XB-ART-53782
Virology
2017 Nov 01;511:309-319. doi: 10.1016/j.virol.2017.06.005.
Show Gene links
Show Anatomy links
Xenopus-FV3 host-pathogen interactions and immune evasion.
Jacques R
,
Edholm ES
,
Jazz S
,
Odalys TL
,
Francisco JA
.
???displayArticle.abstract???
We first review fundamental insights into anti-ranavirus immunity learned with the Xenopus laevis/ranavirus FV3 model that are generally applicable to ectothermic vertebrates. We then further investigate FV3 genes involved in immune evasion. Focusing on FV3 knockout (KO) mutants defective for a putative viral caspase activation and recruitment domain-containing (CARD)-like protein (Δ64R-FV3), a β-hydroxysteroid dehydrogenase homolog (Δ52L-FV3), and an immediate-early18kDa protein (FV3-Δ18K), we assessed the involvement of these viral genes in replication, dissemination and interaction with peritoneal macrophages in tadpole and adult frogs. Our results substantiate the role of 64R and 52L as critical immune evasion genes, promoting persistence and dissemination in the host by counteracting type III IFN in tadpoles and type I IFN in adult frogs. Comparably, the substantial accumulation of genome copy numbers and exacerbation of type I and III IFN gene expression responses but deficient release of infectious virus suggests that 18K is a viral regulatory gene.
???displayArticle.pubmedLink??? 28625407
???displayArticle.pmcLink??? PMC5623633
???displayArticle.link??? Virology
???displayArticle.grants??? [+]
References [+] :
Andino,
Characterization of Frog Virus 3 knockout mutants lacking putative virulence genes.
2015, Pubmed,
Xenbase
Andino, Characterization of Frog Virus 3 knockout mutants lacking putative virulence genes. 2015, Pubmed , Xenbase
Bayley, Susceptibility of the European common frog Rana temporaria to a panel of ranavirus isolates from fish and amphibian hosts. 2013, Pubmed
Besch, Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells. 2009, Pubmed
Blomberg, In vitro evidence for T-B lymphocyte collaboration in the clawed toad, Xenopus. 1980, Pubmed , Xenbase
Brenes, Transmission of ranavirus between ectothermic vertebrate hosts. 2014, Pubmed
Chen, Improved knockout methodology reveals that frog virus 3 mutants lacking either the 18K immediate-early gene or the truncated vIF-2alpha gene are defective for replication and growth in vivo. 2011, Pubmed , Xenbase
Chen, Antiviral immunity in amphibians. 2011, Pubmed , Xenbase
Cheng, Differential transcription of fathead minnow immune-related genes following infection with frog virus 3, an emerging pathogen of ectothermic vertebrates. 2014, Pubmed
Chinchar, Ranaviruses: not just for frogs. 2014, Pubmed
Chinchar, Family Iridoviridae: poor viral relations no longer. 2009, Pubmed
Collins, Amphibian decline and extinction: what we know and what we need to learn. 2010, Pubmed
Cuesta, Transcription of immune genes upon challenge with viral hemorrhagic septicemia virus (VHSV) in DNA vaccinated rainbow trout (Oncorhynchus mykiss). 2009, Pubmed
Daszak, Emerging infectious diseases and amphibian population declines. 1999, Pubmed
De Jesús Andino, Frog Virus 3 dissemination in the brain of tadpoles, but not in adult Xenopus, involves blood brain barrier dysfunction. 2016, Pubmed , Xenbase
De Jesús Andino, Long term effects of carbaryl exposure on antiviral immune responses in Xenopus laevis. 2017, Pubmed , Xenbase
De Jesús Andino, Susceptibility of Xenopus laevis tadpoles to infection by the ranavirus Frog-Virus 3 correlates with a reduced and delayed innate immune response in comparison with adult frogs. 2012, Pubmed , Xenbase
Edholm, Nonclassical MHC class I-dependent invariant T cells are evolutionarily conserved and prominent from early development in amphibians. 2013, Pubmed , Xenbase
