Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-56730
Arthritis Rheum 1986 Mar 01;293:400-10. doi: 10.1002/art.1780290314.
Show Gene links Show Anatomy links

Characterization of the antibody response in mice with type II collagen-induced arthritis, using monoclonal anti-type II collagen antibodies.

Holmdahl R , Rubin K , Klareskog L , Larsson E , Wigzell H .


???displayArticle.abstract???
Twenty monoclonal antibodies reactive with type II collagen were characterized as to their determinant specificity and their reactivity with cartilage-derived components. The monoclonal antibodies reacted with 7 different epitopes on the native type II collagen triple helical structure. Antibodies defining 3 of these epitopes occurred more frequently in sera from arthritic mice than in sera from nonarthritic mice. In vivo injection of some selected autoreactive antibodies caused synovitis, but in no case did it give rise to full-blown arthritis.

???displayArticle.pubmedLink??? 2421741
???displayArticle.link??? Arthritis Rheum


???displayArticle.antibodies??? Col2a1 Ab2