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XB-ART-57395
Development September 21, 2020; 147 (18):

FaceBase 3: analytical tools and FAIR resources for craniofacial and dental research.

Samuels BD , Aho R , Brinkley JF , Bugacov A , Feingold E , Fisher S , Gonzalez-Reiche AS , Hacia JG , Hallgrimsson B , Hansen K , Harris MP , Ho TV , Holmes G , Hooper JE , Jabs EW , Jones KL , Kesselman C , Klein OD , Leslie EJ , Li H , Liao EC , Long H , Lu N , Maas RL , Marazita ML , Mohammed J , Prescott S , Schuler R , Selleri L , Spritz RA , Swigut T , van Bakel H , Visel A , Welsh I , Williams C , Williams TJ , Wysocka J , Yuan Y , Chai Y .


Abstract
The FaceBase Consortium was established by the National Institute of Dental and Craniofacial Research in 2009 as a ''big data'' resource for the craniofacial research community. Over the past decade, researchers have deposited hundreds of annotated and curated datasets on both normal and disordered craniofacial development in FaceBase, all freely available to the research community on the FaceBase Hub website. The Hub has developed numerous visualization and analysis tools designed to promote integration of multidisciplinary data while remaining dedicated to the FAIR principles of data management (findability, accessibility, interoperability and reusability) and providing a faceted search infrastructure for locating desired data efficiently. Summaries of the datasets generated by the FaceBase projects from 2014 to 2019 are provided here. FaceBase 3 now welcomes contributions of data on craniofacial and dental development in humans, model organisms and cell lines. Collectively, the FaceBase Consortium, along with other NIH-supported data resources, provide a continuously growing, dynamic and current resource for the scientific community while improving data reproducibility and fulfilling data sharing requirements.

PubMed ID: 32958507
PMC ID: PMC7522026
Article link: Development


Genes referenced: elavl2

References [+] :
Attanasio, Fine tuning of craniofacial morphology by distant-acting enhancers. 2013, Pubmed