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XB-ART-56992
Dokl Biochem Biophys 2019 Nov 01;4891:377-379. doi: 10.1134/S1607672919060061.
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Histone Tails Promote PARP1-Dependent Structural Rearrangements in Nucleosomes.

Maluchenko NV , Sultanov DS , Kotova EY , Kirpichnikov MP , Studitsky VM , Feofanov AV .


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PARP 1 alters the wrapping of nucleosomal DNA on the histone octamer, thereby modulating the accessibility of different genome sites to nuclear protein factors. Here, we show that non-structured histone tails are involved in the PARP1-induced structural rearrangements in nucleosomes, facilitate and stabilize them, but do not affect the enzymatic activity of PARP1.

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Species referenced: Xenopus laevis
Genes referenced: parp1

References [+] :
Clark, Alternative modes of binding of poly(ADP-ribose) polymerase 1 to free DNA and nucleosomes. 2012, Pubmed