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XB-ART-54428
Int J Pharm 2017 Jun 15;5251:218-225. doi: 10.1016/j.ijpharm.2017.04.046.
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Development of light-driven gas-forming liposomes for efficient tumor treatment.

Lee JM , Youn YS , Lee ES .


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In this study, we report a gas-forming liposome containing 1H-1H-2H-perfluoro-1-hexene (PFH) and gold nanoparticles (AuNPs). These liposomes were rapidly destabilized by external near-infrared (NIR) light, as a result of the vaporization of PFH influenced by an AuNPs-mediated photothermal event. In particular, these liposomes showed the triggered release of the encapsulated d-(KLAKLAK)2 peptide drug. The experimental results demonstrated that the light-irradiated liposomes significantly enhanced in vitro photothermal and d-(KLAKLAK)2 peptide-mediated cell death of CAOV-3 tumor cells.

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Species referenced: Xenopus
Genes referenced: gnas