XB-ART-54026Bioorg Med Chem Lett. January 1, 2017; 27 (18): 4512-4513.
Efficient synthesis of the GABAA receptor agonist trans-4-aminocrotonic acid (TACA).
Investigations into the pharmacology of different types of cys-loop GABA receptor have relied for years on the chemical modification of GABA-like compounds. The GABA metabolite GABOB is an attractive molecule to modify due to its convenient chemical structure. In the process of developing new GABA-mimic compounds from GABOB as a starting compound three small molecule GABA derivatives were synthesized using a variety of chemical transformations. Amongst these, a new and reliable method to synthesize TACA (trans-4-aminocrotonic acid) is reported.
PubMed ID: 28838689
Article link: Bioorg Med Chem Lett.