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XB-ART-5415
Development June 1, 2003; 130 (11): 2429-41.

Xenopus Cyr61 regulates gastrulation movements and modulates Wnt signalling.

Latinkic BV , Mercurio S , Bennett B , Hirst EM , Xu Q , Lau LF , Mohun TJ , Smith JC .


Abstract
Cyr61 is a secreted, heparin-binding, extracellular matrix-associated protein whose activities include the promotion of adhesion and chemotaxis, and the stimulation of fibroblast and endothelial cell growth. Many, if not all, of these activities of Cyr61 are mediated through interactions with integrins. We explore the role of Cyr61 in the early development of Xenopus laevis. Gain- and loss-of-function experiments show that Xcyr61 is required for normal gastrulation movements. This role is mediated in part through the adhesive properties of Xcyr61 and its related ability to modulate assembly of the extracellular matrix. In addition, Xcyr61 can, in a context-dependent manner, stimulate or inhibit signalling through the Wnt pathway. These properties of Xcyr61 provide a mechanism for integrating cell signalling, cell adhesion and cell migration during gastrulation.

PubMed ID: 12702657
Article link: Development

Genes referenced: ag1 ccn1 chrd.1 fn1 gsc ins odc1 tbxt
Morpholinos: cyr61 MO1 cyr61 MO2 cyr61 MO3


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