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XB-ART-5390
Gene Expr Patterns May 1, 2003; 3 (2): 179-92.

The developmental expression of cell cycle regulators in Xenopus laevis.

Vernon AE , Philpott A .


Abstract
Several cyclins and cdks have been cloned in Xenopus, but their developmental expression has not been thoroughly examined. We have analyzed the temporal and spatial expression of cdk1, cdk2, cdk4 and cyclins D1, D2, E, A1, A2 and B1 by in situ hybridization. The transcripts of these cyclins and cdks exhibit striking tissue-restricted expression patterns very early in development that cannot be strictly correlated with proliferation. While the cdks and their activating cyclins are expressed in somewhat overlapping patterns, they are not precisely coincident. Additionally, maternal and zygotic cyclin forms demonstrate markedly different expression patterns.

PubMed ID: 12711547
Article link: Gene Expr Patterns

Genes referenced: ccna1 ccna2 ccnb1 ccnd1 ccnd2 ccne1 cdk1 cdk2 cdk4


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