Edholm, Nonclassical MHC-Restricted Invariant Vα6 T Cells Are Critical for Efficient Early Innate Antiviral Immunity in the Amphibian Xenopus laevis. 2015, Pubmed , Xenbase
Forzán, Low detection of ranavirus DNA in wild postmetamorphic green frogs, Rana (Lithobates) clamitans, despite previous or concurrent tadpole mortality. 2013, Pubmed
Gantress, Development and characterization of a model system to study amphibian immune responses to iridoviruses. 2003, Pubmed , Xenbase
Gendrault, Penetration and uncoating of frog virus 3 (FV3) in cultured rat Kupffer cells. 1981, Pubmed
Granoff, The isolation and properties of viruses from Rana pipiens: their possible relationship to the renal adenocarcinoma of the leopard frog. 1965, Pubmed
Gray, Ecology and pathology of amphibian ranaviruses. 2009, Pubmed , Xenbase
Grayfer, Distinct functional roles of amphibian (Xenopus laevis) colony-stimulating factor-1- and interleukin-34-derived macrophages. 2015, Pubmed , Xenbase
Grayfer, Mechanisms of amphibian macrophage development: characterization of the Xenopus laevis colony-stimulating factor-1 receptor. 2014, Pubmed , Xenbase
Grayfer, Prominent amphibian (Xenopus laevis) tadpole type III interferon response to the frog virus 3 ranavirus. 2015, Pubmed , Xenbase
Grayfer, Divergent antiviral roles of amphibian (Xenopus laevis) macrophages elicited by colony-stimulating factor-1 and interleukin-34. 2014, Pubmed , Xenbase
Grayfer, The amphibian (Xenopus laevis) type I interferon response to frog virus 3: new insight into ranavirus pathogenicity. 2014, Pubmed , Xenbase
Grayfer, Amphibian macrophage development and antiviral defenses. 2016, Pubmed , Xenbase
Gut, Frog virus 3 induces a fatal hepatitis in rats. 1981, Pubmed
Hausmann, EXPERIMENTAL CHALLENGE STUDY OF FV3-LIKE RANAVIRUS INFECTION IN PREVIOUSLY FV3-LIKE RANAVIRUS INFECTED EASTERN BOX TURTLES (TERRAPENE CAROLINA CAROLINA) TO ASSESS INFECTION AND SURVIVAL. 2015, Pubmed
Hellsten, The genome of the Western clawed frog Xenopus tropicalis. 2010, Pubmed , Xenbase
Hoverman, Phylogeny, life history, and ecology contribute to differences in amphibian susceptibility to ranaviruses. 2011, Pubmed
Huber, Transcriptional regulation of blood formation during Xenopus development. 1998, Pubmed , Xenbase
Jancovich, Innate immune evasion mediated by the Ambystoma tigrinum virus eukaryotic translation initiation factor 2alpha homologue. 2011, Pubmed
Johnson, Ranavirus infection of free-ranging and captive box turtles and tortoises in the United States. 2008, Pubmed
Kawai, The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. 2010, Pubmed
Kawai, The roles of TLRs, RLRs and NLRs in pathogen recognition. 2009, Pubmed
Kik, Ranavirus-associated mass mortality in wild amphibians, the Netherlands, 2010: a first report. 2011, Pubmed
Kolby, First evidence of amphibian chytrid fungus (Batrachochytrium dendrobatidis) and ranavirus in Hong Kong amphibian trade. 2014, Pubmed
Kolby, Rapid Response to Evaluate the Presence of Amphibian Chytrid Fungus (Batrachochytrium dendrobatidis) and Ranavirus in Wild Amphibian Populations in Madagascar. 2015, Pubmed
Koubourli, Immune roles of amphibian (Xenopus laevis) tadpole granulocytes during Frog Virus 3 ranavirus infections. 2017, Pubmed , Xenbase
Landsberg, Co-infection by alveolate parasites and frog virus 3-like ranavirus during an amphibian larval mortality event in Florida, USA. 2013, Pubmed
Mahalingam, Interferon-inducible chemokines and immunity to poxvirus infections. 2000, Pubmed
Maniero, Generation of a long-lasting, protective, and neutralizing antibody response to the ranavirus FV3 by the frog Xenopus. 2006, Pubmed , Xenbase
Mao, Molecular characterization of iridoviruses isolated from sympatric amphibians and fish. 1999, Pubmed
