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XB-ART-56554
Biochem Biophys Res Commun January 1, 2020; 522 (4): 990-995.

The AP-1 transcription factor JunB functions in Xenopus tail regeneration by positively regulating cell proliferation.

Nakamura M , Yoshida H , Takahashi E , Wlizla M , Takebayashi-Suzuki K , Horb ME , Suzuki A .


Abstract
Xenopus tropicalis tadpoles can regenerate an amputated tail, including spinal cord, muscle and notochord, through cell proliferation and differentiation. However, the molecular mechanisms that regulate cell proliferation during tail regeneration are largely unknown. Here we show that JunB plays an important role in tail regeneration by regulating cell proliferation. The expression of junb is rapidly activated and sustained during tail regeneration. Knockout (KO) of junb causes a delay in tail regeneration and tissue differentiation. In junb KO tadpoles, cell proliferation is prevented before tissue differentiation. Furthermore, TGF-β signaling, which is activated just after tail amputation, regulates the induction and maintenance of junb expression. These findings demonstrate that JunB, a downstream component of TGF-β signaling, works as a positive regulator of cell proliferation during Xenopus tail regeneration.

PubMed ID: 31812242
PMC ID: PMC6989358
Article link: Biochem Biophys Res Commun
Grant support: [+]
Genes referenced: junb

References [+] :
Adams, H+ pump-dependent changes in membrane voltage are an early mechanism necessary and sufficient to induce Xenopus tail regeneration. 2007, Pubmed, Xenbase


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