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Science January 1, 2018; 360 (6392):

The dynamics of gene expression in vertebrate embryogenesis at single-cell resolution.

Briggs JA , Weinreb C , Wagner DE , Megason S , Peshkin L , Kirschner MW , Klein AM .

Time series of single-cell transcriptome measurements can reveal dynamic features of cell differentiation pathways. From measurements of whole frog embryos spanning zygotic genome activation through early organogenesis, we derived a detailed catalog of cell states in vertebrate development and a map of differentiation across all lineages over time. The inferred map recapitulates most if not all developmental relationships and associates new regulators and marker genes with each cell state. We find that many embryonic cell states appear earlier than previously appreciated. We also assess conflicting models of neural crest development. Incorporating a matched time series of zebrafish development from a companion paper, we reveal conserved and divergent features of vertebrate early developmental gene expression programs.

PubMed ID: 29700227
PMC ID: PMC6038144
Article link: Science
Grant support: [+]
Genes referenced: ets1 etv2 foxd3 id3 myc snai1 tfap2a ventx2.2

GEO Series: GSE113074: NCBI

Article Images: [+] show captions
References [+] :
, Update on activities at the Universal Protein Resource (UniProt) in 2013. 2013, Pubmed

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