp2b/swirl in dorsoventral pattern formation. 2000, Pubmed
Schmidt, Localized BMP-4 mediates dorsal/ventral patterning in the early Xenopus embryo. 1995, Pubmed , Xenbase
Schmierer, Kinetic analysis of Smad nucleocytoplasmic shuttling reveals a mechanism for transforming growth factor beta-dependent nuclear accumulation of Smads. 2005, Pubmed , Xenbase
Schneider, Beta-catenin translocation into nuclei demarcates the dorsalizing centers in frog and fish embryos. 1996, Pubmed , Xenbase
Schneyer, Characterization of unique binding kinetics of follistatin and activin or inhibin in serum. 1994, Pubmed
Schohl, A role for maternal beta-catenin in early mesoderm induction in Xenopus. 2003, Pubmed , Xenbase
Schuler-Metz, The homeodomain transcription factor Xvent-2 mediates autocatalytic regulation of BMP-4 expression in Xenopus embryos. 2000, Pubmed , Xenbase
Schulte-Merker, The zebrafish organizer requires chordino. 1997, Pubmed , Xenbase
Schulte-Merker, no tail (ntl) is the zebrafish homologue of the mouse T (Brachyury) gene. 1994, Pubmed
Schweickert, Differential gene expression of Xenopus Pitx1, Pitx2b and Pitx2c during cement gland, stomodeum and pituitary development. 2001, Pubmed , Xenbase
Schweickert, Cilia-driven leftward flow determines laterality in Xenopus. 2007, Pubmed , Xenbase
Schweickert, The nodal inhibitor Coco is a critical target of leftward flow in Xenopus. 2010, Pubmed , Xenbase
Schweickert, Pitx2 isoforms: involvement of Pitx2c but not Pitx2a or Pitx2b in vertebrate left-right asymmetry. 2000, Pubmed , Xenbase
Scott, Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis. 1999, Pubmed , Xenbase
Scott, Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling. 2001, Pubmed , Xenbase
Seemann, Mutations in GDF5 reveal a key residue mediating BMP inhibition by NOGGIN. 2009, Pubmed
Seiliez, FoxA3 and goosecoid promote anterior neural fate through inhibition of Wnt8a activity before the onset of gastrulation. 2006, Pubmed
Sekiya, Transcriptional regulation of the TGF-beta pseudoreceptor BAMBI by TGF-beta signaling. 2004, Pubmed , Xenbase
Serpe, The BMP-binding protein Crossveinless 2 is a short-range, concentration-dependent, biphasic modulator of BMP signaling in Drosophila. 2008, Pubmed
Shah, Misexpression of chick Vg1 in the marginal zone induces primitive streak formation. 1997, Pubmed , Xenbase
Sharma, Ciliary dysfunction in developmental abnormalities and diseases. 2008, Pubmed
Shawlot, The cerberus-related gene, Cerr1, is not essential for mouse head formation. 2000, Pubmed , Xenbase
Shen, Nodal signaling: developmental roles and regulation. 2007, Pubmed
Shen, A differential display strategy identifies Cryptic, a novel EGF-related gene expressed in the axial and lateral mesoderm during mouse gastrulation. 1997, Pubmed , Xenbase
Shibata, Role of crescent in convergent extension movements by modulating Wnt signaling in early Xenopus embryogenesis. 2005, Pubmed , Xenbase
Shieh, Zygotic expression of Exostosin1 (Ext1) is required for BMP signaling and establishment of dorsal-ventral pattern in Xenopus. 2014, Pubmed , Xenbase
Shih, SoxB1 transcription factors restrict organizer gene expression by repressing multiple events downstream of Wnt signalling. 2010, Pubmed
Shih, Distribution of tissue progenitors within the shield region of the zebrafish gastrula. 1995, Pubmed
Shimizu, Cooperative roles of Bozozok/Dharma and Nodal-related proteins in the formation of the dorsal organizer in zebrafish. 2000, Pubmed
Shimizu, A novel repressor-type homeobox gene, ved, is involved in dharma/bozozok-mediated dorsal organizer formation in zebrafish. 2002, Pubmed
Shimonaka, Follistatin binds to both activin and inhibin through the common subunit. 1991, Pubmed
Shindo, Coordination of cell polarity during Xenopus gastrulation. 2008, Pubmed , Xenbase
Shinya, Zebrafish Dkk1, induced by the pre-MBT Wnt signaling, is secreted from the prechordal plate and patterns the anterior neural plate. 2000, Pubmed , Xenbase
