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XB-ART-57104
Cells June 19, 2020; 9 (6):

Translational Control of Xenopus Oocyte Meiosis: Toward the Genomic Era.

Meneau F , Dupré A , Jessus C , Daldello EM .


Abstract
The study of oocytes has made enormous contributions to the understanding of the G2/M transition. The complementarity of investigations carried out on various model organisms has led to the identification of the M-phase promoting factor (MPF) and to unravel the basis of cell cycle regulation. Thanks to the power of biochemical approaches offered by frog oocytes, this model has allowed to identify the core signaling components involved in the regulation of M-phase. A central emerging layer of regulation of cell division regards protein translation. Oocytes are a unique model to tackle this question as they accumulate large quantities of dormant mRNAs to be used during meiosis resumption and progression, as well as the cell divisions during early embryogenesis. Since these events occur in the absence of transcription, they require cascades of successive unmasking, translation, and discarding of these mRNAs, implying a fine regulation of the timing of specific translation. In the last years, the Xenopus genome has been sequenced and annotated, enabling the development of omics techniques in this model and starting its transition into the genomic era. This review has critically described how the different phases of meiosis are orchestrated by changes in gene expression. The physiological states of the oocyte have been described together with the molecular mechanisms that control the critical transitions during meiosis progression, highlighting the connection between translation control and meiosis dynamics.

PubMed ID: 32575604
PMC ID: PMC7348711
Article link: Cells
Grant support: [+]
Genes referenced: akt1s1 arpp19 aurka btg4 ccdc6 ccnb1 cdc25c cdk1 clspn cnot6l cnot7 cnot8 cpeb1 cul1 dcp1a dcp2 gys1 hadha kif11 mos msi1 rif1 rps6 spats2 spdya wee1 ythdf2 zar2
GO keywords: mitotic cell cycle [+]


Article Images: [+] show captions
References [+] :
Almonacid, Active Fluctuations of the Nuclear Envelope Shape the Transcriptional Dynamics in Oocytes. 2020, Pubmed


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