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Malays J Med Sci
2017 Mar 01;242:94-99. doi: 10.21315/mjms2017.24.2.12.
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The Effect of 4-hydroxybenzaldehyde on the γ-aminobutyric Acid Type A Receptor.
Zhang J
,
Mohamad H
,
Wong JH
,
Bilal M
,
Ismail AHB
,
Lloyd AJ
,
Yusoff AAM
,
Osman H
,
Wong KT
,
Idris Z
,
Abdullah JM
.
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The α1β2γ2 subtype of GABAA receptors is the most commonly found GABAA receptor subtype in the mammalian cortex and hippocampus. It is expressed heterologously in the Xenopus laevis oocyte as a α1β2γ2S/L subtype for application as an in vitro model for the screening of compounds that modulate receptor activities. In fact, 4-hydroxybenzaldehyde (4-HB) has been identified as one of the major components in Dendrocalamus asper bamboo shoots in our previous study, and the current study showed that at 101.7 μM, 4-HB significantly reduced the GABA-induced chloride current of GABAA receptors expressed on Xenopus oocytes, indicating a possible GABAergic antagonistic effect at high concentrations.
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