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XB-ART-54394
Biochem Biophys Res Commun January 1, 2018; 495 (3): 2257-2263.

Anosmin-1 is essential for neural crest and cranial placodes formation in Xenopus.

Bae CJ , Hong CS , Saint-Jeannet JP .


Abstract
During embryogenesis vertebrates develop a complex craniofacial skeleton associated with sensory organs. These structures are primarily derived from two embryonic cell populations the neural crest and cranial placodes, respectively. Neural crest cells and cranial placodes are specified through the integrated action of several families of signaling molecules, and the subsequent activation of a complex network of transcription factors. Here we describe the expression and function of Anosmin-1 (Anos1), an extracellular matrix protein, during neural crest and cranial placodes development in Xenopus laevis. Anos1 was identified as a target of Pax3 and Zic1, two transcription factors necessary and sufficient to generate neural crest and cranial placodes. Anos1 is expressed in cranial neural crest progenitors at early neurula stage and in cranial placode derivatives later in development. We show that Anos1 function is required for neural crest and sensory organs development in Xenopus, consistent with the defects observed in Kallmann syndrome patients carrying a mutation in ANOS1. These findings indicate that anos1 has a conserved function in the development of craniofacial structures, and indicate that anos1-depleted Xenopus embryos represent a useful model to analyze the pathogenesis of Kallmann syndrome.

PubMed ID: 29277616
PMC ID: PMC6193491
Article link: Biochem Biophys Res Commun
Grant support: [+]
Genes referenced: anos1 dmrta1 ebf2 emx2 foxe1 foxi4.1 foxi4.2 myc nog odc1 pax3 pax8 six1 snai2 sox10 sox2 sox8 wnt8a zic1
GO keywords: sensory organ development [+]
Morpholinos: anos1 MO1 pax3 MO1 zic1 MO1

Disease Ontology terms: Kallmann syndrome
OMIMs: HYPOGONADOTROPIC HYPOGONADISM 1 WITH OR WITHOUT ANOSMIA; HH1

Article Images: [+] show captions
References:
Aoki, 2003, Pubmed, Xenbase [+]


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