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XB-ART-53817
J Biol Chem. January 1, 2017; 292 (9): 3940-3946.

Unique Contributions of an Arginine Side Chain to Ligand Recognition in a Glutamate-gated Chloride Channel.

Lynagh T , Komnatnyy VV , Pless SA .


Abstract
Our data unveil a surprisingly small contribution of charge at a conserved arginine side chain previously suggested to form a salt bridge with the ligand, glutamate. Instead, our data show that Arg contributes crucially to ligand sensitivity via a hydrogen bond network, where Arg interacts both with agonist and with a conserved Thr side chain within the receptor. Together, the data provide a new explanation for the reliance of neurotransmitter receptors on Arg side chains and highlight the exceptional capacity of unnatural amino acid incorporation for increasing our understanding of ligand recognition.

PubMed ID: 28096462
PMC ID: PMC5339774
Article link: J Biol Chem.



References:
Akahoshi, 2011, Pubmed[+]


Article Images: [+] show captions

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