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XB-ART-54608
Gene Expr Patterns January 1, 2018; 28 54-61.

Expression of the adhesion G protein-coupled receptor A2 (adgra2) during Xenopus laevis development.

Seigfried FA , Dietmann P , Kühl M , Kühl SJ .


Abstract
The adhesion G protein-coupled receptor A2 (Adgra2) is a seven transmembrane receptor that has been described to be a regulator for angiogenesis in mice. Furthermore, the zebrafish ouchless mutant is unable to develop dorsal root ganglia through a disrupted trafficking of Adgra2. Besides RNA sequencing data, nothing is reported about Adgra2 in the south African crawled frog Xenopus laevis. In this study, we investigated for the first time the spatio-temporal expression of adgra2 during early Xenopus embryogenesis in detail. In silico approaches showed that the genomic adgra2 region as well as the Adgra2 protein sequence is highly conserved among different species including Xenopus. RT-PCR experiments confirmed that embryonic adgra2 expression is primarily detected at the beginning of neurulation and is then present throughout the whole Xenopus embryogenesis until stage 42. Whole mount in situ hybridization approaches visualized adgra2 expression in many tissues during Xenopus embryogenesis such as the cardiovascular system including the heart, the migrating neural crest cells and the developing eye including the periocular mesenchyme. Our results indicate a role of Adgra2 for embryogenesis and are a good starting point for further functional studies during early vertebrate development.

PubMed ID: 29462671
Article link: Gene Expr Patterns

Genes referenced: adgra1 adgra2 adgra3 brf2 erlin2 gprc6a loc100493271 npm1 plpbp prl.1 rab11a rab11fip1 shf slc12a3 znf703


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