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Adv Exp Med Biol January 1, 2019; 1185 401-405.

Autophagy Induction by HDAC Inhibitors Is Unlikely to be the Mechanism of Efficacy in Prevention of Retinal Degeneration Caused by P23H Rhodopsin.

Wen RH , Loewen AD , Vent-Schmidt RYJ , Moritz OL .

We previously found that valproic acid (VPA) and other histone deacetylase inhibitors (HDACis) ameliorate retinal degeneration (RD) caused by P23H rhodopsin in Xenopus laevis larvae and hypothesized that this may be due to enhancement of autophagy. Here we use X. laevis expressing an autophagy marker to assess effects of HDACis on autophagy. We also assess the effects of non-HDACi activators and inducers of autophagy on RD caused by P23H rhodopsin.

PubMed ID: 31884645
Article link: Adv Exp Med Biol

Genes referenced: hdac3 rho

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