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PLoS One
2018 Nov 07;1311:e0205834. doi: 10.1371/journal.pone.0205834.
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Development of epithelial tissues: How are cleavage planes chosen?
Xin Y
,
Karunarathna Mudiyanselage CM
,
Just W
.
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The cross-section of a cell in a monolayer epithelial tissue can be modeled mathematically as a k-sided polygon. Empirically studied distributions of the proportions of k-sided cells in epithelia show remarkable similarities in a wide range of evolutionarily distant organisms. A variety of mathematical models have been proposed for explaining this phenomenon. The highly parsimonious simulation model of (Patel et al., PLoS Comput. Biol., 2009) that takes into account only the number of sides of a given cell and cell division already achieves a remarkably good fit with empirical distributions from Drosophila, Hydra, Xenopus, Cucumber, and Anagallis. Within the same modeling framework as in that paper, we introduce additional options for the choice of the endpoints of the cleavage plane that appear to be biologically more realistic. By taking the same data sets as our benchmarks, we found that combinations of some of our new options consistently gave better fits with each of these data sets than previously studied ones. Both our algorithm and simulation data are made available as research tools for future investigations.
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30403682
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Fig 1. The cleavage plane is determined by choosing side1 and side2.
Fig 2. An example of two consecutive cell divisions.
Fig 3. The meaning of the angle β.
Fig 4. Sample probability distributions of the choice of side2 for ‘Choice2’ options ‘Even-Binomial’, ‘rotNorm’ and ‘rotTanNorm’.Relevant parameters (for an 8-sided cell): ‘probB’ = 0.3 for ‘Even-Binomial’, ‘stdbeta’ = 0.15 for ‘rotNorm’, and ‘stdbeta’ = 0.15 for ‘rotTanNorm’.
Fig 5. Simulated and empirically verified polygonal distributions.Gray scale: real organisms. Reddish: new strategies. Blue: best-fitting option from [3].
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