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PLoS One January 1, 2018; 13 (4): e0193606.

An atlas of Wnt activity during embryogenesis in Xenopus tropicalis.

Borday C , Parain K , Thi Tran H , Vleminckx K , Perron M , Monsoro-Burq AH .

Wnt proteins form a family of highly conserved secreted molecules that are critical mediators of cell-cell signaling during embryogenesis. Partial data on Wnt activity in different tissues and at different stages have been reported in frog embryos. Our objective here is to provide a coherent and detailed description of Wnt activity throughout embryo development. Using a transgenic Xenopus tropicalis line carrying a Wnt-responsive reporter sequence, we depict the spatial and temporal dynamics of canonical Wnt activity during embryogenesis. We provide a comprehensive series of in situ hybridization in whole-mount embryos and in cross-sections, from gastrula to tadpole stages, with special focus on neural tube, retina and neural crest cell development. This collection of patterns will thus constitute a valuable resource for developmental biologists to picture the dynamics of Wnt activity during development.

PubMed ID: 29672592
Article link: PLoS One

Genes referenced: egr2 en2 fezf2 otx2 pax3 rpe snai2 sox2 wnt1

Article Images: [+] show captions
References [+] :
Al Alam, Contrasting expression of canonical Wnt signaling reporters TOPGAL, BATGAL and Axin2(LacZ) during murine lung development and repair. 2012, Pubmed

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