Shiratori, Two-step regulation of left-right asymmetric expression of Pitx2: initiation by nodal signaling and maintenance by Nkx2. 2001, Pubmed , Xenbase
Shiratori, Conserved regulation and role of Pitx2 in situs-specific morphogenesis of visceral organs. 2006, Pubmed
Shiratori, TGFβ signaling in establishing left-right asymmetry. 2014, Pubmed
Shook, Pattern and morphogenesis of presumptive superficial mesoderm in two closely related species, Xenopus laevis and Xenopus tropicalis. 2004, Pubmed , Xenbase
Shook, Urodeles remove mesoderm from the superficial layer by subduction through a bilateral primitive streak. 2002, Pubmed
Sidi, Maternal induction of ventral fate by zebrafish radar. 2003, Pubmed
Sidis, Biological activity of follistatin isoforms and follistatin-like-3 is dependent on differential cell surface binding and specificity for activin, myostatin, and bone morphogenetic proteins. 2006, Pubmed
Silva, Endogenous Cerberus activity is required for anterior head specification in Xenopus. 2003, Pubmed , Xenbase
Sirotkin, bozozok and squint act in parallel to specify dorsal mesoderm and anterior neuroectoderm in zebrafish. 2000, Pubmed
Skromne, A hierarchy of gene expression accompanying induction of the primitive streak by Vg1 in the chick embryo. 2002, Pubmed
Slack, Mesoderm induction by fibroblast growth factor in early Xenopus development. 1990, Pubmed , Xenbase
Slagle, Nodal-dependent mesendoderm specification requires the combinatorial activities of FoxH1 and Eomesodermin. 2011, Pubmed
Smith, Bmp and nodal independently regulate lefty1 expression to maintain unilateral nodal activity during left-right axis specification in zebrafish. 2011, Pubmed
Smith, Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A. 1990, Pubmed , Xenbase
Smith, Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells. 2008, Pubmed
Smith, Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction. 1991, Pubmed , Xenbase
Soares, Bone morphogenetic protein 4 signaling regulates development of the anterior visceral endoderm in the mouse embryo. 2008, Pubmed
Solloway, Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup. 1999, Pubmed
Solloway, Mice lacking Bmp6 function. 1998, Pubmed
Solnica-Krezel, The role of the homeodomain protein Bozozok in zebrafish axis formation. 2001, Pubmed
Song, The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice. 1999, Pubmed , Xenbase
St Amand, Cloning and expression pattern of chicken Pitx2: a new component in the SHH signaling pathway controlling embryonic heart looping. 1998, Pubmed
St Johnston, Decapentaplegic transcripts are localized along the dorsal-ventral axis of the Drosophila embryo. 1987, Pubmed
Stafford, Follistatin interacts with Noggin in the development of the axial skeleton. 2014, Pubmed
Stainier, Cardiovascular development in the zebrafish. I. Myocardial fate map and heart tube formation. 1993, Pubmed
Stickney, Zebrafish bmp4 functions during late gastrulation to specify ventroposterior cell fates. 2007, Pubmed
Stower, Heading forwards: anterior visceral endoderm migration in patterning the mouse embryo. 2014, Pubmed
Stubbs, The forkhead protein Foxj1 specifies node-like cilia in Xenopus and zebrafish embryos. 2008, Pubmed , Xenbase
Su, The evolutionally conserved activity of Dapper2 in antagonizing TGF-beta signaling. 2007, Pubmed , Xenbase
Sudou, Dynamic in vivo binding of transcription factors to cis-regulatory modules of cer and gsc in the stepwise formation of the Spemann-Mangold organizer. 2012, Pubmed , Xenbase
Sulik, Morphogenesis of the murine node and notochordal plate. 1994, Pubmed
Sumi, Defining early lineage specification of human embryonic stem cells by the orchestrated balance of canonical Wnt/beta-catenin, Activin/Nodal and BMP signaling. 2008, Pubmed
Sun, BMP4 activation and secretion are negatively regulated by an intracellular gremlin-BMP4 interaction. 2006, Pubmed
Sun, Activation and roles of ALK4/ALK7-mediated maternal TGFbeta signals in zebrafish embryo. 2006, Pubmed
