XB-ART-55004Data Brief April 1, 2018; 17 559-563.
Genome-wide transcriptomics analysis of genes regulated by GATA4, 5 and 6 during cardiomyogenesis in Xenopus laevis.
The transcription factors GATA4, GATA5 and GATA6 play important roles in heart muscle differentiation. The data presented in this article are related to the research article entitled "Genome-wide transcriptomics analysis identifies sox7 and sox18 as specifically regulated by gata4 in cardiomyogenesis" (Afouda et al., 2017) . The present study identifies genes regulated by these individual cardiogenic GATA factors using genome-wide transcriptomics analysis. We have presented genes that are specifically regulated by each of them, as well those regulated by either of them. The gene ontology terms (GO) associated with the genes differentially affected are also presented. The data set will allow further investigations on the gene regulatory network downstream of individual cardiogenic GATA factors during cardiac muscle formation.
PubMed ID: 29876429
Article link: Data Brief
Genes referenced: gata4 gata5 gata6 sox18 sox7
GO keywords: cardiac muscle cell development
Morpholinos: gata4 MO4 gata5 MO4 gata6 MO1 gata6 MO2 sox18 MO1 sox7 MO1
Article Images: [+] show captions
|Fig. 1.Venn diagrams of numbers of genes that are differentially expressed compared to Activin-injected control with at least a two-fold reduction in expression and an adjusted p value of 0.05. A: gata-dependent genes with decreased expression insingle gata4, gata5 or gata6 knockdown, respectively (for list of genes, seeTable 1). B: gata dependent genes with decreasedexpression in triple gata4, gata5 or gata6 knockdown compared to those with decreased expression in single gata4, gata5 and gata6 knockdown, respectively (for list of genes, seeTable 2).|