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XB-ART-54838
Dev Growth Differ May 1, 2018; 60 (4): 226-238.

Roles of Xenopus chemokine ligand CXCLh (XCXCLh) in early embryogenesis.



Abstract
Several chemokine molecules control cell movements during early morphogenesis. However, it is unclear whether chemokine molecules affect cell fate. Here, we identified and characterized the CXC-type chemokine ligand in Xenopus laevis, Xenopus CXCLh (XCXCLh), during early embryogenesis. XCXCLh is expressed in the dorsal vegetal region at the gastrula stage. Both overexpression and knockdown of XCXCLh in the dorsal region inhibited gastrulation. XCXCLh contributed to the attraction of mesendodermal cells and accelerated the reassembly of scratched culture cells. Also, XCXCLh contributed to early endodermal induction. Overexpression of VegTmRNA or high concentrations of calcium ions induced XCXCLh expression. XCXCLh may play roles in both cell movements and differentiation during early Xenopus embryogenesis.

PubMed ID: 29700804
Article link: Dev Growth Differ

Genes referenced: ag1 bmp4 cer1 chrd.1 creb1 cxcl10 cxcl11 dkk1 fn1 frzb krt12.4 mixer myod1 nodal6 otx2 pitx1 sox17a srf vegt xa-1
GO keywords: chemokine activity [+]
Morpholinos: cxcl11 MO1


Article Images: [+] show captions


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