XB-ART-54612
Genesis
2018 Jun 01;566-7:e23095. doi: 10.1002/dvg.23095.
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Cut loose and run: The complex role of ADAM proteases during neural crest cell development.
Alfandari D
,
Taneyhill LA
.
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ADAM metalloproteases have been shown to play critical roles during development. In this review, we will describe functional evidence that implicates ADAM proteins during the genesis, migration and differentiation of neural crest cells. We will restrict our analysis to the transmembrane ADAMs as other reviews have addressed the role of extracellular metalloproteases (Christian et al. [2013] Critical Reviews in Biochemistry and Molecular Biology 48:544-560). This review will describe advances that have been obtained mainly through the use of two vertebrate model systems, the frog, and avian embryos. The role of the principal substrates of ADAMs, the cadherins, has been extensively described in other reviews, most recently in (Cousin [1997] Mechanisms of Development 148:79-88; Taneyhill and Schiffmacher [2017] Genesis, 55). The function of ADAMs in the migration of other cell types, including the immune system, wound healing and cancer has been described previously in (Dreymueller et al. [2017] Mediators of Inflammation 2017: 9621724). Our goal is to illustrate both the importance of ADAMs in controlling neural crest behavior and how neural crest cells have helped us understand the molecular interactions, substrates, and functions of ADAM proteins in vivo.
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???displayArticle.grants??? [+]
R01 DE016289 NIDCR NIH HHS, R01 DE024217 NIDCR NIH HHS, R24 OD021485 NIH HHS
References [+] :
Abbruzzese,
The Wnt receptor Frizzled-4 modulates ADAM13 metalloprotease activity.
2015, Pubmed,
Xenbase
Abbruzzese, The Wnt receptor Frizzled-4 modulates ADAM13 metalloprotease activity. 2015, Pubmed , Xenbase
Abbruzzese, ADAM13 cleavage of cadherin-11 promotes CNC migration independently of the homophilic binding site. 2016, Pubmed , Xenbase
Abbruzzese, GSK3 and Polo-like kinase regulate ADAM13 function during cranial neural crest cell migration. 2014, Pubmed , Xenbase
Alfandari, Integrin alpha5beta1 supports the migration of Xenopus cranial neural crest on fibronectin. 2003, Pubmed , Xenbase
Alfandari, ADAM 13: a novel ADAM expressed in somitic mesoderm and neural crest cells during Xenopus laevis development. 1997, Pubmed , Xenbase
Alfandari, Xenopus ADAM 13 is a metalloprotease required for cranial neural crest-cell migration. 2001, Pubmed , Xenbase
Atapattu, The role of proteases in regulating Eph/ephrin signaling. 2014, Pubmed
Bahm, PDGF controls contact inhibition of locomotion by regulating N-cadherin during neural crest migration. 2017, Pubmed , Xenbase
Barrallo-Gimeno, The Snail genes as inducers of cell movement and survival: implications in development and cancer. 2005, Pubmed
Blobel, Functional processing of fertilin: evidence for a critical role of proteolysis in sperm maturation and activation. 2000, Pubmed
Brouxhon, Soluble-E-cadherin activates HER and IAP family members in HER2+ and TNBC human breast cancers. 2014, Pubmed
Brouxhon, Soluble E-cadherin: a critical oncogene modulating receptor tyrosine kinases, MAPK and PI3K/Akt/mTOR signaling. 2014, Pubmed
Cai, MMP-2 expression during early avian cardiac and neural crest morphogenesis. 2000, Pubmed
Cai, Neural crest-specific and general expression of distinct metalloprotease-disintegrins in early Xenopus laevis development. 1998, Pubmed , Xenbase
Chen, ADAM33 is not essential for growth and development and does not modulate allergic asthma in mice. 2006, Pubmed
Cho, Testicular and epididymal ADAMs: expression and function during fertilization. 2012, Pubmed
Christian, The ADAM family: Insights into Notch proteolysis. 2012, Pubmed
