Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Dev Biol
2018 Dec 01;444 Suppl 1:S181-S192. doi: 10.1016/j.ydbio.2018.06.012.
Show Gene links
Show Anatomy links
Early specification and development of rabbit neural crest cells.
Betters E
,
Charney RM
,
Garcia-Castro MI
.
???displayArticle.abstract???
The phenomenal migratory and differentiation capacity of neural crest cells has been well established across model organisms. While the earliest stages of neural crest development have been investigated in non-mammalian model systems such as Xenopus and Aves, the early specification of this cell population has not been evaluated in mammalian embryos, of which the murine model is the most prevalent. Towards a more comprehensive understanding of mammalian neural crest formation and human comparative studies, we have used the rabbit as a mammalian system for the study of early neural crest specification and development. We examine the expression profile of well-characterized neural crest markers in rabbit embryos across developmental time from early gastrula to later neurula stages, and provide a comparison to markers of migratory neural crest in the chick. Importantly, we apply explant specification assays to address the pivotal question of mammalian neural crest ontogeny, and provide the first evidence that a specified population of neural crest cells exists in the rabbit gastrula prior to the overt expression of neural crest markers. Finally, we demonstrate that FGF signaling is necessary for early rabbit neural crest formation, as SU5402 treatment strongly represses neural crest marker expression in explant assays. This study pioneers the rabbit as a model for neural crest development, and provides the first demonstration of mammalian neural crest specification and the requirement of FGF signaling in this process.
Abu-Issa,
Fgf8 is required for pharyngeal arch and cardiovascular development in the mouse.
2002, Pubmed
Abu-Issa,
Fgf8 is required for pharyngeal arch and cardiovascular development in the mouse.
2002,
Pubmed
Anderson,
Phenotypes of neural-crest-derived cells in vagal and sacral pathways.
2006,
Pubmed
Bang,
Expression of Pax-3 is initiated in the early neural plate by posteriorizing signals produced by the organizer and by posterior non-axial mesoderm.
1997,
Pubmed
,
Xenbase
Barriga,
Animal models for studying neural crest development: is the mouse different?
2015,
Pubmed
,
Xenbase
Basch,
Specification of the neural crest occurs during gastrulation and requires Pax7.
2006,
Pubmed
Berg,
Trophectoderm lineage determination in cattle.
2011,
Pubmed
Berke,
The development of the rostral neuraxis and neural crest in the rabbit embryo up to 16 somites.
1965,
Pubmed
Betancur,
Assembling neural crest regulatory circuits into a gene regulatory network.
2010,
Pubmed
Betters,
Analysis of early human neural crest development.
2010,
Pubmed
Billon,
The generation of adipocytes by the neural crest.
2007,
Pubmed
Bolande,
Neurocristopathy: its growth and development in 20 years.
1997,
Pubmed
Bondurand,
Expression of the SOX10 gene during human development.
1998,
Pubmed
Bronner-Fraser,
Analysis of the early stages of trunk neural crest migration in avian embryos using monoclonal antibody HNK-1.
1986,
Pubmed
Carneiro,
Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication.
2014,
Pubmed
Carter,
Animal models of human placentation--a review.
2007,
Pubmed
Chai,
Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis.
2000,
Pubmed
Chambers,
Dual-SMAD Inhibition/WNT Activation-Based Methods to Induce Neural Crest and Derivatives from Human Pluripotent Stem Cells.
2016,
Pubmed
Correia,
Bmp2 is required for migration but not for induction of neural crest cells in the mouse.
2007,
Pubmed
Couly,
Mapping of the early neural primordium in quail-chick chimeras. II. The prosencephalic neural plate and neural folds: implications for the genesis of cephalic human congenital abnormalities.
1987,
Pubmed
Debbache,
Cre-driver lines used for genetic fate mapping of neural crest cells in the mouse: An overview.
2018,
Pubmed
Enders,
What can comparative studies of placental structure tell us?--A review.
2004,
Pubmed
Etchevers,
Molecular bases of human neurocristopathies.
2006,
Pubmed
Farlie,
The neural crest: basic biology and clinical relationships in the craniofacial and enteric nervous systems.
2004,
Pubmed
Feistel,
Gap junctions relay FGF8-mediated right-sided repression of Nodal in rabbit.
2008,
Pubmed
Fischer,
FGF8 acts as a right determinant during establishment of the left-right axis in the rabbit.
