XB-ART-5493
Curr Biol
2003 Apr 01;137:R273-5. doi: 10.1016/s0960-9822(03)00199-4.
Show Gene links
Show Anatomy links
Notch signaling: endocytosis makes delta signal better.
???displayArticle.abstract???
Endocytosis of cell surface receptors is involved in down-regulation of receptor activity. Recent findings indicate that, paradoxically, endocytosis of a membrane-spanning ligand may up-regulate receptor activity: the zebrafish E3 ligase Mind bomb promotes the endocytosis of Delta and is required for efficient activation of Notch.
???displayArticle.pubmedLink??? 12676105
???displayArticle.link??? Curr Biol
Species referenced: Xenopus
Genes referenced: notch1 wwc2