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XB-ART-5493
Curr Biol 2003 Apr 01;137:R273-5. doi: 10.1016/s0960-9822(03)00199-4.
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Notch signaling: endocytosis makes delta signal better.

Le Borgne R , Schweisguth F .


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Endocytosis of cell surface receptors is involved in down-regulation of receptor activity. Recent findings indicate that, paradoxically, endocytosis of a membrane-spanning ligand may up-regulate receptor activity: the zebrafish E3 ligase Mind bomb promotes the endocytosis of Delta and is required for efficient activation of Notch.

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Species referenced: Xenopus
Genes referenced: notch1 wwc2