Supp, Targeted deletion of the ATP binding domain of left-right dynein confirms its role in specifying development of left-right asymmetries. 1999, Pubmed
Suzuki, Xenopus msx1 mediates epidermal induction and neural inhibition by BMP4. 1997, Pubmed , Xenbase
Suzuki, Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila tolloid. 1996, Pubmed
Sylva, Follistatin-like 1 in vertebrate development. 2013, Pubmed
Szeto, The regulation of mesodermal progenitor cell commitment to somitogenesis subdivides the zebrafish body musculature into distinct domains. 2006, Pubmed
Tadjuidje, Nodal signalling in Xenopus: the role of Xnr5 in left/right asymmetry and heart development. 2016, Pubmed , Xenbase
Takahashi, Two novel nodal-related genes initiate early inductive events in Xenopus Nieuwkoop center. 2000, Pubmed , Xenbase
Takaoka, The mouse embryo autonomously acquires anterior-posterior polarity at implantation. 2006, Pubmed
Takaoka, Cell fate decisions and axis determination in the early mouse embryo. 2012, Pubmed
Takeda, Xenopus msx-1 regulates dorso-ventral axis formation by suppressing the expression of organizer genes. 2000, Pubmed , Xenbase
Takeda, A novel POU domain gene, zebrafish pou2: expression and roles of two alternatively spliced twin products in early development. 1994, Pubmed
Takehara-Kasamatsu, Characterization of follistatin-related gene as a negative regulatory factor for activin family members during mouse heart development. 2007, Pubmed
Takemoto, Cilia play a role in breaking left-right symmetry of the sea urchin embryo. 2016, Pubmed
Takeuchi, Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry. 2007, Pubmed
Tallquist, Epiblast-restricted Cre expression in MORE mice: a tool to distinguish embryonic vs. extra-embryonic gene function. 2000, Pubmed
Tanaka, Long-range action of Nodal requires interaction with GDF1. 2007, Pubmed , Xenbase
Tanegashima, Xantivin suppresses the activity of EGF-CFC genes to regulate nodal signaling. 2004, Pubmed , Xenbase
Tanegashima, Expression cloning of Xantivin, a Xenopus lefty/antivin-related gene, involved in the regulation of activin signaling during mesoderm induction. 2000, Pubmed , Xenbase
Tannahill, Localized synthesis of the Vg1 protein during early Xenopus development. 1989, Pubmed , Xenbase
Tao, Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos. 2005, Pubmed , Xenbase
Taulman, Polaris, a protein involved in left-right axis patterning, localizes to basal bodies and cilia. 2001, Pubmed , Xenbase
Technau, Evolutionary crossroads in developmental biology: Cnidaria. 2011, Pubmed
Tendeng, Cloning and embryonic expression of five distinct sfrp genes in the zebrafish Danio rerio. 2006, Pubmed
Thisse, Spatial and temporal expression of the zebrafish genome by large-scale in situ hybridization screening. 2004, Pubmed
Thisse, Formation of the vertebrate embryo: Moving beyond the Spemann organizer. 2015, Pubmed
Thisse, Antivin, a novel and divergent member of the TGFbeta superfamily, negatively regulates mesoderm induction. 1999, Pubmed
Thisse, Activin- and Nodal-related factors control antero-posterior patterning of the zebrafish embryo. 2000, Pubmed
Thompson, The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding. 2005, Pubmed
Thomsen, Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor. 1996, Pubmed , Xenbase
Thomsen, Processed Vg1 protein is an axial mesoderm inducer in Xenopus. 1993, Pubmed , Xenbase
Tian, A temperature-sensitive mutation in the nodal-related gene cyclops reveals that the floor plate is induced during gastrulation in zebrafish. 2003, Pubmed
Tian, Both foxj1a and foxj1b are implicated in left-right asymmetric development in zebrafish embryos. 2009, Pubmed
Tingler, Symmetry breakage in the frog Xenopus: role of Rab11 and the ventral-right blastomere. 2014, Pubmed , Xenbase
Tisler, Cilia are required for asymmetric nodal induction in the sea urchin embryo. 2016, Pubmed
Tiso, BMP signalling regulates anteroposterior endoderm patterning in zebrafish. 2002, Pubmed
Toivonen, Activin A and Wnt-dependent specification of human definitive endoderm cells. 2013, Pubmed
