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Semin Cell Dev Biol July 1, 2009; 20 (5): 565-74.

Repatterning in amphibian limb regeneration: A model for study of genetic and epigenetic control of organ regeneration.

Yakushiji N , Yokoyama H , Tamura K .

Limb regeneration is an excellent model for understanding organ reconstruction along PD, AP and DV axes. Re-expression of genes involved in axial pattern formation is essential for complete limb regeneration. The cellular positional information in the limb blastema has been thought to be a key factor for appropriate gene re-expression. Recently, it has been suggested that epigenetic mechanisms have an essential role in development and regeneration processes. In this review, we discuss how epigenetic mechanisms may be involved in the maintenance of positional information and the regulation of gene re-expression during limb regeneration.

PubMed ID: 19146968
Article link: Semin Cell Dev Biol

Species referenced: Xenopus
Genes referenced: mecp2 shh sin3a
GO keywords: animal organ regeneration [+]

Article Images: [+] show captions