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An,
The cytosolic GH loop regulates the phosphatidylinositol 4,5-bisphosphate-induced gating kinetics of Kir2 channels.
2012, Pubmed
An,
The cytosolic GH loop regulates the phosphatidylinositol 4,5-bisphosphate-induced gating kinetics of Kir2 channels.
2012,
Pubmed
Arnold,
The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling.
2006,
Pubmed
Bavro,
Structure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gating.
2012,
Pubmed
Benkert,
QMEAN: A comprehensive scoring function for model quality assessment.
2008,
Pubmed
Benkert,
Toward the estimation of the absolute quality of individual protein structure models.
2011,
Pubmed
Biasini,
SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information.
2014,
Pubmed
Bichet,
Merging functional studies with structures of inward-rectifier K(+) channels.
2003,
Pubmed
Bordoli,
Protein structure homology modeling using SWISS-MODEL workspace.
2009,
Pubmed
Caplan,
Molecular mechanism of ion-ion and ion-substrate coupling in the Na+-dependent leucine transporter LeuT.
2008,
Pubmed
Clarke,
Domain reorientation and rotation of an intracellular assembly regulate conduction in Kir potassium channels.
2010,
Pubmed
Davies,
Andersen-Tawil syndrome: new potassium channel mutations and possible phenotypic variation.
2005,
Pubmed
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Xenbase
Domene,
Modeling of an ion channel in its open conformation.
2005,
Pubmed
Donaldson,
PIP2 binding residues of Kir2.1 are common targets of mutations causing Andersen syndrome.
2003,
Pubmed
Doupnik,
The inward rectifier potassium channel family.
1995,
Pubmed
Fakler,
Identification of a titratable lysine residue that determines sensitivity of kidney potassium channels (ROMK) to intracellular pH.
1996,
Pubmed
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Xenbase
Feller,
Molecular dynamics simulation of unsaturated lipid bilayers at low hydration: parameterization and comparison with diffraction studies.
1997,
Pubmed
Hansen,
Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2.
2011,
Pubmed
Hibino,
Inwardly rectifying potassium channels: their structure, function, and physiological roles.
2010,
Pubmed
Horn,
Electrifying phosphatases.
2005,
Pubmed
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Xenbase
Huang,
Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma.
1998,
Pubmed
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Xenbase
Humphrey,
VMD: visual molecular dynamics.
1996,
Pubmed
Kubo,
International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels.
2005,
Pubmed
Kubo,
Primary structure and functional expression of a mouse inward rectifier potassium channel.
1993,
Pubmed
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Xenbase
Kuo,
Two different conformational states of the KirBac3.1 potassium channel revealed by electron crystallography.
2005,
Pubmed
Kuo,
Crystal structure of the potassium channel KirBac1.1 in the closed state.
2003,
Pubmed
Lee,
Secondary anionic phospholipid binding site and gating mechanism in Kir2.1 inward rectifier channels.
2013,
Pubmed
Li,
Identification of the Conformational transition pathway in PIP2 Opening Kir Channels.
2015,
Pubmed
Li,
Lack of negatively charged residues at the external mouth of Kir2.2 channels enable the voltage-dependent block by external Mg2+.
2014,
Pubmed
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Xenbase
Lopes,
Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies.
2002,
Pubmed
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Xenbase
Luján,
Organisation of potassium channels on the neuronal surface.
2010,
Pubmed
Ma,
An andersen-Tawil syndrome mutation in Kir2.1 (V302M) alters the G-loop cytoplasmic K+ conduction pathway.
2007,
Pubmed
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Xenbase
MacKerell,
All-atom empirical potential for molecular modeling and dynamics studies of proteins.
1998,
Pubmed
Mackerell,
Extending the treatment of backbone energetics in protein force fields: limitations of gas-phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulations.
2004,
Pubmed
Meng,
The molecular mechanism by which PIP(2) opens the intracellular G-loop gate of a Kir3.1 channel.
2012,
Pubmed
Miyashita,
Localization and developmental changes of the expression of two inward rectifying K(+)-channel proteins in the rat brain.
1997,
Pubmed
Murata,
Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor.
2005,
Pubmed
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Xenbase
Nichols,
Inward rectifier potassium channels.
1997,
Pubmed
Nishida,
Structural basis of inward rectification: cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 A resolution.
2002,
Pubmed
Nishida,
Crystal structure of a Kir3.1-prokaryotic Kir channel chimera.
2007,
Pubmed
Noskov,
Control of ion selectivity in LeuT: two Na+ binding sites with two different mechanisms.
2008,
Pubmed
Pegan,
Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification.
2005,
Pubmed
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Xenbase
Pegan,
Andersen's syndrome mutation effects on the structure and assembly of the cytoplasmic domains of Kir2.1.
2006,
Pubmed
Phillips,
Scalable molecular dynamics with NAMD.
2005,
Pubmed
Prüss,
Differential distribution of individual subunits of strongly inwardly rectifying potassium channels (Kir2 family) in rat brain.
2005,
Pubmed
Rodriguez-Menchaca,
PIP2 controls voltage-sensor movement and pore opening of Kv channels through the S4-S5 linker.
2012,
Pubmed
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Xenbase
Roux,
On the potential functions used in molecular dynamics simulations of ion channels.
2002,
Pubmed
Salo-Ahen,
The active-inactive transition of human thymidylate synthase: targeted molecular dynamics simulations.
2011,
Pubmed
Sansone,
Management and treatment of Andersen-Tawil syndrome (ATS).
2007,
Pubmed
Schlitter,
Targeted molecular dynamics: a new approach for searching pathways of conformational transitions.
1994,
Pubmed
Soom,
Multiple PIP2 binding sites in Kir2.1 inwardly rectifying potassium channels.
2001,
Pubmed
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Xenbase
Suh,
Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate.
2005,
Pubmed
Swartz,
Towards a structural view of gating in potassium channels.
2004,
Pubmed
Tao,
Crystal structure of the eukaryotic strong inward-rectifier K+ channel Kir2.2 at 3.1 A resolution.
2009,
Pubmed
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Xenbase
Whorton,
Crystal structure of the mammalian GIRK2 K+ channel and gating regulation by G proteins, PIP2, and sodium.
2011,
Pubmed
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Xenbase
Whorton,
X-ray structure of the mammalian GIRK2-βγ G-protein complex.
2013,
Pubmed
Xie,
Activation of inwardly rectifying potassium (Kir) channels by phosphatidylinosital-4,5-bisphosphate (PIP2): interaction with other regulatory ligands.
2007,
Pubmed
Zhang,
Activation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions.
1999,
Pubmed
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Xenbase
Zitron,
Human cardiac inwardly rectifying current IKir2.2 is upregulated by activation of protein kinase A.
2004,
Pubmed
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Xenbase
Zubcevic,
Control of KirBac3.1 potassium channel gating at the interface between cytoplasmic domains.
2014,
Pubmed
