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Development May 1, 2003; 130 (10): 2199-212.

A novel role for a nodal-related protein; Xnr3 regulates convergent extension movements via the FGF receptor.

Yokota C , Kofron M , Zuck M , Houston DW , Isaacs H , Asashima M , Wylie CC , Heasman J .

Convergent extension behaviour is critical for the formation of the vertebrate body axis. In Xenopus, components of the Wnt signaling pathway have been shown to be required for convergent extension movements but the relationship between cell fate and morphogenesis is little understood. We show by loss of function analysis that Xnr3 activates Xbra expression through FGFR1. We show that eFGF activity is not essential in the pathway, and that dishevelled acts downstream of Xnr3 and not in a parallel pathway. We provide evidence for the involvement of the EGF-CFC protein FRL1, and suggest that the pro-domain of Xnr3 may be required for its activity. Since Xnr3 is a direct target of the maternal betacatenin/XTcf3 signaling pathway, it provides the link between the initial, maternally controlled, allocation of cell fate, and the morphogenetic movements of cells derived from the organizer.

PubMed ID: 12668633
Article link: Development
Grant support: [+]

Species referenced: Xenopus
Genes referenced: chdh chrd.1 dvl1 dvl2 egf en2 fgf4 fgfr1 gsc myod1 ncam1 nodal nodal1 nodal3.1 nodal3.2 nrp1 odc1 ptpn11 tbxt tdgf1.3
Morpholinos: fgf4 MO1 nodal3.1 MO1

Article Images: [+] show captions