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XB-ART-53796
J Leukoc Biol January 1, 2017; 102 (3): 845-855.

Adipose tissue macrophages develop from bone marrow-independent progenitors in Xenopus laevis and mouse.

Hassnain Waqas SF , Noble A , Hoang AC , Ampem G , Popp M , Strauß S , Guille M , Röszer T .


Abstract
ATMs have a metabolic impact in mammals as they contribute to metabolically harmful AT inflammation. The control of the ATM number may have therapeutic potential; however, information on ATM ontogeny is scarce. Whereas it is thought that ATMs develop from circulating monocytes, various tissue-resident Mϕs are capable of self-renewal and develop from BM-independent progenitors without a monocyte intermediate. Here, we show that amphibian AT contains self-renewing ATMs that populate the AT before the establishment of BM hematopoiesis. Xenopus ATMs develop from progenitors of aVBI. In the mouse, a significant amount of ATM develops from the yolk sac, the mammalian equivalent of aVBI. In summary, this study provides evidence for a prenatal origin of ATMs and shows that the study of amphibian ATMs can enhance the understanding of the role of the prenatal environment in ATM development.

PubMed ID: 28642277
PMC ID: PMC5574031
Article link: J Leukoc Biol
Grant support: [+]
Genes referenced: atm itgam npffr1.1 ptprc rnf128 tal1


Article Images: [+] show captions
References:
Ablamunits, 2007, Pubmed [+]


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