Toyama, Nodal induces ectopic goosecoid and lim1 expression and axis duplication in zebrafish. 1995, Pubmed
Toyoizumi, Xenopus nodal related-1 is indispensable only for left-right axis determination. 2005, Pubmed , Xenbase
Tremblay, Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation. 2001, Pubmed , Xenbase
Tremblay, Formation of the definitive endoderm in mouse is a Smad2-dependent process. 2000, Pubmed
Tribulo, Regulation of Msx genes by a Bmp gradient is essential for neural crest specification. 2003, Pubmed , Xenbase
Trindade, DNA-binding specificity and embryological function of Xom (Xvent-2). 1999, Pubmed , Xenbase
Troilo, Structural characterization of twisted gastrulation provides insights into opposing functions on the BMP signalling pathway. 2016, Pubmed
Troilo, Nanoscale structure of the BMP antagonist chordin supports cooperative BMP binding. 2014, Pubmed
Tsang, Zebrafish nma is involved in TGFbeta family signaling. 2000, Pubmed , Xenbase
Tsang, Identification of Sef, a novel modulator of FGF signalling. 2002, Pubmed , Xenbase
Tuazon, Temporally coordinated signals progressively pattern the anteroposterior and dorsoventral body axes. 2015, Pubmed , Xenbase
Tucker, The BMP signaling gradient patterns dorsoventral tissues in a temporally progressive manner along the anteroposterior axis. 2008, Pubmed
Vandenberg, Rab GTPases are required for early orientation of the left-right axis in Xenopus. 2013, Pubmed , Xenbase
Vandenberg, A unified model for left-right asymmetry? Comparison and synthesis of molecular models of embryonic laterality. 2013, Pubmed
Vandenberg, Perspectives and open problems in the early phases of left-right patterning. 2009, Pubmed
Varga, Chordin expression, mediated by Nodal and FGF signaling, is restricted by redundant function of two beta-catenins in the zebrafish embryo. 2007, Pubmed
Varlet, nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation. 1997, Pubmed
Vick, Flow on the right side of the gastrocoel roof plate is dispensable for symmetry breakage in the frog Xenopus laevis. 2009, Pubmed , Xenbase
Vincent, Cell fate decisions within the mouse organizer are governed by graded Nodal signals. 2003, Pubmed
Vitt, Evolution and classification of cystine knot-containing hormones and related extracellular signaling molecules. 2001, Pubmed
Viviano, Domain-specific modification of heparan sulfate by Qsulf1 modulates the binding of the bone morphogenetic protein antagonist Noggin. 2004, Pubmed
Vonica, The left-right axis is regulated by the interplay of Coco, Xnr1 and derrière in Xenopus embryos. 2007, Pubmed , Xenbase
Vonica, The Xenopus Nieuwkoop center and Spemann-Mangold organizer share molecular components and a requirement for maternal Wnt activity. 2007, Pubmed , Xenbase
Waldrip, Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo. 1998, Pubmed
Walentek, Wnt11b is involved in cilia-mediated symmetry breakage during Xenopus left-right development. 2013, Pubmed , Xenbase
Wall, Mesendoderm induction and reversal of left-right pattern by mouse Gdf1, a Vg1-related gene. 2000, Pubmed , Xenbase
Wang, Tfap2a and Foxd3 regulate early steps in the development of the neural crest progenitor population. 2011, Pubmed
Wang, Extracellular interactions and ligand degradation shape the nodal morphogen gradient. 2016, Pubmed
Wang, Initiation and propagation of posterior to anterior (PA) waves in zebrafish left-right development. 2008, Pubmed
Wang, Analysis of gene function and visualization of cilia-generated fluid flow in Kupffer's vesicle. 2013, Pubmed
Wardle, Bone morphogenetic protein 1 regulates dorsal-ventral patterning in early Xenopus embryos by degrading chordin, a BMP4 antagonist. 1999, Pubmed , Xenbase
Warga, Origin and development of the zebrafish endoderm. 1999, Pubmed
Warga, Cell movements during epiboly and gastrulation in zebrafish. 1990, Pubmed
Warmflash, A method to recapitulate early embryonic spatial patterning in human embryonic stem cells. 2014, Pubmed