Christian, Extracellular metalloproteinases in neural crest development and craniofacial morphogenesis. 2013, Pubmed
Cobaleda, Function of the zinc-finger transcription factor SNAI2 in cancer and development. 2007, Pubmed
Coles, A critical role for Cadherin6B in regulating avian neural crest emigration. 2007, Pubmed
Cousin, ADAM13 function is required in the 3 dimensional context of the embryo during cranial neural crest cell migration in Xenopus laevis. 2012, Pubmed , Xenbase
Cousin, PACSIN2 is a regulator of the metalloprotease/disintegrin ADAM13. 2000, Pubmed , Xenbase
Cousin, Translocation of the cytoplasmic domain of ADAM13 to the nucleus is essential for Calpain8-a expression and cranial neural crest cell migration. 2011, Pubmed , Xenbase
Cousin, Cadherins function during the collective cell migration of Xenopus Cranial Neural Crest cells: revisiting the role of E-cadherin. 2017, Pubmed , Xenbase
Dady, Cadherin interplay during neural crest segregation from the non-neural ectoderm and neural tube in the early chick embryo. 2017, Pubmed
Dady, Timing and kinetics of E- to N-cadherin switch during neurulation in the avian embryo. 2012, Pubmed
Dreymueller, Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases. 2017, Pubmed
Dreymueller, The role of ADAM-mediated shedding in vascular biology. 2012, Pubmed
Duong, MMP-2 plays an essential role in producing epithelial-mesenchymal transformations in the avian embryo. 2004, Pubmed
Evans, Mouse sperm-egg plasma membrane interactions: analysis of roles of egg integrins and the mouse sperm homologue of PH-30 (fertilin) beta. 1995, Pubmed
Evans, Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization. 2001, Pubmed
Ferber, A role for the cleaved cytoplasmic domain of E-cadherin in the nucleus. 2008, Pubmed
Figueiredo, PFKFB4 control of AKT signaling is essential for premigratory and migratory neural crest formation. 2017, Pubmed , Xenbase
Gandhi, Optimization of CRISPR/Cas9 genome editing for loss-of-function in the early chick embryo. 2017, Pubmed
Gaultier, ADAM13 disintegrin and cysteine-rich domains bind to the second heparin-binding domain of fibronectin. 2002, Pubmed , Xenbase
Giebeler, A Disintegrin and Metalloprotease (ADAM): Historical Overview of Their Functions. 2016, Pubmed
Gutiérrez, Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanisms involved in microvessel damage. 2005, Pubmed
Hall, ADAM 10: an active metalloprotease expressed during avian epithelial morphogenesis. 2003, Pubmed
Hartmann, Who decides when to cleave an ectodomain? 2013, Pubmed
Huang, E-cadherin is required for cranial neural crest migration in Xenopus laevis. 2016, Pubmed , Xenbase
Hundhausen, The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion. 2003, Pubmed
Kashef, Cadherin-11 regulates protrusive activity in Xenopus cranial neural crest cells upstream of Trio and the small GTPases. 2009, Pubmed , Xenbase
Khedgikar, Dual control of pcdh8l/PCNS expression and function in Xenopus laevis neural crest cells by adam13/33 via the transcription factors tfap2α and arid3a. 2017, Pubmed , Xenbase
Koehler, Loss of Xenopus cadherin-11 leads to increased Wnt/β-catenin signaling and up-regulation of target genes c-myc and cyclin D1 in neural crest. 2013, Pubmed , Xenbase
Komatsu, Meltrin beta expressed in cardiac neural crest cells is required for ventricular septum formation of the heart. 2007, Pubmed
Langhe, Cadherin-11 localizes to focal adhesions and promotes cell-substrate adhesion. 2016, Pubmed , Xenbase
Lee, Cell delamination in the mesencephalic neural fold and its implication for the origin of ectomesenchyme. 2013, Pubmed
Lewis, Isolation and embryonic expression of avian ADAM 12 and ADAM 19. 2004, Pubmed
Li, Xenopus ADAM19 regulates Wnt signaling and neural crest specification by stabilizing ADAM13. 2018, Pubmed , Xenbase
Lin, Regionalized expression of ADAM13 during chicken embryonic development. 2007, Pubmed