2002,
Pubmed
Frank,
An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome.
2002,
Pubmed
Fukuta,
Derivation of mesenchymal stromal cells from pluripotent stem cells through a neural crest lineage using small molecule compounds with defined media.
2014,
Pubmed
García-Castro,
Ectodermal Wnt function as a neural crest inducer.
2002,
Pubmed
Green,
The lamprey: a jawless vertebrate model system for examining origin of the neural crest and other vertebrate traits.
2014,
Pubmed
HAMBURGER,
A series of normal stages in the development of the chick embryo.
1951,
Pubmed
Hackland,
Top-Down Inhibition of BMP Signaling Enables Robust Induction of hPSCs Into Neural Crest in Fully Defined, Xeno-free Conditions.
2017,
Pubmed
Hong,
Fgf8a induces neural crest indirectly through the activation of Wnt8 in the paraxial mesoderm.
2008,
Pubmed
,
Xenbase
Idkowiak,
Hypoblast controls mesoderm generation and axial patterning in the gastrulating rabbit embryo.
2004,
Pubmed
,
Xenbase
Khudyakov,
Comprehensive spatiotemporal analysis of early chick neural crest network genes.
2009,
Pubmed
Knezevic,
Two novel chick T-box genes related to mouse Brachyury are expressed in different, non-overlapping mesodermal domains during gastrulation.
1997,
Pubmed
Knoetgen,
Head induction in the chick by primitive endoderm of mammalian, but not avian origin.
1999,
Pubmed
Knoetgen,
Anterior neural induction by nodes from rabbits and mice.
2000,
Pubmed
Lawson,
Clonal analysis of epiblast fate during germ layer formation in the mouse embryo.
1991,
Pubmed
Lee,
Isolation and directed differentiation of neural crest stem cells derived from human embryonic stem cells.
2007,
Pubmed
Leung,
WNT/β-catenin signaling mediates human neural crest induction via a pre-neural border intermediate.
2016,
Pubmed
Li,
Neural crest expression of Cre recombinase directed by the proximal Pax3 promoter in transgenic mice.
2000,
Pubmed
Lumsden,
Segmental origin and migration of neural crest cells in the hindbrain region of the chick embryo.
1991,
Pubmed
Mancilla,
Neural crest formation in Xenopus laevis: mechanisms of Xslug induction.
1996,
Pubmed
,
Xenbase
Matsuoka,
Neural crest origins of the neck and shoulder.
2005,
Pubmed
Mayor,
Induction of the prospective neural crest of Xenopus.
1995,
Pubmed
,
Xenbase
McBride,
Thalidomide embryopathy.
1977,
Pubmed
McKeown,
Sox10 overexpression induces neural crest-like cells from all dorsoventral levels of the neural tube but inhibits differentiation.
2005,
Pubmed
Menendez,
Wnt signaling and a Smad pathway blockade direct the differentiation of human pluripotent stem cells to multipotent neural crest cells.
2011,
Pubmed
Mica,
Modeling neural crest induction, melanocyte specification, and disease-related pigmentation defects in hESCs and patient-specific iPSCs.
2013,
Pubmed
Mohammadi,
Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.
1997,
Pubmed
Monsoro-Burq,
Neural crest induction by paraxial mesoderm in Xenopus embryos requires FGF signals.
2003,
Pubmed
,
Xenbase
Morrison,
Prospective identification, isolation by flow cytometry, and in vivo self-renewal of multipotent mammalian neural crest stem cells.
1999,
Pubmed
Murray,
Snail family genes are required for left-right asymmetry determination, but not neural crest formation, in mice.
2006,
Pubmed
Nichols,
Neural crest formation in the head of the mouse embryo as observed using a new histological technique.
1981,
Pubmed
Nikitina,
Dissecting early regulatory relationships in the lamprey neural crest gene network.
2008,
Pubmed
O'Rahilly,
The development of the neural crest in the human.
2007,
Pubmed
Ota,
Hagfish embryology with reference to the evolution of the neural crest.
2007,
Pubmed
Patthey,
Early development of the central and peripheral nervous systems is coordinated by Wnt and BMP signals.
2008,
Pubmed
Patthey,
Wnt-regulated temporal control of BMP exposure directs the choice between neural plate border and epidermal fate.
2009,
Pubmed
Patthey,
Specification and regionalisation of the neural plate border.
2011,
Pubmed
Pearn,
The rabbit thalidomide embryopathy.
