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Gen Comp Endocrinol January 1, 2019; 271 91-96.

Involvement of epigenetic modifications in thyroid hormone-dependent formation of adult intestinal stem cells during amphibian metamorphosis.

Fu L , Yin J , Shi YB .

Amphibian metamorphosis has long been used as model to study postembryonic development in vertebrates, a period around birth in mammals when many organs/tissues mature into their adult forms and is characterized by peak levels of plasma thyroid hormone (T3). Of particular interest is the remodeling of the intestine during metamorphosis. In the highly-related anurans Xenopus laevis and Xenopus tropicalis, this remodeling process involves larval epithelial cell death and de novo formation of adult stem cells via dedifferentiation of some larval cells under the induction of T3, making it a valuable system to investigate how adult organ-specific stem cells are formed during vertebrate development. Here, we will review some studies by us and others on how T3 regulates the formation of the intestinal stem cells during metamorphosis. We will highlight the involvement of nucleosome removal and a positive feedback mechanism involving the histone methyltransferases in gene regulation by T3 receptor (TR) during this process.

PubMed ID: 30472386
PMC ID: PMC6322911
Article link: Gen Comp Endocrinol
Grant support: [+]
Genes referenced: bmp1 dot1l ep300 hdac3 lgr5 myc ncoa3 nodal prmt1

Article Images: [+] show captions
References [+] :
Amano, Isolation of genes involved in intestinal remodeling during anuran metamorphosis. 1999, Pubmed, Xenbase

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