Watanabe, Sequential actions of β-catenin and Bmp pattern the oral nerve net in Nematostella vectensis. 2014, Pubmed
Watanabe, The left-right determinant Inversin is a component of node monocilia and other 9+0 cilia. 2003, Pubmed , Xenbase
Watanabe, Nodal signalling determines biradial asymmetry in Hydra. 2014, Pubmed
Wawersik, BMP7 acts in murine lens placode development. 1999, Pubmed
Waxman, Regulation of the early expression patterns of the zebrafish Dishevelled-interacting proteins Dapper1 and Dapper2. 2005, Pubmed
Waxman, Zebrafish Dapper1 and Dapper2 play distinct roles in Wnt-mediated developmental processes. 2004, Pubmed , Xenbase
Weeks, A maternal mRNA localized to the vegetal hemisphere in Xenopus eggs codes for a growth factor related to TGF-beta. 1987, Pubmed , Xenbase
Weisberg, A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis. 1998, Pubmed , Xenbase
Welsh, Integration of left-right Pitx2 transcription and Wnt signaling drives asymmetric gut morphogenesis via Daam2. 2013, Pubmed
Wessely, Neural induction in the absence of mesoderm: beta-catenin-dependent expression of secreted BMP antagonists at the blastula stage in Xenopus. 2001, Pubmed , Xenbase
Wilkinson, Expression pattern of the mouse T gene and its role in mesoderm formation. 1990, Pubmed , Xenbase
Willot, Cooperative action of ADMP- and BMP-mediated pathways in regulating cell fates in the zebrafish gastrula. 2002, Pubmed , Xenbase
Wills, E2a is necessary for Smad2/3-dependent transcription and the direct repression of lefty during gastrulation. 2015, Pubmed , Xenbase
Wills, Bmp signaling is necessary and sufficient for ventrolateral endoderm specification in Xenopus. 2008, Pubmed , Xenbase
Wilm, Radar breaks the fog: insights into dorsoventral patterning in zebrafish. 2003, Pubmed
Wilson, The T gene is necessary for normal mesodermal morphogenetic cell movements during gastrulation. 1995, Pubmed
Winklbauer, Internalizing the vegetal cell mass before and during amphibian gastrulation: vegetal rotation and related movements. 2012, Pubmed , Xenbase
Winklbauer, Mesodermal cell migration during Xenopus gastrulation. 1990, Pubmed , Xenbase
Winnier, Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. 1995, Pubmed
Winstanley, Synthetic enzyme-substrate tethering obviates the Tolloid-ECM interaction during Drosophila BMP gradient formation. 2015, Pubmed
Witta, XIPOU 2 is a potential regulator of Spemann's Organizer. 1997, Pubmed , Xenbase
Wittbrodt, Disruption of mesoderm and axis formation in fish by ectopic expression of activin variants: the role of maternal activin. 1994, Pubmed , Xenbase
Woo, Nodal signaling regulates endodermal cell motility and actin dynamics via Rac1 and Prex1. 2012, Pubmed
Wrana, Mechanism of activation of the TGF-beta receptor. 1994, Pubmed
Xanthos, The roles of three signaling pathways in the formation and function of the Spemann Organizer. 2002, Pubmed , Xenbase
Xie, Twisted gastrulation enhances BMP signaling through chordin dependent and independent mechanisms. 2005, Pubmed
Xu, Construction of a vertebrate embryo from two opposing morphogen gradients. 2014, Pubmed
Xue, Organizer-derived Bmp2 is required for the formation of a correct Bmp activity gradient during embryonic development. 2014, Pubmed
Yabe, FRL-1, a member of the EGF-CFC family, is essential for neural differentiation in Xenopus early development. 2003, Pubmed , Xenbase
Yabe, Ogon/Secreted Frizzled functions as a negative feedback regulator of Bmp signaling. 2003, Pubmed , Xenbase
Yadin, Structural insights into BMP receptors: Specificity, activation and inhibition. 2016, Pubmed
Yamamoto, Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo. 2004, Pubmed
Yamamoto, Suppression of head formation by Xmsx-1 through the inhibition of intracellular nodal signaling. 2001, Pubmed , Xenbase
Yamamoto, Requirement of Xmsx-1 in the BMP-triggered ventralization of Xenopus embryos. 2000, Pubmed , Xenbase
Yamamoto, Antagonism between Smad1 and Smad2 signaling determines the site of distal visceral endoderm formation in the mouse embryo. 2009, Pubmed
