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XB-ART-54854
Dev Biol January 1, 2018; 439 (2): 80-91.

The left-right asymmetry of liver lobation is generated by Pitx2c-mediated asymmetries in the hepatic diverticulum.



Abstract
Internal organs exhibit left-right asymmetric sizes, shapes and anatomical positions, but how these different lateralities develop is poorly understood. Here we use the experimentally tractable Xenopus model to uncover the morphogenetic events that drive the left-right asymmetrical lobation of the liver. On the right side of the early hepatic diverticulum, endoderm cells become columnar and apically constricted, forming an expanded epithelial surface and, ultimately, an enlarged right liver lobe. In contrast, the cells on the left side become rounder, and rearrange into a compact, stratified architecture that produces a smaller left lobe. Side-specific gain- and loss-of-function studies reveal that asymmetric expression of the left-right determinant Pitx2c elicits distinct epithelial morphogenesis events in the left side of the diverticulum. Surprisingly, the cellular events induced by Pitx2c during liver development are opposite those induced in other digestive organs, suggesting divergent cellular mechanisms underlie the formation of different lateralities.

PubMed ID: 29709601
PMC ID: PMC5988353
Article link: Dev Biol
Grant support: [+]
Genes referenced: fga h3-3a hhex itgb1 pitx2
GO keywords: morphogenesis of an epithelium [+]
Antibodies: H3f3a Ab9 Itgb1 Ab1
Morpholinos: pitx2 MO2 pitx2 MO3


Article Images: [+] show captions
References:
Abdel-Misih, 2010, Pubmed [+]


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