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XB-ART-56295
Dev Cell 2009 Feb 01;162:165-6. doi: 10.1016/j.devcel.2009.01.017.
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SUMO weighs in on a photoreceptor finish.

LaBonne C .


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In the developing retina the nuclear hormone receptor Nr2e3 has dual roles, promoting expression of rod-specific genes and repressing expression of cone specific genes. In a recent issue of Neuron, Onishi et al. show that PIAS3-mediated SUMOylation of Nr2e3 plays an essential role in the specification of rod photoreceptors by converting Nr2e3 to a potent repressor of cone gene expression.

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Species referenced: Xenopus
Genes referenced: nr2e3 pias3