Marambaud, A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. 2002, Pubmed
Marambaud, A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations. 2003, Pubmed
Maretzky, ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation. 2005, Pubmed
Mathavan, The ectodomain of cadherin-11 binds to erbB2 and stimulates Akt phosphorylation to promote cranial neural crest cell migration. 2017, Pubmed , Xenbase
McCusker, Extracellular cleavage of cadherin-11 by ADAM metalloproteases is essential for Xenopus cranial neural crest cell migration. 2009, Pubmed , Xenbase
McLennan, VEGF signals induce trailblazer cell identity that drives neural crest migration. 2015, Pubmed
Monsonego-Ornan, Matrix metalloproteinase 9/gelatinase B is required for neural crest cell migration. 2012, Pubmed
Nakagawa, Neural crest cell-cell adhesion controlled by sequential and subpopulation-specific expression of novel cadherins. 1995, Pubmed
Nakagawa, Neural crest emigration from the neural tube depends on regulated cadherin expression. 1998, Pubmed
Neuner, Xenopus ADAM19 is involved in neural, neural crest and muscle development. 2009, Pubmed , Xenbase
Pan, Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis. 1997, Pubmed , Xenbase
Pollheimer, Review: the ADAM metalloproteinases - novel regulators of trophoblast invasion? 2014, Pubmed
Roth, A new role of the membrane-type matrix metalloproteinase 16 (MMP16/MT3-MMP) in neural crest cell migration. 2017, Pubmed
Sadot, Inhibition of beta-catenin-mediated transactivation by cadherin derivatives. 1998, Pubmed
Sakai, Regulation of Slug transcription in embryonic ectoderm by beta-catenin-Lef/Tcf and BMP-Smad signaling. 2005, Pubmed
Schiffmacher, Cadherin-6B is proteolytically processed during epithelial-to-mesenchymal transitions of the cranial neural crest. 2014, Pubmed
Schiffmacher, Cadherin-6B proteolysis promotes the neural crest cell epithelial-to-mesenchymal transition through transcriptional regulation. 2016, Pubmed
Schulz, ADAM10 regulates endothelial permeability and T-Cell transmigration by proteolysis of vascular endothelial cadherin. 2008, Pubmed
Sela-Donenfeld, Regulation of the onset of neural crest migration by coordinated activity of BMP4 and Noggin in the dorsal neural tube. 1999, Pubmed
Session, Genome evolution in the allotetraploid frog Xenopus laevis. 2016, Pubmed , Xenbase
Shoval, Antagonistic roles of full-length N-cadherin and its soluble BMP cleavage product in neural crest delamination. 2007, Pubmed
Smith, The cysteine-rich domain regulates ADAM protease function in vivo. 2002, Pubmed , Xenbase
Strobl-Mazzulla, A PHD12-Snail2 repressive complex epigenetically mediates neural crest epithelial-to-mesenchymal transition. 2012, Pubmed
Tan, ADAM10 is essential for cranial neural crest-derived maxillofacial bone development. 2016, Pubmed
Taneyhill, Snail2 directly represses cadherin6B during epithelial-to-mesenchymal transitions of the neural crest. 2007, Pubmed
Taneyhill, Should I stay or should I go? Cadherin function and regulation in the neural crest. 2017, Pubmed
Uemura, Activity-dependent regulation of beta-catenin via epsilon-cleavage of N-cadherin. 2006, Pubmed
Umland, Mouse ADAM33: two splice variants differ in protein maturation and localization. 2004, Pubmed
Umland, Human ADAM33 messenger RNA expression profile and post-transcriptional regulation. 2003, Pubmed
Wei, ADAM13 induces cranial neural crest by cleaving class B Ephrins and regulating Wnt signaling. 2010, Pubmed , Xenbase
Wu, Snail: More than EMT. 2010, Pubmed
Yan, Regional expression of ADAM19 during chicken embryonic development. 2011, Pubmed
del Barrio, Overexpression of Snail family members highlights their ability to promote chick neural crest formation. 2002, Pubmed
van der Vorst, A disintegrin and metalloproteases: molecular scissors in angiogenesis, inflammation and atherosclerosis. 2012, Pubmed