Yamanaka, A novel homeobox gene, dharma, can induce the organizer in a non-cell-autonomous manner. 1998, Pubmed , Xenbase
Yan, Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation. 1999, Pubmed
Yao, Kzp controls canonical Wnt8 signaling to modulate dorsoventral patterning during zebrafish gastrulation. 2010, Pubmed
Yao, Crossveinless 2 regulates bone morphogenetic protein 9 in human and mouse vascular endothelium. 2012, Pubmed
Yeo, The role of FAST-1 and Smads in transcriptional regulation by activin during early Xenopus embryogenesis. 1999, Pubmed , Xenbase
Ying, Induction of primordial germ cells from murine epiblasts by synergistic action of BMP4 and BMP8B signaling pathways. 2001, Pubmed
Ying, Cooperation of endoderm-derived BMP2 and extraembryonic ectoderm-derived BMP4 in primordial germ cell generation in the mouse. 2001, Pubmed
Ying, Requirement of Bmp8b for the generation of primordial germ cells in the mouse. 2000, Pubmed
Yokouchi, Antagonistic signaling by Caronte, a novel Cerberus-related gene, establishes left-right asymmetric gene expression. 1999, Pubmed , Xenbase
Yoshiba, Roles of cilia, fluid flow, and Ca2+ signaling in breaking of left-right symmetry. 2014, Pubmed
Yoshiba, Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2. 2012, Pubmed
Yoshikawa, The ActR-I activin receptor protein is expressed in notochord, lens placode and pituitary primordium cells in the mouse embryo. 2000, Pubmed
Yoshioka, Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry. 1998, Pubmed
Yu, An amphioxus nodal gene (AmphiNodal) with early symmetrical expression in the organizer and mesoderm and later asymmetrical expression associated with left-right axis formation. 2002, Pubmed
Yu, Axial patterning in cephalochordates and the evolution of the organizer. 2007, Pubmed
Yuan, Intraciliary calcium oscillations initiate vertebrate left-right asymmetry. 2015, Pubmed
Zakin, Crossveinless-2 is required for the relocalization of Chordin protein within the vertebral field in mouse embryos. 2010, Pubmed
Zakin, Inactivation of mouse Twisted gastrulation reveals its role in promoting Bmp4 activity during forebrain development. 2004, Pubmed , Xenbase
Zakin, Development of the vertebral morphogenetic field in the mouse: interactions between Crossveinless-2 and Twisted Gastrulation. 2008, Pubmed , Xenbase
Zhang, Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development. 1996, Pubmed
Zhang, Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. 2001, Pubmed , Xenbase
Zhang, Positional cloning identifies zebrafish one-eyed pinhead as a permissive EGF-related ligand required during gastrulation. 1998, Pubmed
Zhang, Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation. 2006, Pubmed , Xenbase
Zhang, Analysis of the interaction between heparin and follistatin and heparin and follistatin-ligand complexes using surface plasmon resonance. 2012, Pubmed
Zhang, Binding between Crossveinless-2 and Chordin von Willebrand factor type C domains promotes BMP signaling by blocking Chordin activity. 2010, Pubmed
Zhang, Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors. 2004, Pubmed
Zhang, von Willebrand factor type C domain-containing proteins regulate bone morphogenetic protein signaling through different recognition mechanisms. 2007, Pubmed
Zhao, Consequences of knocking out BMP signaling in the mouse. 2003, Pubmed
Zhou, Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation. 1993, Pubmed , Xenbase
Zinski, TGF-β Family Signaling in Early Vertebrate Development. 2018, Pubmed , Xenbase
Zorn, Anterior endomesoderm specification in Xenopus by Wnt/beta-catenin and TGF-beta signalling pathways. 1999, Pubmed , Xenbase
de Almeida, Unexpected activities of Smad7 in Xenopus mesodermal and neural induction. 2008, Pubmed , Xenbase
van Boxtel, A Temporal Window for Signal Activation Dictates the Dimensions of a Nodal Signaling Domain. 2015, Pubmed
von der Hardt, The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion. 2007, Pubmed