1966,
Pubmed
Peeters,
Neurulation in the rabbit embryo.
1998,
Pubmed
Piliszek,
Suppression of ERK signalling abolishes primitive endoderm formation but does not promote pluripotency in rabbit embryo.
2017,
Pubmed
Plöger,
Pitx2 and nodal as conserved early markers of the anterior-posterior axis in the rabbit embryo.
2018,
Pubmed
Prasad,
Induction of the neural crest state: control of stem cell attributes by gene regulatory, post-transcriptional and epigenetic interactions.
2012,
Pubmed
,
Xenbase
Püschel,
The rabbit (Oryctolagus cuniculus): a model for mammalian reproduction and early embryology.
2010,
Pubmed
Püschel,
Live rabbit embryo culture.
2010,
Pubmed
Quinlan,
Neuroectodermal fate of epiblast cells in the distal region of the mouse egg cylinder: implication for body plan organization during early embryogenesis.
1995,
Pubmed
Reis e Silva,
Alteration of DNA demethylation dynamics by in vitro culture conditions in rabbit pre-implantation embryos.
2012,
Pubmed
Rex,
Dynamic expression of chicken Sox2 and Sox3 genes in ectoderm induced to form neural tissue.
1997,
Pubmed
Rossant,
Developmental biology: A mouse is not a cow.
2011,
Pubmed
Ruffins,
Early migrating neural crest cells can form ventral neural tube derivatives when challenged by transplantation.
1998,
Pubmed
Samuel,
Ultrastructural studies of the rabbit placenta in the last third of gestation.
1975,
Pubmed
Sauka-Spengler,
A gene regulatory network orchestrates neural crest formation.
2008,
Pubmed
Schumacher,
A comparison of the teratogenic activity of thalidomide in rabbits and rats.
1968,
Pubmed
Serbedzija,
Vital dye analysis of cranial neural crest cell migration in the mouse embryo.
1992,
Pubmed
Shen,
Chicken transcription factor AP-2: cloning, expression and its role in outgrowth of facial prominences and limb buds.
1997,
Pubmed
,
Xenbase
Shi,
Methylation reprogramming and chromosomal aneuploidy in in vivo fertilized and cloned rabbit preimplantation embryos.
2004,
Pubmed
Simões-Costa,
Establishing neural crest identity: a gene regulatory recipe.
2015,
Pubmed
Steventon,
Differential requirements of BMP and Wnt signalling during gastrulation and neurulation define two steps in neural crest induction.
2009,
Pubmed
,
Xenbase
Stottmann,
Bone morphogenetic protein signaling is required in the dorsal neural folds before neurulation for the induction of spinal neural crest cells and dorsal neurons.
2011,
Pubmed
Stuhlmiller,
FGF/MAPK signaling is required in the gastrula epiblast for avian neural crest induction.
2012,
Pubmed
Stuhlmiller,
Current perspectives of the signaling pathways directing neural crest induction.
2012,
Pubmed
,
Xenbase
Suzuki,
Sox genes regulate type 2 collagen expression in avian neural crest cells.
2006,
Pubmed
Tam,
Regionalisation of the mouse embryonic ectoderm: allocation of prospective ectodermal tissues during gastrulation.
1989,
Pubmed
Tucker,
Expression of the HNK-1/NC-1 epitope in early vertebrate neurogenesis.
1988,
Pubmed
,
Xenbase
Tucker,
Identical reactivity of monoclonal antibodies HNK-1 and NC-1: conservation in vertebrates on cells derived from the neural primordium and on some leukocytes.
1984,
Pubmed
Umeda,
Long-term expandable SOX9+ chondrogenic ectomesenchymal cells from human pluripotent stem cells.
2015,
Pubmed
Viebahn,
Low proliferative and high migratory activity in the area of Brachyury expressing mesoderm progenitor cells in the gastrulating rabbit embryo.
2002,
Pubmed
Viebahn,
Signs of the principle body axes prior to primitive streak formation in the rabbit embryo.
1995,
Pubmed
Waddington,
The Development in vitro of Young Rabbit Embryos.
1933,
Pubmed
Wilson,
An early requirement for FGF signalling in the acquisition of neural cell fate in the chick embryo.
2000,
Pubmed
,
Xenbase
Wilson,
Neural crest cell lineage segregation in the mouse neural tube.
2004,
Pubmed