Marr, Localization and differential expression of activation-induced cytidine deaminase in the amphibian Xenopus upon antigen stimulation and during early development. 2007, Pubmed , Xenbase
Meylan, Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. 2005, Pubmed
Moore, Steroid hormone synthesis by a vaccinia enzyme: a new type of virus virulence factor. 1992, Pubmed
Morales, Innate immune responses and permissiveness to ranavirus infection of peritoneal leukocytes in the frog Xenopus laevis. 2010, Pubmed , Xenbase
Morales, Characterization of primary and memory CD8 T-cell responses against ranavirus (FV3) in Xenopus laevis. 2007, Pubmed , Xenbase
Panchanathan, Protective immunity against secondary poxvirus infection is dependent on antibody but not on CD4 or CD8 T-cell function. 2006, Pubmed
Panchanathan, Correlates of protective immunity in poxvirus infection: where does antibody stand? 2008, Pubmed
Price, Collapse of amphibian communities due to an introduced Ranavirus. 2014, Pubmed
Price, A de novo Assembly of the Common Frog (Rana temporaria) Transcriptome and Comparison of Transcription Following Exposure to Ranavirus and Batrachochytrium dendrobatidis. 2015, Pubmed
Reeve, Natural stressors and ranavirus susceptibility in larval wood frogs (Rana sylvatica). 2013, Pubmed
Rhen, Antiinflammatory action of glucocorticoids--new mechanisms for old drugs. 2005, Pubmed
Robert, A prominent role for invariant T cells in the amphibian Xenopus laevis tadpoles. 2014, Pubmed , Xenbase
Robert, Recombinant Ranaviruses for Studying Evolution of Host-Pathogen Interactions in Ectothermic Vertebrates. 2016, Pubmed , Xenbase
Robert, Adaptive immunity and histopathology in frog virus 3-infected Xenopus. 2005, Pubmed , Xenbase
Robert, Xenopus laevis: a possible vector of Ranavirus infection? 2007, Pubmed , Xenbase
Robert, Inflammation-induced reactivation of the ranavirus Frog Virus 3 in asymptomatic Xenopus laevis. 2014, Pubmed , Xenbase
Robert, Comparative and developmental study of the immune system in Xenopus. 2009, Pubmed , Xenbase
Robert, "Ranaviruses: an emerging threat to ectothermic vertebrates" report of the First International Symposium on Ranaviruses, Minneapolis MN July 8, 2011. 2012, Pubmed
Rothenburg, Double-stranded RNA-activated protein kinase PKR of fishes and amphibians: varying the number of double-stranded RNA binding domains and lineage-specific duplications. 2008, Pubmed , Xenbase
Rothenburg, Characterization of a ranavirus inhibitor of the antiviral protein kinase PKR. 2011, Pubmed
Sample, Inhibition of iridovirus protein synthesis and virus replication by antisense morpholino oligonucleotides targeted to the major capsid protein, the 18 kDa immediate-early protein, and a viral homolog of RNA polymerase II. 2007, Pubmed
Session, Genome evolution in the allotetraploid frog Xenopus laevis. 2016, Pubmed , Xenbase
Sifkarovski, Negative effects of low dose atrazine exposure on the development of effective immunity to FV3 in Xenopus laevis. 2014, Pubmed , Xenbase
Somamoto, Antiviral functions of CD8(+) cytotoxic T cells in teleost fish. 2014, Pubmed
Sroller, Effect of 3-beta-hydroxysteroid dehydrogenase gene deletion on virulence and immunogenicity of different vaccinia viruses and their recombinants. 1998, Pubmed
Sun, Characterization of the Rana grylio virus 3beta-hydroxysteroid dehydrogenase and its novel role in suppressing virus-induced cytopathic effect. 2006, Pubmed
Teacher, Evidence for directional selection at a novel major histocompatibility class I marker in wild common frogs (Rana temporaria) exposed to a viral pathogen (Ranavirus). 2009, Pubmed , Xenbase
Wendel, Amphibian (Xenopus laevis) tadpoles and adult frogs mount distinct interferon responses to the Frog Virus 3 ranavirus. 2017, Pubmed , Xenbase