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Curr Biol April 1, 2003; 13 (7): R273-5.

Notch signaling: endocytosis makes delta signal better.

Le Borgne R , Schweisguth F .

Endocytosis of cell surface receptors is involved in down-regulation of receptor activity. Recent findings indicate that, paradoxically, endocytosis of a membrane-spanning ligand may up-regulate receptor activity: the zebrafish E3 ligase Mind bomb promotes the endocytosis of Delta and is required for efficient activation of Notch.

PubMed ID: 12676105
Article link: Curr Biol

Species referenced: Xenopus laevis
Genes referenced: notch1 wwc2