Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-54026
Bioorg Med Chem Lett. September 15, 2017; 27 (18): 4512-4513.

Efficient synthesis of the GABAA receptor agonist trans-4-aminocrotonic acid (TACA).

Forrester SG , Foster J , Robert S , Salim L , Desaulniers JP .


Abstract
Investigations into the pharmacology of different types of cys-loop GABA receptor have relied for years on the chemical modification of GABA-like compounds. The GABA metabolite GABOB is an attractive molecule to modify due to its convenient chemical structure. In the process of developing new GABA-mimic compounds from GABOB as a starting compound three small molecule GABA derivatives were synthesized using a variety of chemical transformations. Amongst these, a new and reliable method to synthesize TACA (trans-4-aminocrotonic acid) is reported.

PubMed ID: 28838689
Article link: Bioorg Med Chem Lett.



My Xenbase: [ Log-in / Register ]
version: [4.5.0]

Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556