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XB-ART-55051
Gene Expr Patterns January 1, 2018; 29 72-81.
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ADAMTS9, a member of the ADAMTS family, in Xenopus development.

Desanlis I , Felstead HL , Edwards DR , Wheeler GN .


Abstract
Extracellular matrix (ECM) remodeling by metalloproteinases is crucial during development. The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin type I motifs) enzymes are secreted, multi-domain matrix-associated zinc metalloendopeptidases that have diverse roles in tissue morphogenesis and patho-physiological remodeling. The human family includes 19 members. In this study we identified the 19 members of the ADAMTS family in Xenopus laevis and Xenopus tropicalis. Gene identification and a phylogenetic study revealed strong conservation of the ADAMTS family and contributed to a better annotation of the Xenopus genomes. Expression of the entire ADAMTS family was studied from early stages to tadpole stages of Xenopus, and detailed analysis of ADAMTS9 revealed expression in many structures during organogenesis such as neural crest (NC) derivative tissues, the pronephros and the pancreas. Versican, a matrix component substrate of ADAMTS9 shows a similar expression pattern suggesting a role of ADAMTS9 in the remodeling of the ECM in these structures by degradation of versican.

PubMed ID: 29935379
PMC ID: PMC6119763
Article link: Gene Expr Patterns
Grant support: [+]

Species referenced: Xenopus tropicalis Xenopus laevis
Genes referenced: adam28.2 adamts1 adamts10 adamts12 adamts13 adamts14 adamts15 adamts16 adamts17 adamts18 adamts19 adamts2 adamts20 adamts3 adamts4 adamts5 adamts6 adamts7 adamts8 adamts9 crebbp odc1 vcan


Article Images: [+] show captions
References [+] :
Boerboom, Partially redundant functions of Adamts1 and Adamts4 in the perinatal development of the renal medulla. 2011, Pubmed