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Zool Res August 20, 2018;

Developmental expression of three prmt genes in Xenopus.

Wang CD , Guo XF , Wong TCB , Wang H , Qi XF , Cai DQ , Deng Y , Zhao H .

Protein arginine methyltransferases (PRMTs) are involved in many cellular processes via the arginine methylation of histone or non-histone proteins. We examined the expression patterns of prmt4, prmt7, and prmt9 during embryogenesis in Xenopus using whole-mount in situ hybridization and quantitative reverse transcription polymerase chain reaction (RT-PCR). Xenopus prmt4 and prmt7 were expressed in the neural crest, brain, and spinal cord, and also detected in the eye, branchial arches, and heart at the tailbud stage. Specific prmt9 signals were not detected in Xenopus embryos until the late tailbud stage when weak expression was observed in the branchial arches. Quantitative RT-PCR indicated that the expressions of prmt4 and prmt7 were up-regulated during the neurula stage, whereas prmt9 maintained its low expression until the late tailbud stage, consistent with the whole-mount in situ hybridization results. Thus, the developmental expression patterns of these three prmt genes in Xenopus embryos provide a basis for further functional study of such genes.

PubMed ID: 30127333
PMC ID: PMC6378560
Article link: Zool Res

Species referenced: Xenopus laevis
Genes referenced: carm1 prmt1 prmt2 prmt3 prmt5 prmt6 prmt7 prmt8 prmt9

Article Images: [+] show captions
References [+] :
Batut, The Ca2+-induced methyltransferase xPRMT1b controls neural fate in amphibian embryo. 2005, Pubmed, Xenbase