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Sci Rep January 1, 2017; 7 (1): 8874.

Peroxiredoxin1, a novel regulator of pronephros development, influences retinoic acid and Wnt signaling by controlling ROS levels.

Chae S , Lee HK , Kim YK , Jung Sim H , Ji Y , Kim C , Ismail T , Park JW , Kwon OS , Kang BS , Lee DS , Bae JS , Kim SH , Min KJ , Kyu Kwon T , Park MJ , Han JK , Kwon T , Park TJ , Lee HS .

Peroxiredoxin1 (Prdx1) is an antioxidant enzyme belonging to the peroxiredoxin family of proteins. Prdx1 catalyzes the reduction of H2O2 and alkyl hydroperoxide and plays an important role in different biological processes. Prdx1 also participates in various age-related diseases and cancers. In this study, we investigated the role of Prdx1 in pronephros development during embryogenesis. Prdx1 knockdown markedly inhibited proximal tubule formation in the pronephros and significantly increased the cellular levels of reactive oxygen species (ROS), which impaired primary cilia formation. Additionally, treatment with ROS (H2O2) severely disrupted proximal tubule formation, whereas Prdx1 overexpression reversed the ROS-mediated inhibition in proximal tubule formation. Epistatic analysis revealed that Prdx1 has a crucial role in retinoic acid and Wnt signaling pathways during pronephrogenesis. In conclusion, Prdx1 facilitates proximal tubule formation during pronephrogenesis by regulating ROS levels.

PubMed ID: 28827763
Article link: Sci Rep

Genes referenced: akt1 dvl2 lhx1 mapk1 odc1 pax2 pax8 pdzk1ip1 prdx1 rab40b rgn
GO keywords: kidney development [+]
Antibodies: Kidney Ab1 Kidney Ab2
Morpholinos: prdx1 MO1

Article Images: [+] show captions
References [+] :
Agharazii, Inflammatory cytokines and reactive oxygen species as mediators of chronic kidney disease-related vascular calcification. 2016, Pubmed

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