XB-ART-53969
Mol Cell
2016 Oct 06;641:7-9. doi: 10.1016/j.molcel.2016.09.023.
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Nick Your DNA, Mark Your Chromatin.
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DNA damage induces chemical and structural changes in our chromatin-embedded genome. In a recent issue of Nature Communications, Grundy et al. (2016) identify a role for PARP3 in the repair of single-strand breaks and reveal that PARP3 mono-ADP-ribosylates nucleosomal histone H2B.
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Species referenced: Xenopus laevis
Genes referenced: h2bc21 parp3
References :
Grundy,
PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2).
2018, Pubmed