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XB-ART-556
Dev Biol May 1, 2006; 293 (1): 252-67.

Tes regulates neural crest migration and axial elongation in Xenopus.

Dingwell KS , Smith JC .


Abstract
Tes is a member of an emerging family of proteins sharing a set of protein motifs referred to as PET-LIM domains. PET-LIM proteins such as Prickle regulate cell behavior during gastrulation in Xenopus and zebrafish, and to ask whether Tes is also involved in controlling cell behavior, we isolated its Xenopus orthologue. Xtes is expressed as a maternal transcript that is maintained at low levels until neurula stages when expression is elevated in the head and axial structures. Depletion of Xtes leads to a foreshortened head and severe defects in axis elongation. The anterior defect is due in part to the inhibition of cranial neural crest migration while the defects in elongation may be due to perturbation of expression of XFGF8, Xdelta-1 and Xcad-3 and thereby to disruption of posterior somitogenesis. Finally, we note that simultaneous depletion of Xtes and Xenopus Prickle results in axial defects that are more severe than those resulting from depletion of Xtes alone, suggesting that the two proteins act together to control axial elongation.

PubMed ID: 16554046
Article link: Dev Biol
Grant support: [+]
Genes referenced: cad cdx4 dll1 egr2 en2 fgf8 fn1 foxd3 foxg1 odc1 prickle1 rax snai2 sox3 spry2 tes twist1
GO keywords: neural crest cell migration [+]
Antibodies: Notochord Ab2 Somite Ab1
Morpholinos: prickle1 MO1 prickle1 MO2 tes MO1 tes MO2


Article Images: [+] show captions


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