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Arakawa,
Functional redundancy between DNA ligases I and III in DNA replication in vertebrate cells.
2012, Pubmed,
Xenbase
Arakawa,
Functional redundancy between DNA ligases I and III in DNA replication in vertebrate cells.
2012,
Pubmed
,
Xenbase
Audebert,
Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining.
2004,
Pubmed
Barnes,
Mutations in the DNA ligase I gene of an individual with immunodeficiencies and cellular hypersensitivity to DNA-damaging agents.
1992,
Pubmed
Bentley,
DNA ligase I null mouse cells show normal DNA repair activity but altered DNA replication and reduced genome stability.
2002,
Pubmed
Bonner,
GammaH2AX and cancer.
2008,
Pubmed
Chen,
Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair.
2008,
Pubmed
Cleaver,
Phosphorylated H2Ax is not an unambiguous marker for DNA double-strand breaks.
2011,
Pubmed
Della-Maria,
Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway.
2011,
Pubmed
,
Xenbase
Echtay,
Superoxide activates mitochondrial uncoupling proteins.
2002,
Pubmed
Ellenberger,
Eukaryotic DNA ligases: structural and functional insights.
2008,
Pubmed
Furda,
Oxidants and not alkylating agents induce rapid mtDNA loss and mitochondrial dysfunction.
2012,
Pubmed
Gamper,
ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage.
2013,
Pubmed
Gao,
DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair.
2011,
Pubmed
,
Xenbase
Goodarzi,
ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin.
2008,
Pubmed
Green,
SnapShot: Mitochondrial quality control.
2011,
Pubmed
Guo,
ATM activation by oxidative stress.
2010,
Pubmed
Harrison,
Replication failure, genome instability, and increased cancer susceptibility in mice with a point mutation in the DNA ligase I gene.
2002,
Pubmed
Hlavatá,
The oncogenic RAS2(val19) mutation locks respiration, independently of PKA, in a mode prone to generate ROS.
2003,
Pubmed
Holt,
Unique features of DNA replication in mitochondria: a functional and evolutionary perspective.
2014,
Pubmed
James,
Senescent human fibroblasts show increased glycolysis and redox homeostasis with extracellular metabolomes that overlap with those of irreparable DNA damage, aging, and disease.
2015,
Pubmed
Jones,
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint.
2005,
Pubmed
Lakshmipathy,
Antisense-mediated decrease in DNA ligase III expression results in reduced mitochondrial DNA integrity.
2001,
Pubmed
,
Xenbase
Lakshmipathy,
The human DNA ligase III gene encodes nuclear and mitochondrial proteins.
1999,
Pubmed
,
Xenbase
Latz,
Activation and regulation of the inflammasomes.
2013,
Pubmed
Le Chalony,
Partial complementation of a DNA ligase I deficiency by DNA ligase III and its impact on cell survival and telomere stability in mammalian cells.
2012,
Pubmed
,
Xenbase
Mei,
Reduced mtDNA copy number increases the sensitivity of tumor cells to chemotherapeutic drugs.
2015,
Pubmed
Nakahira,
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome.
2011,
Pubmed
Qian,
Alterations in bioenergetics due to changes in mitochondrial DNA copy number.
2010,
Pubmed
Sabharwal,
Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?
2014,
Pubmed
Sallmyr,
Up-regulation of WRN and DNA ligase IIIalpha in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaks.
2008,
Pubmed
,
Xenbase
Sallmyr,
Internal tandem duplication of FLT3 (FLT3/ITD) induces increased ROS production, DNA damage, and misrepair: implications for poor prognosis in AML.
2008,
Pubmed
Santos,
Cell sorting experiments link persistent mitochondrial DNA damage with loss of mitochondrial membrane potential and apoptotic cell death.
2003,
Pubmed
Santos,
Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells.
2006,
Pubmed
Shiloh,
The ATM protein kinase: regulating the cellular response to genotoxic stress, and more.
2013,
Pubmed
Shimada,
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis.
2012,
Pubmed
Shokolenko,
Oxidative stress induces degradation of mitochondrial DNA.
2009,
Pubmed
Shokolenko,
Mitochondrial DNA ligase is dispensable for the viability of cultured cells but essential for mtDNA maintenance.
2013,
Pubmed
,
Xenbase
Simsek,
Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair.
2011,
Pubmed
,
Xenbase
Simsek,
DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation.
2011,
Pubmed
,
Xenbase
Song,
A conserved physical and functional interaction between the cell cycle checkpoint clamp loader and DNA ligase I of eukaryotes.
2007,
Pubmed
Tann,
Apoptosis induced by persistent single-strand breaks in mitochondrial genome: critical role of EXOG (5'-EXO/endonuclease) in their repair.
2011,
Pubmed
Tobin,
Targeting abnormal DNA double-strand break repair in tyrosine kinase inhibitor-resistant chronic myeloid leukemias.
2013,
Pubmed
Tobin,
Targeting abnormal DNA repair in therapy-resistant breast cancers.
2012,
Pubmed
Turrens,
Mitochondrial formation of reactive oxygen species.
2003,
Pubmed
Vafa,
c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability.
2002,
Pubmed
Viale,
Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function.
2014,
Pubmed
Yakes,
Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress.
1997,
Pubmed
Zhang,
Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments.
2014,
Pubmed
Zhong,
NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.
2016,
Pubmed
Zhou,
A role for mitochondria in NLRP3 inflammasome activation.
2011,
Pubmed
