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XB-ART-56621
J Cell Mol Med February 1, 2020; 24 (4): 2531-2541.

Cardiac telocytes exist in the adult Xenopus tropicalis heart.

Lv L , Liao Z , Luo J , Chen H , Guo H , Yang J , Huang R , Pu Q , Zhao H , Yuan Z , Feng S , Qi X , Cai D .


Abstract
Recent research has revealed that cardiac telocytes (CTs) play an important role in cardiac physiopathology and the regeneration of injured myocardium. Recently, we reported that the adult Xenopus tropicalis heart can regenerate perfectly in a nearly scar-free manner after injury via apical resection. However, whether telocytes exist in the X tropicalis heart and are affected in the regeneration of injured X tropicalis myocardium is still unknown. The present ultrastructural and immunofluorescent double staining results clearly showed that CTs exist in the X tropicalis myocardium. CTs in the X tropicalis myocardium were mainly twined around the surface of cardiomyocyte trabeculae and linked via nanocontacts between the ends of the telopodes, forming a three-dimensional network. CTs might play a role in the regeneration of injured myocardium.

PubMed ID: 31930692
PMC ID: PMC7028868
Article link: J Cell Mol Med
Grant support: [+]
Genes referenced: kit pecam1 vwf
GO keywords: regeneration

Disease Ontology terms: myocardial infarction

Article Images: [+] show captions
References [+] :
Anderson, The three-dimensional arrangement of the myocytes in the ventricular walls. 2009, Pubmed


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